Genome-wide association study of flowering time and grain yield traits in a worldwide collection of rice germplasm

A high-density haplotype map recently enabled a genome-wide association study (GWAS) in a population of indica subspecies of Chinese rice landraces. Here we extend this methodology to a larger and more diverse sample of 950 worldwide rice varieties, including the Oryza sativa indica and Oryza sativa japonica subspecies, to perform an additional GWAS. We identified a total of 32 new loci associated with flowering time and with ten grain-related traits, indicating that the larger sample increased the power to detect trait-associated variants using GWAS. To characterize various alleles and complex genetic variation, we developed an analytical framework for haplotype-based de novo assembly of the low-coverage sequencing data in rice. We identified candidate genes for 18 associated loci through detailed annotation. This study shows that the integrated approach of sequence-based GWAS and functional genome annotation has the potential to match complex traits to their causal polymorphisms in rice.     

CEP152 is a genome maintenance protein disrupted in Seckel syndrome

Functional impairment of DNA damage response pathways leads to increased genomic instability. Here we describe the centrosomal protein CEP152 as a new regulator of genomic integrity and cellular response to DNA damage. Using homozygosity mapping and exome sequencing, we identified CEP152 mutations in Seckel syndrome and showed that impaired CEP152 function leads to accumulation of genomic defects resulting from replicative stress through enhanced activation of ATM signaling and increased H2AX phosphorylation.     

3类3-正则图中的1-因子数

构造了3类3-正则图,并用划分与求和的方法给出了这3类图1-因子数的计算公式.     

Zircon isotopic ages from magnetite quartzites of the Jianping metamorphic complex, western Liaoning Province

Using the zircon Pb evaporation method and high precise ion microprobe analyses, zircon isotopic ages in supracrustal magnetite quartzites from Jianping metamorphic complex have been obtained. The results show that the deposition of the supracrustal rocks occurred around 2 552–2 520 Ma and the peak of granulite facies metamorphism reached at about 2 487 Ma; about (1 806±16) Ma, i.e. Mid-Proterozoic, the other possible metamorphic event with relatively low intensity happened in the study area. It is speculated that a likely tectonic setting where the Jianping metamorphic complex formed is an active continental margin that is involved in continental collision and crustal thickening shortly after its formation.     

Scan Strategy in Electron Beam Selective Melting

In electron beam selective melting process, powder pushed-away phenomena and uneven temperature field are two main obstacles, which are greatly associated with the electron beam scan mode. In this paper, various scan strategies, including iterative scan mode, reverse scan mode, interlaced reverse scan mode, randomized block scan mode, and constant length scan mode, are investigated. The analyses for each scan strategy are presented based on the influence to the temperature field over the formation zone and the powder pushed-away phenomena. The most promising strategy, interlaced reverse scan mode, is approved by the ANSYS simulation and a two-dimensional scan experiment. The result shows interlaced reverse scan mode can improve the uniformity of the temperature field and reduce the powder pushed-away phenomena.     

陈列语言中文字说明的意义及特点

随着陈列语言研究的理论化和科学化,其中对于文字说明部分的探索人们也有了越来越深入的认识.文章以山西博物院基本陈列<晋魂>为例,陈列语言中文字说明的意义及特点进行一些探讨.     

基于效益最大化的桥梁检修决策模型

运用贝叶斯分析方法,建立一种确定桥梁检修策略的动态模型,该模型包含了多阶段的"信息收集--数据分析--决策"过程,同时将先验信息和检查信息相结合,为决策提供更加充分的数据支持.算例考虑了两种检查方案和4种维修方案集,以检查净效益最大化为目的,在分析基准期内设计最佳的检查时间和检查方案,然后以维修综合成本最小为原则对可能出现的检查结果制定最佳维修方案.     

浅谈培训教育在调度班组建设中的意义

电网调度的主要任务是指挥电网的安全运行,所以,调度员的培训一直是调度工作中重要的一环。文章从具体的学、看、画等方面,阐述了调度培训的方法。