Cellular responses to mild heat stress

Since its discovery in 1962 by Ritossa, the heat shock response has been extensively studied by a number of investigators to understand the molecular mechanism underlying the cellular response to heat stress. The most well characterized heat shock response is induction of the heat shock proteins that function as molecular chaperones and exert cell cycle regulatory and anti-apoptotic activities. While most investigators have focused their studies on the toxic effects of heat stress in organisms such as severe heat stress-induced cell cycle arrest and apoptosis, the cellular response to fever-ranged mild heat stress has been rather underestimated. However, the cellular response to mild heat stress is likely to be more important in a physiological sense than that to severe heat stress because the body temperature of homeothermic animals increases by only 1–2°C during febrile diseases. Here we provide information that mild heat stress does have some beneficial role in organisms via positively regulating cell proliferation and differentiation, and immune response in mammalian cells.Received 14 May 2004; received after revision 2 August 2004; accepted 16 August 2004     

WAN路由器备份链路的设计与实现

阐述了广域网链路之一--DDR的工作原理,提出了一种设计思路并且加以实现,并说明了配置文件、拨号过程跟踪和链路速率检测的工作过程.该方法具有较好的实用性,在一些网络环境中能得到较好的应用.     

Compensatory caspase activation in MPP+-induced cell death in dopaminergic neurons

Many have hypothesized that cell death in Parkinsons disease is via apoptosis and, specifically, by the mitochondrial-mediated apoptotic pathway. We tested this hypothesis using a mouse dopaminergic cell line of mesencephalic origin, MN9D, challenged with the Parkinsonism-causing neurotoxin MPP⁺ (1-methyl-4-phenylpyridinium ion). Apoptosis was the main mode of cell death when the cells were subjected to MPP⁺ treatment under serum-free conditions for 24 h. Caspase-3 and caspase-9, however, were not activated, thus indicating the existence of alternate or compensatory cell death pathway(s) in dopaminergic neuronal cells. Using caspase inhibitors, we demonstrated that these pathways involve caspase-2, –8, –6 and –7. A time-course study indicated that activation of caspase-2 and –8 occurred upstream of caspase-6 and caspase-7. Upon MPP⁺ challenge, the apoptosis-inducing factor was translocated from the mitochondria into the MN9D cytosol and nucleus. These results suggest the existence of alternative apoptotic pathways in dopaminergic neurons.Received 20 September 2004; received after revision 5 November 2004; accepted 22 November 2004     

分子电子学

作为纳米电子学的一个重要分支,分子电子学在近年来得到了巨大的发展,并成为国际上研究的热点。本文介绍了各种分子器件的制作技术及基本工作原理,回顾了近年来分子电子学的最新进展,展望了分子电子学的未来发展。     

南宁大桥地锚内力性状分析

以南宁大桥的扣索地锚和缆索地锚为对象,研究扣索地锚和缆索地锚的内力性状.采用有限元计算软件ANSYS中的solid45和beam44对南宁大桥扣索地锚和缆索地锚的实际情况进行建模,分析和比较在不同工况条件下扣索地锚和缆索地锚的受力状况.结果表明:地锚分别采用实体单元与梁单元模型,其计算结果基本相同;承台顶部的配重对结构桩体的轴向力影响相对较大达到17%,但对弯矩的影响都很小,效应都小于1%;结构自身具有较好的抗拔性能.大桥吊装的顺利实施证明:采用合理的地锚结构比对结构施加配重更为经济合理.     

基于高校图书网的基层图书MIS建设

文章针对高等院校校园图书网覆盖存在的疏漏、基层资料室在专业信息利用方面作用的弱化,以及基层图书部门统计工作繁琐滞后的现象,尝试设计出适合基层图书资料管理的信息系统,以达到校园图书网资料数据建设的完整性并提高管理工作的效率.     

萘酚绿B在N80钢片表面的吸附行为初步分析

文章采用交流阻抗法研究了萘酚绿B处于一定浓度硫酸溶液中在N80钢表面的吸附行为.实验结果表明它在金属表面的吸附行为在实验采用的浓度范围内遵从郎格谬尔吸附等温式,N80钢对萘酚绿B分子的吸附主要是化学吸附.     

TiC掺杂对MCMB烧结体组织和性能的影响

以Tween 80为分散剂,分别以丙烯酰胺和N,N'-亚甲基双丙烯酰胺为单体和交联剂,采用凝胶注模工艺制备中间相碳微球(mesocarbon microbead,MCMB)片状素坯,再经过1 600 ℃的烧结,制备MCMB素坯烧结体试样.试验研究了粒度大小对粉体分散性、MCMB碳材料催化石墨化效果、烧结后MCMB碳材料层板物理性能的影响,并分析了产生这些影响的原因.研究结果表明:50 nm的TiC在MCMB烧结体中的分散效果好于15 μm的TiC;随着Ti质量分数的增加,掺杂50 nm 的TiC层板性能优于掺杂15 μm的层板;50 nm的TiC比15 μm的TiC更适合做MCMB的掺杂物.     

基于价值的实验室评估体系构建

现代化实验室的价值取向在于能更好地为教学、科研、生产服务。实验室在长期的教学、科研、生产活动中是否体现了其应有的价值,是衡量实验室建设、管理成败的关键。文中构建了一种基于价值的实验室评估体系模型,以对实验室的价值进行科学的评判。     

海洋科技发展演变的影响因素及规律探析

海洋科技在漫长的发展演变过程中,由于多种因素的交织作用而形成了特有的发展规律。基于分析影响海洋科技发展的诸如政治、经济、军事等各种因素,探讨海洋科技发展演变规律,有利于深层次理解海洋科技的发展历程、正确把握其发展脉络,并对未来的走势作出科学预测。