The genome of the mesopolyploid crop species Brassica rapa

We report the annotation and analysis of the draft genome sequence of Brassica rapa accession Chiifu-401-42, a Chinese cabbage. We modeled 41,174 protein coding genes in the B. rapa genome, which has undergone genome triplication. We used Arabidopsis thaliana as an outgroup for investigating the consequences of genome triplication, such as structural and functional evolution. The extent of gene loss (fractionation) among triplicated genome segments varies, with one of the three copies consistently retaining a disproportionately large fraction of the genes expected to have been present in its ancestor. Variation in the number of members of gene families present in the genome may contribute to the remarkable morphological plasticity of Brassica species. The B. rapa genome sequence provides an important resource for studying the evolution of polyploid genomes and underpins the genetic improvement of Brassica oil and vegetable crops.     

Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1

Hypovolemic shock (dengue shock syndrome (DSS)) is the most common life-threatening complication of dengue. We conducted a genome-wide association study of 2,008 pediatric cases treated for DSS and 2,018 controls from Vietnam. Replication of the most significantly associated markers was carried out in an independent Vietnamese sample of 1,737 cases and 2,934 controls. SNPs at two loci showed genome-wide significant association with DSS. We identified a susceptibility locus at MICB (major histocompatibility complex (MHC) class I polypeptide-related sequence B), which was within the broad MHC region on chromosome 6 but outside the class I and class II HLA loci (rs3132468, P(meta) = 4.41 × 10(-11), per-allele odds ratio (OR) = 1.34 (95% confidence interval: 1.23-1.46)). We identified associated variants within PLCE1 (phospholipase C, epsilon 1) on chromosome 10 (rs3765524, P(meta) = 3.08 × 10(-10), per-allele OR = 0.80 (95% confidence interval: 0.75-0.86)). We identify two loci associated with susceptibility to DSS in people with dengue, suggesting possible mechanisms for this severe complication of dengue.     

Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease

Kawasaki disease is a systemic vasculitis of unknown etiology, with clinical observations suggesting a substantial genetic contribution to disease susceptibility. We conducted a genome-wide association study and replication analysis in 2,173 individuals with Kawasaki disease and 9,383 controls from five independent sample collections. Two loci exceeded the formal threshold for genome-wide significance. The first locus is a functional polymorphism in the IgG receptor gene FCGR2A (encoding an H131R substitution) (rs1801274; P = 7.35 × 10(-11), odds ratio (OR) = 1.32), with the A allele (coding for histadine) conferring elevated disease risk. The second locus is at 19q13, (P = 2.51 × 10(-9), OR = 1.42 for the rs2233152 SNP near MIA and RAB4B; P = 1.68 × 10(-12), OR = 1.52 for rs28493229 in ITPKC), which confirms previous findings(1). The involvement of the FCGR2A locus may have implications for understanding immune activation in Kawasaki disease pathogenesis and the mechanism of response to intravenous immunoglobulin, the only proven therapy for this disease.     

第19届亚青赛中我国青年男子篮球技战术特点研究

通过对第19届亚青赛各场比赛进行现场观察、统计,对中国国青队技战术特点进行全面的研究和分析,并对比强队找出差距,给予客观、综合的评价,以期对我国篮球的发展提供科学、有益的参考．     

PVFS数据访问的负载平衡

分析了并行文件系统PVFS中存在负载不均衡的情况,提出了根据负载情况迁移数据或做热点的副本的负载平衡方法．描述了迁移过程中考虑到迁移代价,选取最优迁移方式．提出由执行I／O的10D节点统计负载情况并传输到元数据管理节点MGR,MGR节点实现迁移和制作副本,还要维护副本的一致性的策略．     

能耗均衡的低功耗自适应集分区路由改进算法

针对LEACH算法簇头选取不佳、网络寿命过短问题,提出一种基于分区的LEACH改进算法。该算法根据节点剩余能量、邻居节点数及距基站距离对簇头选举产生的影响,对簇头选举函数进行优化;对监测区域进行分区,不同分区采取不同的数据传输方式,减少基站附近簇头节点转发信息的负载量,有效避免基站附近“能量空洞”现象的发生。实验结果表明,相比于LEACH和LEACH-EDP算法,本文改进算法第一死亡节点出现轮次分别推迟了23.32%、18.44%,网络寿命分别延长了32.27%、21.49%。     

一种新型双磨盘式磨粉机的研究

应用剪切式粉碎原理所研究的新型双磨盘式磨粉机具有独特的两组动、静盘式机构及间隙调整机构,并配备了相应的磨粉工艺系统。结构设计紧凑,生产效率高,维护保养简单。在热敏性粉体加工、非铁(污染)材料粉体和粘性物体磨粉等行业应用广泛。     

Collaborative City Digital Twin for the COVID-19 Pandemic:A Federated Learning Solution

The novel coronavirus,COVID-19,has caused a crisis that affects all segments of the population.As the knowledge and understanding of COVID-19 evolve,an appropri...     

通用海量数据库性能测试系统的设计与实现

为客观反映数据库实际运行性能,设计一种可配置数据库性能测试标准,它能够针对具体应用数据库系统,建立相应的控制模型、数据模型和事务处理模型。控制模型描述数据库的运行模式,数据模型描述用户访问数据库的数据集合,事务处理模型描述用户访问数据库的行为模式。控制模型通过事务处理模型和数据模型组装动态SQL(standardquery language)语句,然后产生多个并发进程模拟大量实际用户访问数据库,以测试数据库的运行状况和性能。分析与实际测试结果表明,该系统能够根据实际应用系统配置数据库性能测试标准,较之目前国际上通用的固定模型测试标准如TPC-C等,更能够客观反映数据库实际运行性能。