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71.
H. -R. Olpe H. P. von Hahn C. G. Honegger 《Cellular and molecular life sciences : CMLS》1973,29(6):665-666
Zusammenfassung Die «non-histone»-Proteine (NHP) aus Hirn- und Leberzellkernen der Ratte wurden bei 5, 10 und 20 Tage alten und adulten Tieren extrahiert und das NHP/DNA-Verhältnis bestimmt. Die NHP aus den Gehirnzellkernen wurden disk-elektrophoretisch aufgetrennt. Leber- und Gehirnkerne zeigten eine geringe Zunahme des NHP/DNA-Quotienten während der ersten 20 postnatalen Tage. Es konnten jedoch für diese Altersstadien keine Veränderungen im Proteinmuster des Hirns gefunden werden.
This investigation was supported by grant No 89 of the Fritz Hoffmann-La Roche Foundation. 相似文献
This investigation was supported by grant No 89 of the Fritz Hoffmann-La Roche Foundation. 相似文献
72.
H. -R. Olpe H. P. von Hahn C. G. Honegger 《Cellular and molecular life sciences : CMLS》1972,28(10):781-783
Zusammenfassung Die Kerne des Rattenneocortex wurden mit einer nachBurdman modifizierten Methode auf einem diskontinuierlichen Saccharosegradienten in zwei Populationen aufgetrennt. Die Kerne werden durch das Protein/DNA-Verhältnis charakterisiert: kleine Kerne 1.5; grosse Kerne 3.9. Die morphologische Differenzierung im Phasenkontrastmikroskop erwies sich als ungenügend.
This investigation was supported by grant No. 89 of the Fritz Hoffmann-La Roche Foundation. 相似文献
This investigation was supported by grant No. 89 of the Fritz Hoffmann-La Roche Foundation. 相似文献
73.
Zusammenfassung Es wird gezeigt, dass in der Leber die Aktivität der PEP-Kinase und der Glycerolkinase nachgeburtlich ansteigt. Im braunen Fettgewebe fällt die PEP-Kinaseaktivität nach dem 40. Tag ab. Sie fehlt im weissen Fettgewebe. Die Pyruvatkinaseaktivität fällt in der Leber nach der Geburt ab, während sie im braunen Fettgewebe ansteigt. 相似文献
74.
P. Hahn 《Cellular and molecular life sciences : CMLS》1965,21(11):634-635
Zusammenfassung Die Aktivität hormonsensitiver Lipasen im weissen und braunen Fettgewebe der Ratte steigt zwischen dem 10. und 18. Tag nach der Geburt. Corticosteronzufuhr verursacht bei 10tägigen Ratten einen Aktivitätsanstieg. Adrenalin und Noradrenalin haben im braunen Fettgewebe keinen Effekt. 相似文献
75.
The postnatal development of hormone sensitive lipase in brown and white adipose tissue of the rat 总被引:1,自引:0,他引:1
P Hahn 《Experientia》1965,21(11):634-635
76.
H. Flohr R. Felix N. Hahn J. P. Pichotka 《Cellular and molecular life sciences : CMLS》1970,26(11):1224-1226
Zusammenfassung Es wird ein Verfahren zur autoradiographischen Darstellung der intramyocardialen Durchblutungsverteilung nach experimenteller Coronarocclusion angegeben. Im Versorgungsbereich akut verschlossener Coronararterien wird eine inhomogene Reduktion der Durchblutung beobachtet, wobei die Innenschichten regelmässig stärker als die subepicardialen Myocardanteile betroffen sind. 相似文献
77.
Jürgen Schnekenburger Ina-Alexandra Weber Daniela Hahn Igor Buchwalow Burkhard Krüger Elke Albrecht Wolfram Domschke Markus M. Lerch 《Cellular and molecular life sciences : CMLS》2009,66(15):2525-2537
The regulated secretion of pancreatic zymogens depends on a functional cytoskeleton and intracellular vesicle transport. To
study the dynamics of tubulin and its motor proteins dynein and kinesin during secretion in pancreatic acinar cells, we infused
rats with 0.1 μg/kg/h caerulein. Electron and fluorescence microscopy detected neither dynein nor kinesin at the apical secretory
pole, nor on the surface of mature zymogen granules. After 30 min of secretagogue stimulation, kinesin and the Golgi marker
protein 58 K were reallocated towards the apical plasma membrane and association of kinesin with tubulin was enhanced. Disruption
of acinar cell microtubules had no effect on initial caerulein-induced amylase release but completely blocked secretion during
a second stimulus. Our results suggest that mature zymogen granule exocytosis is independent of intact microtubules, kinesin
and dynein. However, microtubule-dependent mechanisms seem to be important for the replenishment of secretory vesicles by
redistribution of Golgi elements towards the apical cell pole.
J. Schnekenburger and I.-A. Weber have contributed equally to this work. 相似文献
78.
Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9 总被引:1,自引:0,他引:1
Krivtsov AV Twomey D Feng Z Stubbs MC Wang Y Faber J Levine JE Wang J Hahn WC Gilliland DG Golub TR Armstrong SA 《Nature》2006,442(7104):818-822
Leukaemias and other cancers possess a rare population of cells capable of the limitless self-renewal necessary for cancer initiation and maintenance. Eradication of these cancer stem cells is probably a critical part of any successful anti-cancer therapy, and may explain why conventional cancer therapies are often effective in reducing tumour burden, but are only rarely curative. Given that both normal and cancer stem cells are capable of self-renewal, the extent to which cancer stem cells resemble normal tissue stem cells is a critical issue if targeted therapies are to be developed. However, it remains unclear whether cancer stem cells must be phenotypically similar to normal tissue stem cells or whether they can retain the identity of committed progenitors. Here we show that leukaemia stem cells (LSC) can maintain the global identity of the progenitor from which they arose while activating a limited stem-cell- or self-renewal-associated programme. We isolated LSC from leukaemias initiated in committed granulocyte macrophage progenitors through introduction of the MLL-AF9 fusion protein encoded by the t(9;11)(p22;q23). The LSC were capable of transferring leukaemia to secondary recipient mice when only four cells were transferred, and possessed an immunophenotype and global gene expression profile very similar to that of normal granulocyte macrophage progenitors. However, a subset of genes highly expressed in normal haematopoietic stem cells was re-activated in LSC. LSC can thus be generated from committed progenitors without widespread reprogramming of gene expression, and a leukaemia self-renewal-associated signature is activated in the process. Our findings define progression from normal progenitor to cancer stem cell, and suggest that targeting a self-renewal programme expressed in an abnormal context may be possible. 相似文献
79.
80.
The Pendulum Swings Again: A Mathematical Reassessment of Galileo's Experiments with Inclined Planes
Alexander J. Hahn 《Archive for History of Exact Sciences》2002,56(4):339-361
After over 300 years of scrutiny, the subject of Galileo continues to be pursued with unabating intensity. Dava Sobel's Galileo's Daughter points to the popular interest in the man and his legacy. The Catholic Church, understandably interested in dispelling the notion that its censure of Galileo centuries ago is proof positive that religious faith and science as well as ecclesiastical authority and free pursuit of scholarship are irreconcilable, continues to offer explanations. New books, articles and conferences probe both in breadth and in depth the magnetic field charged by Galileo, science, and the Church. Galileo's analysis of the physics of motion has also received considerable attention. In particular, a great deal has been written during the past thirty years about the structure and objectives of three experiments with inclined planes. Galileo had carried them out in Padua and recorded them in his working papers. The assessments of the three experiments differ widely in points of detail, but all regard them as sophisticated, ingenious, and remarkable. This article presents a new critical study of these experiments. Its conclusion is that one of the experiments is indeed a success, but that the other two fail and are abandoned because Galileo did not have a firm enough grip on the underlying physical principles and mathematical relationships. 相似文献