Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease.

Transforming growth factor-beta 1 (TGF-beta 1) is a multifunctional growth factor that has profound regulatory effects on many developmental and physiological processes. Disruption of the TGF-beta 1 gene by homologous recombination in murine embryonic stem cells enables mice to be generated that carry the disrupted allele. Animals homozygous for the mutated TGF-beta 1 allele show no gross developmental abnormalities, but about 20 days after birth they succumb to a wasting syndrome accompanied by a multifocal, mixed inflammatory cell response and tissue necrosis, leading to organ failure and death. TGF-beta 1-deficient mice may be valuable models for human immune and inflammatory disorders, including autoimmune diseases, transplant rejection and graft versus host reactions.     

A New Local Search Algorithm for the Job Shop Scheduling Problem

0　IntroductionThejobshopschedulingproblemwithwhichwearecon cernedconsistsinschedulingasetofjobsonasetofma chinesfortheobjectiveofminimizingthemake span ,i.e .themaximumoftimeneededforfinishingalljobs,whichissubjecttotheconstrainsthateachjobhasafixedprocessingorderthroughthemachinesandeachmachinecanprocessatmostonejobatatime .ThisproblemisNP hardandevenisoneofthehardestcom binationaloptimizationproblems.Itiswellknownthatonlysmallsizeprobleminstancescanbesolvedwithinareasonablecomputa tionalti…     

二阶系统性能参数的研究

系统地总结了二阶系统动力学方程、传递函数、状态方程、时间响应及各种性能指标，并对其进行了详细的讨论，同时揭示了各种方法之间的内在联系及应用中注意的问题。     

Java字节代码程序的部分计值

为了有效地构造一个Java部分计值器，并且形式化地描述计值规则，提出了Java字节代码程序的静态语义，在此基础上构造了一个online的Java部分计值器，为今后能够建立一个完善而且实用的计值器提供了基础。     

模式语义链元建模及其应用

大粒度的模型转换是模型驱动软件开发场景下的重要技术需求，仅通过定义通用模型转换语言不足以满足这一需求，其中一个原因是通用模型转换语言工作在特定建模语言的元模型层次而非一般设计意图层次上．文中提出一种模式语义链(PSL)元建模方法．通过重型扩展统一建模语言(UML)元模型以直接形式化描述可表达一般设计意图的模式，并应用UML动作语义和元模型继承实现模式自动生成及转换．该方法为实现一船设计意图层次上的大粒度模型转换提供了有效支持．     

结合环的一个结构定理

本文讨论了一般结合环与(左)S-单式周期环在一定条件下的结构问题,得出它们分别是局部交换环与诣零交换环,或为局部交换环的亚直和。同时,推广和改进了文献[l]的结果。     

基于C/S与B/S相结合的教学管理系统的规划

针对当前高等教育体制改革学校办学规模不断扩大,存在多校区的办学模式,原来基于C/S或B/S单一模式结构的教学管理系统存在诸多弊端,对目前高校教学管理的实际需要和特点进行了分析,比较了两种模式的优缺点,提出了一种基于C/s和B/S结合的结构模式的教学管理系统,给出了基于该模式下教学管理系统的功能模块、实现方法、系统的软硬件支撑条件.     

盲孔法测量复合材料残余应力释放应变矩阵的有限元分析

对盲孔法测量正交各向异性复合材料残余应力释放应变矩阵进行有限元分析.以碳/环氧正交各向异性材料板为基础,对于不同孔深的盲孔进行有限元计算,得出与其相对应的释放应变矩阵,并分析孔深对释放应变矩阵的影响.为实际工程中残余应力的测试奠定了基础.     

Intramammary expression and therapeutic effect of a human lysozyme-expressing vector for treating bovine mastitis

To develop a gene therapy strategy for treating bovine mastitis, a new mammary-specific vector containing human lysozyme (hLYZ) cDNA and kanamycin resistance gene was constructed for intramammary expression and clinical studies. After one time acupuncture or intracisternal infusion of healthy cows with 400 μg of the p215C3LYZ vector, over 2.0 μg/ml of rhLYZ could be detected by enzymatic assay for about 3 weeks in the milk samples. Western blotting showed that rhLYZ secreted into milk samples from the vector-injected cows had molecular weight similar to that of the natural hLYZ in human colostrums. Twenty days after the primary injection, the quarters were re-injected with the same vector by quarter acupuncture and even higher concentrations of rhLYZ could be detected. Indirect competitive ELISA of milk samples showed that the vector injection did not induce detectable humoral immune response against hLYZ. Clinical studies showed that twice acupuncture of quarters with the p215C3LYZ vector had overt therapeutic effect on clinical and subclinical mastitis previously treated with antibiotics, including disappearance of clinical symptoms and relatively high microbiological cure rates. These data provide a solid rationale for using the vector to develop gene therapy for treating bovine mastitis.     

散热器型芯烘烤窑净化系统中分离器的设计研究

为解决铸铁散热器生产环境污染、产品成品率及产品质量低下等问题,笔者研制了XWJ-1型消烟雾化净化系统。该系统是根据乡镇企业实际状况,在原烘烤窑内采用烟道重新配置、油烟预处理、水雾化冷却、分离污染物、净化排放五步骤设计。通过6年多的试验运行和改进,结果证明,使用XWJ-1型油烟雾化净化系统,可以把高温、高浓度烟气中的焦油和有害气体减少90%,并分离净化到符合国家环保排放标准要求(GB9078-1996,GB16297-1996),较好地解决了热能利用、污染物回收利用等问题,提高了制芯及散热器的成品率及其质量,使企业经济效益显著提高。