Differentiation antigens in keratinocytes]

By means of indirect immunofluorescence with human sera it has been demonstrated that cytoplasmic components of the basal cell layer showed antigenic differences as compared to the upper cell layers. Moreover there were differences whether the cells were involved in a mucous, a parakeratinized or an orthokeratinized differentiation.     

T4 gene 32 protein model for control of activity at replication fork.

Limited hydrolysis of gene 32 protein by various proteinases results in the production of three stable cleavage products. Two of these products show an affinity for native T4 DNA cellulose that the uncleaved protein does not exhibit. A model for proteolytic cleavage and for the total unwinding of DNA in advance of the replication fork is discussed in terms of this unusual binding affinity.     

Effect of lesions of the locus coeruleus complex on the circadian rhythm of plasma corticosterone in the mouse

Summary An apparently transient elevation of basal morning (08.00 h) plasma corticosterone levels in male mice was found 48 h after bilateral electrolytic lesions of the brainstem locus coeruleus complex but was not observed 6 weeks after lesioning.Supported by Alfred P. Sloan Foundation research fellowships awarded to W.G. Luttge and S.F. Zornetzer.     

Mitotic activity of mast cells in precancerous mouse skin

Résumé En utilisant le 7, 12-diméthylbenza()nthracène (DMBA) on a provoqué un papillome dans la peau de la souris. On observe de nombreuses figures mitotiques dans les mastocytes du papillome formé. Le coefficient mitotique est de 0,6–0,7%; l'injection de colchicine augmente sa valeur.