全文获取类型
收费全文 | 40608篇 |
免费 | 102篇 |
国内免费 | 214篇 |
专业分类
系统科学 | 182篇 |
丛书文集 | 647篇 |
教育与普及 | 100篇 |
理论与方法论 | 146篇 |
现状及发展 | 19160篇 |
研究方法 | 1536篇 |
综合类 | 18620篇 |
自然研究 | 533篇 |
出版年
2013年 | 330篇 |
2012年 | 514篇 |
2011年 | 1024篇 |
2008年 | 671篇 |
2007年 | 735篇 |
2006年 | 719篇 |
2005年 | 706篇 |
2004年 | 753篇 |
2003年 | 687篇 |
2002年 | 681篇 |
2001年 | 1183篇 |
2000年 | 1122篇 |
1999年 | 780篇 |
1994年 | 385篇 |
1992年 | 742篇 |
1991年 | 551篇 |
1990年 | 646篇 |
1989年 | 622篇 |
1988年 | 608篇 |
1987年 | 700篇 |
1986年 | 651篇 |
1985年 | 816篇 |
1984年 | 632篇 |
1983年 | 552篇 |
1982年 | 483篇 |
1981年 | 508篇 |
1980年 | 634篇 |
1979年 | 1247篇 |
1978年 | 1070篇 |
1977年 | 1021篇 |
1976年 | 842篇 |
1975年 | 914篇 |
1974年 | 1184篇 |
1973年 | 1067篇 |
1972年 | 1103篇 |
1971年 | 1271篇 |
1970年 | 1541篇 |
1969年 | 1233篇 |
1968年 | 1214篇 |
1967年 | 1156篇 |
1966年 | 1014篇 |
1965年 | 706篇 |
1964年 | 263篇 |
1959年 | 388篇 |
1958年 | 697篇 |
1957年 | 507篇 |
1956年 | 439篇 |
1955年 | 411篇 |
1954年 | 404篇 |
1948年 | 308篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
981.
Ponderosa pine cones from 10 areas in Arizona were collected prior to natural seed dispersal and dissected to determine the number of sound, hollow, and insect-damaged seeds in each cone. Total and sound seed yields per cone did not vary significantly among areas but did vary significantly among trees within each area. Numbers of hollow and Megastigmus -infested (Hymenoptera: Torymidae) seeds varied significantly among areas and trees within areas. Numbers of sound seed increased significantly with increasing cone length but did not change with increasing numbers of cones per cluster. The percentages of Megastigmus -infested seed did not change significantly with increasing cone length or number of cones per cluster. 相似文献
982.
Dorald M. Allred 《西北部美国博物学家》2011,40(2)
A bite by Chiracanthium mildei L. Koch is described. 相似文献
983.
CFTR biogenesis starts with its co-translational insertion into the membrane of endoplasmic reticulum and folding of the cytosolic domains, towards the acquisition of a fully folded compact native structure. Efficiency of this process is assessed by the ER quality control system that allows the exit of folded proteins but targets unfolded/misfolded CFTR to degradation. If allowed to leave the ER, CFTR is modified at the Golgi and reaches the post-Golgi compartments to be delivered to the plasma membrane where it functions as a cAMP- and phosphorylation-regulated chloride/bicarbonate channel. CFTR residence at the membrane is a balance of membrane delivery, endocytosis, and recycling. Several adaptors, motor, and scaffold proteins contribute to the regulation of CFTR stability and are involved in continuously assessing its structure through peripheral quality control systems. Regulation of CFTR biogenesis and traffic (and its dysregulation by mutations, such as the most common F508del) determine its overall activity and thus contribute to the fine modulation of chloride secretion and hydration of epithelial surfaces. This review covers old and recent knowledge on CFTR folding and trafficking from its synthesis to the regulation of its stability at the plasma membrane and highlights how several of these steps can be modulated to promote the rescue of mutant CFTR. 相似文献
984.
985.
Horses damp the spring in their step. 总被引:6,自引:0,他引:6
The muscular work of galloping in horses is halved by storing and returning elastic strain energy in spring-like muscle-tendon units.These make the legs act like a child's pogo stick that is tuned to stretch and recoil at 2.5 strides per second. This mechanism is optimized by unique musculoskeletal adaptations: the digital flexor muscles have extremely short fibres and significant passive properties, whereas the tendons are very long and span several joints. Length change occurs by a stretching of the spring-like digital flexor tendons rather than through energetically expensive length changes in the muscle. Despite being apparently redundant for such a mechanism, the muscle fibres in the digital flexors are well developed. Here we show that the mechanical arrangement of the elastic leg permits it to vibrate at a higher frequency of 30-40 Hz that could cause fatigue damage to tendon and bone. Furthermore, we show that the digital flexor muscles have minimal ability to contribute to or regulate significantly the 2.5-Hz cycle of movement, but are ideally arranged to damp these high-frequency oscillations in the limb. 相似文献
986.
987.
Axial volcano, which is located near the intersection of the Juan de Fuca ridge and the Cobb-Eickelberg seamount chain beneath the northeast Pacific Ocean, is a locus of volcanic activity thought to be associated with the Cobb hotspot. The volcano rises 700 metres above the ridge, has substantial rift zones extending about 50 kilometres to the north and south, and has erupted as recently as 1998 (ref. 2). Here we present seismological data that constrain the three-dimensional velocity structure beneath the volcano. We image a large low-velocity zone in the crust, consisting of a shallow magma chamber and a more diffuse reservoir in the lower crust, and estimate the total magma volume in the system to be between 5 and 21 km3. This volume is two orders of magnitude larger than the amount of melt emplaced during the most recent eruption (0.1-0.2 km3). We therefore infer that such volcanic events remove only a small portion of the reservoir that they tap, which must accordingly be long-lived compared to the eruption cycle. On the basis of magma flux estimates, we estimate the crustal residence time of melt in the volcanic system to be a few hundred to a few thousand years. 相似文献
988.
Ion transport proteins must remove an ion's hydration shell to coordinate the ion selectively on the basis of its size and charge. To discover how the K+ channel solves this fundamental aspect of ion conduction, we solved the structure of the KcsA K+ channel in complex with a monoclonal Fab antibody fragment at 2.0 A resolution. Here we show how the K+ channel displaces water molecules around an ion at its extracellular entryway, and how it holds a K+ ion in a square antiprism of water molecules in a cavity near its intracellular entryway. Carbonyl oxygen atoms within the selectivity filter form a very similar square antiprism around each K+ binding site, as if to mimic the waters of hydration. The selectivity filter changes its ion coordination structure in low K+ solutions. This structural change is crucial to the operation of the selectivity filter in the cellular context, where the K+ ion concentration near the selectivity filter varies in response to channel gating. 相似文献
989.
In 1793 Lord Macartney arrived in China as ambassador of King George III. The aims of his embassy were largely directed towards the enlargement of British trade with the far east, and especially with China. The embassy also had a diplomatic and cultural mission, to impress the Chinese with British achievements. They were to do so largely by distributing presents of British manufactures, chief among them being scientific instruments. The Chinese refused the embassy's requests, and clearly regarded the gifts of instruments as merely ingenious toys. This paper describes the role of instruments in the embassy, and contrasts British expectations with Chinese attitudes to scientific instruments. The embassy's failure is shown to reveal fundamental differences in British and Chinese eighteenth-century responses to science, and has wide cultural implications. 相似文献
990.
Vegetation characteristics of 15 sagebrush community types identified on the Humboldt National Forest, northeastern Nevada, are described. A total of 218 plant species were found over the 372 relatively undisturbed rangeland communities sampled. The dominant plant families encountered were the Asteraceae (45 taxa), Poaceae (32 taxa), Scrophulariaceae (14 taxa), and the Fabaceae (12 taxa). Average annual dry weight production of the community types ranged from about 400 kg/ha/yr on types with Artemisia nova as the dominant sagebrush species to 1,200 kg/ha/yr on some A. tridentata ssp. vaseyana community types. A general increase in species richness and vegetation plus litter ground cover was observed within community types as the dominant sagebrush species changed from A. nova to A. arbuscula to A. longiloba to A. tridentata spp. tridentata to A. tridentata ssp. vaseyana . Major differences in plant species production and constancy exist between the sagebrush community types studied. 相似文献