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11.
Salmon Hillbertz NH Isaksson M Karlsson EK Hellmén E Pielberg GR Savolainen P Wade CM von Euler H Gustafson U Hedhammar A Nilsson M Lindblad-Toh K Andersson L Andersson G 《Nature genetics》2007,39(11):1318-1320
The dorsal hair ridge in Rhodesian and Thai Ridgeback dogs is caused by a dominant mutation that also predisposes to the congenital developmental disorder dermoid sinus. Here we show that the causative mutation is a 133-kb duplication involving three fibroblast growth factor (FGF) genes. FGFs play a crucial role in development, suggesting that the ridge and dermoid sinus are caused by dysregulation of one or more of the three FGF genes during development. 相似文献
12.
A. Bergenholtz G. T. Gustafson L. Hänström 《Cellular and molecular life sciences : CMLS》1977,33(2):254-256
Summary The effect of antifibrinolytic agents (antiplasminogen activators) on wound healing was studied in vitro. All these substances caused the proliferating epithelium to change direction and migrate to stratum corneum, resulting in a everted epiboly formation. 相似文献
13.
Mesodinium rubrum (Lohmann 1908) Jankowski 1976 (= Myrionecta rubra) is a common photosynthetic marine planktonic ciliate which can form coastal red-tides. It may represent a 'species complex' and since Darwin's voyage on the Beagle, it has been of great cytological, physiological and evolutionary interest. It is considered to be functionally a phytoplankter because it was thought to have lost the capacity to feed and possesses a highly modified algal endosymbiont. Whether M. rubrum is the result of a permanent endosymbiosis or a transient association between a ciliate and an alga is controversial. We conducted 'feeding' experiments to determine how exposure to a cryptophyte alga affects M. rubrum. Here we show that although M. rubrum lacks a cytostome (oral cavity), it ingests cryptophytes and steals their organelles, and may not maintain a permanent endosymbiont. M. rubrum does not fall into recognized cellular or functional categories, but may be a chimaera partially supported by organelle robbery. 相似文献
14.
Kidd JM Cooper GM Donahue WF Hayden HS Sampas N Graves T Hansen N Teague B Alkan C Antonacci F Haugen E Zerr T Yamada NA Tsang P Newman TL Tüzün E Cheng Z Ebling HM Tusneem N David R Gillett W Phelps KA Weaver M Saranga D Brand A Tao W Gustafson E McKernan K Chen L Malig M Smith JD Korn JM McCarroll SA Altshuler DA Peiffer DA Dorschner M Stamatoyannopoulos J Schwartz D Nickerson DA Mullikin JC Wilson RK Bruhn L Olson MV Kaul R Smith DR Eichler EE 《Nature》2008,453(7191):56-64
Genetic variation among individual humans occurs on many different scales, ranging from gross alterations in the human karyotype to single nucleotide changes. Here we explore variation on an intermediate scale--particularly insertions, deletions and inversions affecting from a few thousand to a few million base pairs. We employed a clone-based method to interrogate this intermediate structural variation in eight individuals of diverse geographic ancestry. Our analysis provides a comprehensive overview of the normal pattern of structural variation present in these genomes, refining the location of 1,695 structural variants. We find that 50% were seen in more than one individual and that nearly half lay outside regions of the genome previously described as structurally variant. We discover 525 new insertion sequences that are not present in the human reference genome and show that many of these are variable in copy number between individuals. Complete sequencing of 261 structural variants reveals considerable locus complexity and provides insights into the different mutational processes that have shaped the human genome. These data provide the first high-resolution sequence map of human structural variation--a standard for genotyping platforms and a prelude to future individual genome sequencing projects. 相似文献