相控阵天线板有限元动力学仿真分析

文章首先介绍了天线板滑倒过程的有限元动力学仿真;然后对仿真结果进行了分析,并初步得出了天线板的刚度和强度是符合要求的结论;最后,提出了如何提高天线板刚度和强度的措施,如合理设计框架的梁、应用新材料等措施。     

光电技术产业发展现状及其对策

光电技术产业作为21世纪的朝阳产业,被很多专业人士及国家所看好。甚至有专家认为,一个国家光电产业的发展如何、发达与否,已成为衡量一个国家综合国力的重要标尺。文章简要阐述了当前全球及我国、本省和扬州地区光电产业的发展状况,并提出相应对策。这些研究,将对推动本地区光电产业发展提供重要依据。     

浅谈我国铁路通信信号发展趋势

随着信息时代的到来,铁路的发展也在日新月异的变化着,铁路通信信号的发展趋势正在向一体化、多信息化、功能集成化、高度自动化的方向前进。文章主要从计算机联锁设备、列车自动控制系统、调度指挥系统三个部分对信号系统进行了分析和阐述。     

Introducing an External Terminal Operator or Not? The Decision of Ports in a Duopoly Market

Facing with increasing competition, many ports are taking innovative approaches to improve productivity and profits. Among a variety of methods, introducing external terminal operators(ETOs) while the port acts as a landlord to collect "rents" from those operators for conducting terminal activities inside the port is regarded as an effective way and is commonly observed in practices.This paper analyzes the decisions of two competing ports about whether to introduce their respective ETOs using a three-stage non-cooperative game model when there already exists a port's self-operation terminal operator(STO). At the first stage, the two ports simultaneously decide whether to introduce an ETO. If a port decided to introduce an ETO, at the second stage, it will further decide the unit fee to charge from the ETO. At the third stage, the two ports and the introduced ETO(s) simultaneously decide their respective profit-maximizing output levels. The findings indicate the equilibrium is both ports will introduce their respective ETOs, but when the ports and ETOs are substitutable in the sense of having the same level of productivity, the equilibrium solution is only one port should introduce an ETO. And simulation results show that even if one of ETOs is inefficient this still hold true.     

The industrial asymmetry of the stock price prediction with investor sentiment: Based on the comparison of predictive effects with SVR

As a representative emerging financial market, the Chinese stock market is more prone to volatility because of investor sentiment. It is reasonable to use efficient predictive methods to analyze the influence of investor sentiment on stock price forecasting. This paper conducts a comparative study about the predictive performance of artificial neural network, support vector regression (SVR) and autoregressive integrated moving average and selects SVR to study the asymmetry effect of investor sentiment on different industry index predictions. After studying the relevant financial indicators, the results divide the Shenwan first-class industries into two types and show that the industries affected by investor sentiment are composed of young companies with high growth and high operative pressure and there are a great number of investment bubbles in those companies.     

Defining G protein-coupled receptor peptide ligand expressomes and signalomes in human and mouse islets

Introduction

Islets synthesise and secrete numerous peptides, some of which are known to be important regulators of islet function and glucose homeostasis. In this study, we quantified mRNAs encoding all peptide ligands of islet G protein-coupled receptors (GPCRs) in isolated human and mouse islets and carried out in vitro islet hormone secretion studies to provide functional confirmation for the species-specific role of peptide YY (PYY) in mouse islets.

Materials and methods

GPCR peptide ligand mRNAs in human and mouse islets were quantified by quantitative real-time PCR relative to the reference genes ACTB, GAPDH, PPIA, TBP and TFRC. The pathways connecting GPCR peptide ligands with their receptors were identified by manual searches in the PubMed, IUPHAR and Ingenuity databases. Distribution of PYY protein in mouse and human islets was determined by immunohistochemistry. Insulin, glucagon and somatostatin secretion from islets was measured by radioimmunoassay.

Results

We have quantified GPCR peptide ligand mRNA expression in human and mouse islets and created specific signalomes mapping the pathways by which islet peptide ligands regulate human and mouse GPCR signalling. We also identified species-specific islet expression of several GPCR ligands. In particular, PYY mRNA levels were ~ 40,000-fold higher in mouse than human islets, suggesting a more important role of locally secreted Pyy in mouse islets. This was confirmed by IHC and functional experiments measuring insulin, glucagon and somatostatin secretion.

Discussion

The detailed human and mouse islet GPCR peptide ligand atlases will allow accurate translation of mouse islet functional studies for the identification of GPCR/peptide signalling pathways relevant for human physiology, which may lead to novel treatment modalities of diabetes and metabolic disease.

     

Genome-wide association studies of 14 agronomic traits in rice landraces

Uncovering the genetic basis of agronomic traits in crop landraces that have adapted to various agro-climatic conditions is important to world food security. Here we have identified ～ 3.6 million SNPs by sequencing 517 rice landraces and constructed a high-density haplotype map of the rice genome using a novel data-imputation method. We performed genome-wide association studies (GWAS) for 14 agronomic traits in the population of Oryza sativa indica subspecies. The loci identified through GWAS explained ～ 36% of the phenotypic variance, on average. The peak signals at six loci were tied closely to previously identified genes. This study provides a fundamental resource for rice genetics research and breeding, and demonstrates that an approach integrating second-generation genome sequencing and GWAS can be used as a powerful complementary strategy to classical biparental cross-mapping for dissecting complex traits in rice.     

Genome-wide association study of flowering time and grain yield traits in a worldwide collection of rice germplasm

A high-density haplotype map recently enabled a genome-wide association study (GWAS) in a population of indica subspecies of Chinese rice landraces. Here we extend this methodology to a larger and more diverse sample of 950 worldwide rice varieties, including the Oryza sativa indica and Oryza sativa japonica subspecies, to perform an additional GWAS. We identified a total of 32 new loci associated with flowering time and with ten grain-related traits, indicating that the larger sample increased the power to detect trait-associated variants using GWAS. To characterize various alleles and complex genetic variation, we developed an analytical framework for haplotype-based de novo assembly of the low-coverage sequencing data in rice. We identified candidate genes for 18 associated loci through detailed annotation. This study shows that the integrated approach of sequence-based GWAS and functional genome annotation has the potential to match complex traits to their causal polymorphisms in rice.     

A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis

To identify susceptibility loci for ankylosing spondylitis, we performed a two-stage genome-wide association study in Han Chinese. In the discovery stage, we analyzed 1,356,350 autosomal SNPs in 1,837 individuals with ankylosing spondylitis and 4,231 controls; in the validation stage, we analyzed 30 suggestive SNPs in an additional 2,100 affected individuals and 3,496 controls. We identified two new susceptibility loci between EDIL3 and HAPLN1 at 5q14.3 (rs4552569; P = 8.77 × 10(-10)) and within ANO6 at 12q12 (rs17095830; P = 1.63 × 10(-8)). We also confirmed previously reported associations in Europeans within the major histocompatibility complex (MHC) region (top SNP, rs13202464; P < 5 × 10(-324)) and at 2p15 (rs10865331; P = 1.98 × 10(-8)). We show that rs13202464 within the MHC region mainly represents the risk effect of HLA-B*27 variants (including HLA-B*2704, HLA-B*2705 and HLA-B*2715) in Chinese. The two newly discovered loci implicate genes related to bone formation and cartilage development, suggesting their potential involvement in the etiology of ankylosing spondylitis.