12CaO·7Al2O3型精炼合成渣物性与脱硫试验

对近两年从国外发展起来的新型精炼合成渣 12 Ca O· 7Al2 O3的烧成工艺、物性和脱硫能力进行了试验研究。结果表明 ,该渣系原料来源广泛 ,成本较低 ;以 12 Ca O· 7Al2 O3为低熔点相 ,具有较低的熔化温度 ,在精炼温度下具有较好的流动性 ;由于具有很高的碱度和 Al2 O3含量 ,因而具有较强的脱硫能力和吸附铝脱氧产物的能力 ,并且在精炼过程中还可配加大量石灰 ,进一步提高其脱硫能力 ,尤其适用于铝脱氧钢     

基本养老保险关系转移持续探讨

2010年伊始实行的<城镇企业职工基本养老关系转移持续办法暂行办法>为我国跨地区养老保险关系实现顺畅转移提供了可能,但是在其实践过程中却存在参保与收益水平差异、异地对接困难、自我流动难以转移等问题.经过研究分析,认为只有采取加强政府间协调、加快社保信息化建设、提高经办人员素质、加大宣传力度等,新办法才能不断完善,促进我国社会保障制度的进步.     

Introducing an External Terminal Operator or Not? The Decision of Ports in a Duopoly Market

Facing with increasing competition, many ports are taking innovative approaches to improve productivity and profits. Among a variety of methods, introducing external terminal operators(ETOs) while the port acts as a landlord to collect "rents" from those operators for conducting terminal activities inside the port is regarded as an effective way and is commonly observed in practices.This paper analyzes the decisions of two competing ports about whether to introduce their respective ETOs using a three-stage non-cooperative game model when there already exists a port's self-operation terminal operator(STO). At the first stage, the two ports simultaneously decide whether to introduce an ETO. If a port decided to introduce an ETO, at the second stage, it will further decide the unit fee to charge from the ETO. At the third stage, the two ports and the introduced ETO(s) simultaneously decide their respective profit-maximizing output levels. The findings indicate the equilibrium is both ports will introduce their respective ETOs, but when the ports and ETOs are substitutable in the sense of having the same level of productivity, the equilibrium solution is only one port should introduce an ETO. And simulation results show that even if one of ETOs is inefficient this still hold true.     

The industrial asymmetry of the stock price prediction with investor sentiment: Based on the comparison of predictive effects with SVR

As a representative emerging financial market, the Chinese stock market is more prone to volatility because of investor sentiment. It is reasonable to use efficient predictive methods to analyze the influence of investor sentiment on stock price forecasting. This paper conducts a comparative study about the predictive performance of artificial neural network, support vector regression (SVR) and autoregressive integrated moving average and selects SVR to study the asymmetry effect of investor sentiment on different industry index predictions. After studying the relevant financial indicators, the results divide the Shenwan first-class industries into two types and show that the industries affected by investor sentiment are composed of young companies with high growth and high operative pressure and there are a great number of investment bubbles in those companies.     

Defining G protein-coupled receptor peptide ligand expressomes and signalomes in human and mouse islets

Introduction

Islets synthesise and secrete numerous peptides, some of which are known to be important regulators of islet function and glucose homeostasis. In this study, we quantified mRNAs encoding all peptide ligands of islet G protein-coupled receptors (GPCRs) in isolated human and mouse islets and carried out in vitro islet hormone secretion studies to provide functional confirmation for the species-specific role of peptide YY (PYY) in mouse islets.

Materials and methods

GPCR peptide ligand mRNAs in human and mouse islets were quantified by quantitative real-time PCR relative to the reference genes ACTB, GAPDH, PPIA, TBP and TFRC. The pathways connecting GPCR peptide ligands with their receptors were identified by manual searches in the PubMed, IUPHAR and Ingenuity databases. Distribution of PYY protein in mouse and human islets was determined by immunohistochemistry. Insulin, glucagon and somatostatin secretion from islets was measured by radioimmunoassay.

Results

We have quantified GPCR peptide ligand mRNA expression in human and mouse islets and created specific signalomes mapping the pathways by which islet peptide ligands regulate human and mouse GPCR signalling. We also identified species-specific islet expression of several GPCR ligands. In particular, PYY mRNA levels were ~ 40,000-fold higher in mouse than human islets, suggesting a more important role of locally secreted Pyy in mouse islets. This was confirmed by IHC and functional experiments measuring insulin, glucagon and somatostatin secretion.

Discussion

The detailed human and mouse islet GPCR peptide ligand atlases will allow accurate translation of mouse islet functional studies for the identification of GPCR/peptide signalling pathways relevant for human physiology, which may lead to novel treatment modalities of diabetes and metabolic disease.

     

Genome-wide association studies of 14 agronomic traits in rice landraces

Uncovering the genetic basis of agronomic traits in crop landraces that have adapted to various agro-climatic conditions is important to world food security. Here we have identified ～ 3.6 million SNPs by sequencing 517 rice landraces and constructed a high-density haplotype map of the rice genome using a novel data-imputation method. We performed genome-wide association studies (GWAS) for 14 agronomic traits in the population of Oryza sativa indica subspecies. The loci identified through GWAS explained ～ 36% of the phenotypic variance, on average. The peak signals at six loci were tied closely to previously identified genes. This study provides a fundamental resource for rice genetics research and breeding, and demonstrates that an approach integrating second-generation genome sequencing and GWAS can be used as a powerful complementary strategy to classical biparental cross-mapping for dissecting complex traits in rice.     

Mutations in ISPD cause Walker-Warburg syndrome and defective glycosylation of α-dystroglycan

Walker-Warburg syndrome (WWS) is an autosomal recessive multisystem disorder characterized by complex eye and brain abnormalities with congenital muscular dystrophy (CMD) and aberrant a-dystroglycan glycosylation. Here we report mutations in the ISPD gene (encoding isoprenoid synthase domain containing) as the second most common cause of WWS. Bacterial IspD is a nucleotidyl transferase belonging to a large glycosyltransferase family, but the role of the orthologous protein in chordates is obscure to date, as this phylum does not have the corresponding non-mevalonate isoprenoid biosynthesis pathway. Knockdown of ispd in zebrafish recapitulates the human WWS phenotype with hydrocephalus, reduced eye size, muscle degeneration and hypoglycosylated a-dystroglycan. These results implicate ISPD in a-dystroglycan glycosylation in maintaining sarcolemma integrity in vertebrates.