Bounding the inefficiency of the C-logit stochastic user equilibrium assignment

Compared with standard logit-based stochastic user equilibrium assignment model, the C-logit model describes route choice behavior in a more realistic way by considering the overlapping effect between routes. This paper investigates the inefficiency upper bounds of this model against the deterministic system optimum and the C-logit stochastic system optimum in terms of the total network travel time. It is found that the commonality factor of overlapping routes significantly affects the inefficiency bound, besides link congestion degree, total demand and the number of feasible routes. If the commonality factor is not considered, the efficiency loss resulting from selfishly stochastic travel behavior will be to large extent underestimated.     

安全性第一准则下的组合贷款模型

提出了一种在概率准则意义下的组合贷款模型,并设计了基于随机模拟的混合优化算法进行求解。 该算法突破了各种贷款收益率必须服从正态分布的假定,可对贷款收益率是任意分布形式的模型进行求解。 经数值仿真,验证了算法的可行性。     

铁矿粉湿容量的概念及其在制粒过程中的应用

适宜的配水量对改善铁矿粉的制粒效果起重要作用。为建立一种简单易行、准确合理的方法,提出了铁矿粉湿容量的概念,即单位质量的矿物在自然堆积的状态下所能保持的最大含水量,并开发出相关测试设备。利用该方法对来自某实际生产过程中的5组混合料进行了测试,得到了每组混合料的湿容量。在实验室规模的设备上进行了5组混合料在不同配水量条件下的制粒实验,并对其透气性进行了检测,得到了每组原料的最佳配水量。对比每组混合料的湿容量和最佳配水量发现：两个参数之间具有很强的正相关性,湿容量大的混合料需要配加更多的水后料层才能达到最佳的制粒效果。还对料层的透气性和粒度分布关系做了讨论。实验发现随着加水量的增多,颗粒制粒后的粒度逐渐增大,料层的透气性先增大后减小。     

The structure-based design of zinc finger nucleases can facilitate genomic editing

A recent study of significant research value carried out at the State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou,     

基于结构光立体视觉的激光再制造工件的测量

为了实现激光再制造工件的快速准确测量,提出了1套与激光再制造机器人耦合的视觉系统.该视觉系统由2个摄像机、1个激光投射器和计算机组成.摄像机和激光投射器组成扫描测头,由6自由度机器人手持实现多视角扫描.并自动完成数据拼接,消除‘死角'.首先,通过MATLAB编程完成系统标定,分别标定出单目摄像机内外参数矩阵,双目相机关...     

金洞森林旅游开发的前景及效益分析

文章从发展生态旅游入手,结合当前森林旅游形势的需要,从社会基础、自然条件、区位优势与资源优势进行分析,以突出金洞的本土特色,提出合理的建设原则,并设计相应的森林旅游项目,从实际出发提出可行的开发形式与管理办法,通过效益分析得出开发森林旅游的可行性结论。     

A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis

To identify susceptibility loci for ankylosing spondylitis, we performed a two-stage genome-wide association study in Han Chinese. In the discovery stage, we analyzed 1,356,350 autosomal SNPs in 1,837 individuals with ankylosing spondylitis and 4,231 controls; in the validation stage, we analyzed 30 suggestive SNPs in an additional 2,100 affected individuals and 3,496 controls. We identified two new susceptibility loci between EDIL3 and HAPLN1 at 5q14.3 (rs4552569; P = 8.77 × 10(-10)) and within ANO6 at 12q12 (rs17095830; P = 1.63 × 10(-8)). We also confirmed previously reported associations in Europeans within the major histocompatibility complex (MHC) region (top SNP, rs13202464; P < 5 × 10(-324)) and at 2p15 (rs10865331; P = 1.98 × 10(-8)). We show that rs13202464 within the MHC region mainly represents the risk effect of HLA-B*27 variants (including HLA-B*2704, HLA-B*2705 and HLA-B*2715) in Chinese. The two newly discovered loci implicate genes related to bone formation and cartilage development, suggesting their potential involvement in the etiology of ankylosing spondylitis.     

A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia

Non-obstructive azoospermia (NOA) is one of the most severe forms of male infertility. Its pathophysiology is largely unknown, and few genetic influences have been defined. To identify common variants contributing to NOA in Han Chinese men, we performed a three-stage genome-wide association study of 2,927 individuals with NOA and 5,734 controls. The combined analyses identified significant (P < 5.0 × 10(-8)) associations between NOA risk and common variants near PRMT6 (rs12097821 at 1p13.3: odds ratio (OR) = 1.25, P = 5.7 × 10(-10)), PEX10 (rs2477686 at 1p36.32: OR = 1.39, P = 5.7 × 10(-12)) and SOX5 (rs10842262 at 12p12.1: OR = 1.23, P = 2.3 × 10(-9)). These findings implicate genetic variants at 1p13.3, 1p36.32 and 12p12.1 in the etiology of NOA in Han Chinese men.     

Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the somatically mutated genes in a prevalence set of 88 additional individuals with TCC with different tumor stages and grades. In our study, we discovered a variety of genes previously unknown to be mutated in TCC. Notably, we identified genetic aberrations of the chromatin remodeling genes (UTX, MLL-MLL3, CREBBP-EP300, NCOR1, ARID1A and CHD6) in 59% of our 97 subjects with TCC. Of these genes, we showed UTX to be altered substantially more frequently in tumors of low stages and grades, highlighting its potential role in the classification and diagnosis of bladder cancer. Our results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer.