Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells

Although immune mechanisms can suppress tumour growth, tumours establish potent, overlapping mechanisms that mediate immune evasion. Emerging evidence suggests a link between angiogenesis and the tolerance of tumours to immune mechanisms. Hypoxia, a condition that is known to drive angiogenesis in tumours, results in the release of damage-associated pattern molecules, which can trigger the rejection of tumours by the immune system. Thus, the counter-activation of tolerance mechanisms at the site of tumour hypoxia would be a crucial condition for maintaining the immunological escape of tumours. However, a direct link between tumour hypoxia and tolerance through the recruitment of regulatory cells has not been established. We proposed that tumour hypoxia induces the expression of chemotactic factors that promote tolerance. Here we show that tumour hypoxia promotes the recruitment of regulatory T (T(reg)) cells through induction of expression of the chemokine CC-chemokine ligand 28 (CCL28), which, in turn, promotes tumour tolerance and angiogenesis. Thus, peripheral immune tolerance and angiogenesis programs are closely connected and cooperate to sustain tumour growth.     

全面质量管理在军队院校教育的可行性分析

从管理思想,管理模式和管理文化对全面质量管理与军队院校管理进行了比较．讨论分析了将全面质量管理引入军队院校管理的可行性。     

Analysis of asymptotically tight approximation SER for cooperative NOMA systems

The closed-form formula derivation of the power domain cooperative non-orthogonal multiple access(NOMA) system is of great significance for further improving the performance of the system.However,the system performance formulas of the channel capacity and the paired bit error rate pairwise error probability(PEP) are too complicated,which have increased the difficulty in system performance optimization.Therefore,based on the amplify forward(AF) relay cooperative NOMA model,the signal interference noise ratio(SINR) formulas of the two user nodes are constructed.Through the assumption of that,the symbol error rate(SER) of each user is fair,the simplification condition of moment generating function(MGF) with the harmonic mean form is satisfied.Combined with the SER calculation formula of MGF,the system SER asymptotically tight approximation formula with simple structure is derived at high signal-to-noise ratio(SNR).The Monte Carlo simulation results show that,the formula can accurately describe the SER performance of the power domain cooperative NOMA system with the non-ideal successive interference cancellation(SIC) system when SNR is high.Under the condition of certain total power,the optimal power allocation factor is solved in order to minimize the total system SER.     

Mn:Fe:LiNbO3晶体全息存储的研究

本文用双光子记录法测试Mn:Fe:LiNbO3晶体二波耦合衍射效率.分别用绿光和红光作为记录光,紫外光作为选通光进行全息记录.用绿光作为记录光比用红光作为记录光得到的全息记录灵敏度提高约一个数量级,并且动态范围也有一定的提高.对记录光、选通光的作用和双掺杂Mn:Fe:LiNbO3晶体双光子全息存储的机理进行研究.     

田径训练短跑运动员生理机能评定及负荷诊断

运动员的身体机能评定是合理制定训练计划、确定训练指标、安排训练负荷的依据,是运动员创造运动成绩的生理基础.准确地掌握运动员的身体机能状态,是为了更好地完成训练任务.负荷是由负荷量和负荷强度所组成,反映训练的数量和质量的特征.     

一种求解非线性约束优化问题的新方法

针对标准遗传算法的缺陷,提出一种基于实数编码技术的新型自适应混沌遗传算法,求解复杂非线性约束优化问题.算法根据实数编码的特点,依据概率分布函数构造杂交算子,结合混沌动力学特性和人工神经网络理论,设计了一种自适应混沌变异算子,使算法有效维持群体多样性,防止和克服进化中的“早熟”现象,同时采用不需要惩罚因子的直接比较惩罚函数方法,对约束条件加以处理.通过算例数值实验,验证了算法在提高解的精度和加快收敛速度方面都有明显改善.     

A novel fully-integrated miniature six-axis force/torque sensor

This paper presents a new designed miniature six DOF （degree of freedom） force/torque sensor. This sensor is fully integrated with a micro DSP （digital signal processor）, so all the signal conditioning, A/D, decoupling, digital-signals serial output are performed in the sensor. Some experimental results are presented to demonstrate the capability of the proposed design. Finally, a neural network was used for decoupling the interacting signals, compared with the conventional method using the inverse matrix, this new method is more accurate.     

Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the somatically mutated genes in a prevalence set of 88 additional individuals with TCC with different tumor stages and grades. In our study, we discovered a variety of genes previously unknown to be mutated in TCC. Notably, we identified genetic aberrations of the chromatin remodeling genes (UTX, MLL-MLL3, CREBBP-EP300, NCOR1, ARID1A and CHD6) in 59% of our 97 subjects with TCC. Of these genes, we showed UTX to be altered substantially more frequently in tumors of low stages and grades, highlighting its potential role in the classification and diagnosis of bladder cancer. Our results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer.     

自调式镦压挤胀复合液压机的研制

从力学原理、设计原理、整机结构、关键零部件的设计和工作程序,系统地介绍了自调式镦压挤胀复合液压机．由于压机设计了顶出缸对下活动横梁调节限位结构,回程拉杆对上镦压横梁的复位结构及镦压缸和气液储能器之间的连通协调结构,这不仅使该液压机结构紧凑,同时节省了上镦压横梁的回程液压缸、下活动横梁的镦压缸,并简化了上凸模与上镦压模分设的液压系统,而且解决了直齿圆柱齿轮在塑性成形过程中齿顶难以充满、齿根易出现微裂纹,以及成形压力过大和模具寿命过低的问题．     

Long Text Classification Algorithm Using a Hybrid Model of Bidirectional Encoder Representation from Transformers-Hierarchical Attention Networks-Dilated Convolutions Network

Text format information is full of most of the resources of Internet,which puts forward higher and higher requirements for the accuracy of text classification.T...