Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass

Genetic and pharmacological studies have defined a role for the melanocortin-4 receptor (Mc4r) in the regulation of energy homeostasis. The physiological function of Mc3r, a melanocortin receptor expressed at high levels in the hypothalamus, has remained unknown. We evaluated the potential role of Mc3r in energy homeostasis by studying Mc3r-deficient (Mc3r(-/-)) mice and compared the functions of Mc3r and Mc4r in mice deficient for both genes. The 4-6-month Mc3r-/- mice have increased fat mass, reduced lean mass and higher feed efficiency than wild-type littermates, despite being hypophagic and maintaining normal metabolic rates. (Feed efficiency is the ratio of weight gain to food intake.) Consistent with increased fat mass, Mc3r(-/-) mice are hyperleptinaemic and male Mc3r(-/-) mice develop mild hyperinsulinaemia. Mc3r(-/-) mice did not have significantly altered corticosterone or total thyroxine (T4) levels. Mice lacking both Mc3r and Mc4r become significantly heavier than Mc4r(-/-) mice. We conclude that Mc3r and Mc4r serve non-redundant roles in the regulation of energy homeostasis.     

超声在未破裂型宫外孕诊断中的作用

目的探讨超声对未破裂型宫外孕诊断的价值。方法回顾分析280例B超首诊宫外孕患者的临床、超声检查及手术病理资料。结果全部病例均显示附件区包块,其中257例经病理证实为宫外孕,23例经随访确诊为早期宫内妊娠合并黄体囊肿。结论超声检查在未破裂型宫外孕诊断中具有较大的临床应用价值,但需与孕早期黄体囊肿鉴别。     

基于协同理论的模糊多因素消防安全决策模型

为了选择降低火灾风险的消防安全隐患治理方案,针对消防安全决策具有多因素制约的特征,结合协同理论和模糊数学方法,构建了消防安全隐患治理方案的多因素决策模型。通过确定消防安全隐患治理方案的评选因素及各评选因素的权重,采用消防安全隐患治理方案决策模型获得最优的消防安全隐患治理方案。以苏州市古城区为研究对象,提出了三种消防安全隐患治理方案,采用构建的决策模型进行消防安全决策。结果表明:该决策模型能够反映消防安全隐患治理方案的效果、投资和工期。采用该决策模型优选获得的消防安全隐患治理方案符合古城区区域火灾风险实际,验证了其实用性。     

Numerical simulation of blasting effect with divided charge structure

This paper numerically simulates the stress development and generates a three-dimensional model of the medium-length hole blasting in infinite rock mass for continuous charge and divided charge in blasting by us- ing the large-scale nonlinear dynamic analysis software LS-DYNA and the elastic-plastic model ＊MAT_PLAS- TIC_KINEMATIC and JWO-EOS. The differences of the decreasing rate in Von Mises effective stress of blas- ting, element effective stress peak of free surface, bore wall stress and acceleration are investigated. It is shown that divided charge could greatly improve the blasting effect by engineering blasting practice.     

不同苹果品种抗寒性的研究

为了检测适宜加工苹果不同品种在石河子的抗寒适应性,筛选适宜在石河子地区大面积推广的加工苹果品种,采用试验室模拟田间低温环境方法对8个苹果品种1年生枝条分别在4、-15、-20、-25、-30、-35℃条件下进行预处理,并对其相对电导率并计算临界半致死温度(LT40)、可溶性蛋白、脯氨酸及丙二醛含量进行研究。结果显示,经过不同梯度低温处理后,寒富、国光的萌芽率显著较高;相对电导率显著较低;国光丙二醛含量显著性较低;寒富的脯氨酸含量与可溶性蛋白含量显著较高。结论:苹果枝条经过低温胁迫后,寒富、国光、甜格力在石河子地区抗寒能力较好。     

固体饮料中合成色素前处理方法的研究

测定固体饮料中合成色素柠檬黄、日落黄时分别以国标中聚酰胺吸附法和液-液分配法进行样品前处理,并通过精密度和样品回收率对检测结果予以比较,两种前处理方法检测结果无明显差异,液-液分配法在检测大批量样品时具有一定的优势.     

关于丢番图方程x3±53=3py2

设P为奇素数,运用同余式、平方剩余、乐让德符号的性质等初等方法得出了丢番图方程x^3±5^3=3py^2无正整数解的两个充分条件．     

供应不确定下承诺定价策略与响应定价策略的对比研究

【目的】为了提高供应不确定下零售商的定价决策的科学性,比较承诺定价与响应定价两种策略的优劣。【方法】构建随机非线性规划模型,利用最优化理论和逆向归纳求解法,刻画了两种策略下的最优定价与订购决策,并进行了数值分析。【结果】数值分析结果表明:两种策略的优劣取决于其相应的需求量之差与实际实现的供应量。【结论】在供应不确定条件下,响应定价不一定比承诺定价更优,决策者应权衡好响应定价的便利和其带来的需求减少的风险。