A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis

To identify susceptibility loci for ankylosing spondylitis, we performed a two-stage genome-wide association study in Han Chinese. In the discovery stage, we analyzed 1,356,350 autosomal SNPs in 1,837 individuals with ankylosing spondylitis and 4,231 controls; in the validation stage, we analyzed 30 suggestive SNPs in an additional 2,100 affected individuals and 3,496 controls. We identified two new susceptibility loci between EDIL3 and HAPLN1 at 5q14.3 (rs4552569; P = 8.77 × 10(-10)) and within ANO6 at 12q12 (rs17095830; P = 1.63 × 10(-8)). We also confirmed previously reported associations in Europeans within the major histocompatibility complex (MHC) region (top SNP, rs13202464; P < 5 × 10(-324)) and at 2p15 (rs10865331; P = 1.98 × 10(-8)). We show that rs13202464 within the MHC region mainly represents the risk effect of HLA-B*27 variants (including HLA-B*2704, HLA-B*2705 and HLA-B*2715) in Chinese. The two newly discovered loci implicate genes related to bone formation and cartilage development, suggesting their potential involvement in the etiology of ankylosing spondylitis.     

面向突发事件的电网韧性能力评价及构建方法

近年来,我国对电力系统面对突发事件时的性能表现提出了更为严格的要求,利用韧性的概念构建电网系统能够实现应急全周期内避免损失.文章利用应急管理理论分阶段刻画韧性的特征,在描述突发事件下电网韧性能力的同时提出了一种定量评价电网韧性的方法,它侧重于电网在突发事件发生后随着时间的推移维持稳定、抵抗中断、恢复性能的调整能力:利用给出的韧性评价指数结合电网特有的包括运行模式、组件物理强度和网络拓扑结构在内的电网特征,针对性地描述了能够增强电网韧性的措施.最后举例选取N-1准则措施利用PSCAD软件进行仿真模拟,利用韧性评价指数说明N-1措施能够增强电网韧性的同时,验证了韧性评价指数的合理性.电网实例引用IEEE14节点模型.     

企业员工E-Learning接受意向影响因素研究

企业员工对E-Learning的接受意向影响着E-Learning培训的有效性。本文在技术接受模型(TAM)的基础上结合E-Learning的特点,建立了企业员工E-Learning接受意向影响因素理论模型并提出相应假设。通过对采用E-Learning培训方式的企业员工进行问卷调查获取数据后,利用结构方程模型对研究假设进行检验并对理论模型予以修正。结果表明,技术特性、个体特性和组织支持都能通过个体感知因素间接影响行为意向,感知易用性对行为意向既能产生值接作用,又能通过感知有用性产生间接影响,是行为意向最重要的影响因素。最终根据研究结论对企业有效引入和实施E-Learning提出了建议。     

Hybrid particle swarm optimization for multiobjective resource allocation

Resource allocation （RA） is the problem of allocating resources among various artifacts or business units to meet one or more expected goals, such a.s maximizing the profits, minimizing the costs, or achieving the best qualities. A complex multiobjective RA is addressed, and a multiobjective mathematical model is used to find solutions efficiently. Then, all improved particie swarm algorithm （mO_PSO） is proposed combined with a new particle diversity controller policies and dissipation operation. Meanwhile, a modified Pareto methods used in PSO to deal with multiobjectives optimization is presented. The effectiveness of the provided algorithm is validated by its application to some illustrative example dealing with multiobjective RA problems and with the comparative experiment with other algorithm.     

"大系统"理论及其在温室系统建模中的应用

在简介现代系统工程发展的基础上,引入了“大系统”的基本概念,综述了“大系统”理论的特征,分类和大系统的控制邮将“大系统”理论应用到温室系统建立综合动态仿真模型中的思路,最后对建模方法进行了探讨。     

多措并举促进电力企业安全管理

电力安全生产关系到国家的财产安全、人民生活利益和电力职工的安康,是电力企业最根本的效益所在.电力安全生产是电力企业生存和发展的基石,影响着电力企业本身的内外形象,在我国经济社会正处于高速发展的大好时期,电力生产安全管理显得尤为重要.     

乒乓球专项课四段指标教学模式的建构与实践应用研究

为深化乒乓球专项课教学改革,全面提升乒乓球专项人才培养质量,运用专家访谈法、实验法和数理统计法等方法,以四段指标评估法为理论基础,对如何将该方法的精髓进行创造性的引入、转化以及如何应用于高校乒乓球专项课教学中进行了系统、深入的理论探索和实验研究.研究认为:①四段指标教学模式能更充分地激发学生的学习兴趣,更有效地提升学生...     

采空区高硫煤自燃阻化技术试验分析

针对常用矿用阻化剂进行阻化实验,根据阻化效率、成本、溶解度等因素选出Na2CO3作为试验工作面的阻化剂,从隔绝氧气、吸热降温和负催化作用3个方面对Na2CO3阻化液的阻化机理进行分析.设计阻化液在试验工作面的制备工艺、钻孔布置和注液系统,使得每个注液孔有40 min的注液时间,从而避免了采煤与阻化作业相互影响；对预注阻化液前后试验工作面采空区内的气体体积分数和温度分布进行分析.研究结果表明:氧化区域位于采空区进风侧,在预注阻化液后,气体体积分数和温度分布明显降低；在预注阻化液后,煤的氧化进程推后11d左右,从而降低了自燃危险性,有利于试验工作面采空区防灭火.     

Coordinating production and recycling decisions with stochastic demand and return

In this paper, the joint production and recycling problem is investigated for a hybrid manufacturing and remanufacturing system where brand-new products are produced in the manufacturing plant and recycled products are remanufactured into as-new products in the remanufacturing facility. Both the brand-new products and remanufactured products are used to satisfy customer demands. Returns of used products that are recycled from customers are assumed to be stochastic and nonlinearly price-dependent. A mathematical model is proposed to maximize the overall profit of the system through simultaneously optimizing the production and recycling decisions, subject to two capacity constraints — the manufacturing capacity and the remanufacturing capacity. Based on Lagrangian relaxation method, subgradient algorithm and heuristic algorithm, a solution approach is developed to solve the problem. A representative example is presented to illustrate the system, and managerial analysis indicates that the uncertainties in demand and return have much influence on the production and recycling policy. In addition, twenty randomly produced examples are solved, and computational results show that the solution approach can obtain very good solutions for all examples in reasonable time.     

A combination of leaf rust resistance gene Lr34 and lesion mimic gene lm significantly enhances adult plant resistance to Puccinia triticina in wheat

Leaf rust caused by Puccinia triticina is an economically-important disease in wheat worldwide.A combination of different types of resistance genes may significantly enhance rust resistance under rust-favorable conditions.To investigate the interactions between the rust resistance gene Lr34 and the lesion mimic gene lm on 1BL in Ning 7840,a segregating F8-10 population of 180 recombinant inbred lines was developed from Ning 7840/Chokwang and evaluated for both lesion mimic expression and leaf rust response at the adult plant stage in a greenhouse.A major quantitative trait locus(QTL),derived from Sumai 3,was co-localized with Lr34 on chromosome 7D and explained 41.5% of phenotypic variations for rust severity and 22.1% for leaf tip necrosis(LTN).The presence of Lr34 was confirmed by Lr34-specific markers cssfr1 and cssfr2 in Ning 7840 and Sumai 3.Unlike Lr34,lm conditioned a spontaneous lesion mimic phenotype and had a significant effect on reducing uredinial size,and a smaller effect on severity.Additive effects were observed between lm and Lr34 for severity and LTN,and an epistatic effect was observed for infection type.Single marker analysis also identified several other QTL with minor effects on severity,infection type,or LTN.