Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting.

Interleukin-2 (IL-2) is a lymphocytotropic hormone which is thought to have a key role in the immune response of mammalian cells. It is produced by a subpopulation of activated T-lymphocytes and acts in vitro as the principal auto- and paracrine T-cell growth factor (for reviews see refs 1-3). IL-2 is, however, not the sole T-cell growth factor, nor does it act exclusively on T cells, also promoting growth of NK cells and differentiation of B cells. A role for IL-2 in T-cell development has been postulated but remains controversial. Here we test the requirement for IL-2 in vivo using IL-2-deficient mice generated by targeted recombination. We find that mice homozygous for the IL-2 gene mutation are normal with regard to thymocyte and peripheral T-cell subset composition, but that a dysregulation of the immune system is manifested by reduced polyclonal in vitro T-cell responses and by dramatic changes in the isotype levels of serum immunoglobulins.     

人性假设与企业人力资源管理

人性假设是许多社会科学领域研究的出发点 ,企业也常常从自己的人性假设出发形成企业人力资源管理的理念。基于不同的人性假设 ,中国古代哲学、近现代西方经济学和管理学分别提出了对社会治理和企业治理的看法。在总结与分析的基础上 ,我们提出一种“混沌人”的假设。     

萃取浮选光度法测定微量钼的研究及应用

研究了用甲苯萃取浮选Mo(Ⅴ)—SCN~-—Kφ三元络合物的各种条件。在硫酸介质中,紫红色络合物最大吸收波长位于585nm,摩尔吸光系数为2.8×10~5l·mol~(-1)·cm~(-1),钼量在0—10μg/25ml范围内符合比耳定律。大量常见元素均不干扰,40倍的钨(Ⅵ)亦不干扰钼的测定,方法已应用于钨矿中微量钼的测定,其结果令人满意。     

The Huntington's disease candidate region exhibits many different haplotypes.

Analysis of 78 Huntington's disease (HD) chromosomes with multi-allele markers revealed 26 different haplotypes, suggesting a variety of independent HD mutations. The most frequent haplotype, accounting for about one third of disease chromosomes, suggests that the disease gene is between D4S182 and D4S180. However, the paucity of an expected class of chromosomes that can be related to this major haplotype by assuming single crossovers may reflect the operation of other mechanisms in creating haplotype diversity. Some of these mechanisms sustain alternative scenarios that do not require a multiple mutational origin for HD and/or its positioning between D4S182 and D4S180.     

广西农业专家系统的建立和应用

广西农业专家系统的开发建设主要集中在基础数据库建设、知识库建设、人机界面的设计和改进方面。该系统建有农业气象数据库、土壤数据库、品种数据库和病虫害数据库以及龙眼专家系统、荔枝专家系统、果专家系统和甘蔗专家系统。这些农业专家系统在广西30个县 (市 )进行示范种植 (示范面积 6 .5 0× 10 4hm2 ) ,获得了增产增收、降低生产成本的效果。