全文获取类型
收费全文 | 195篇 |
免费 | 1篇 |
专业分类
系统科学 | 13篇 |
教育与普及 | 1篇 |
理论与方法论 | 3篇 |
现状及发展 | 27篇 |
研究方法 | 30篇 |
综合类 | 121篇 |
自然研究 | 1篇 |
出版年
2024年 | 1篇 |
2022年 | 2篇 |
2021年 | 1篇 |
2018年 | 5篇 |
2017年 | 3篇 |
2016年 | 6篇 |
2015年 | 3篇 |
2014年 | 1篇 |
2013年 | 2篇 |
2012年 | 18篇 |
2011年 | 31篇 |
2010年 | 7篇 |
2009年 | 3篇 |
2008年 | 22篇 |
2007年 | 13篇 |
2006年 | 13篇 |
2005年 | 15篇 |
2004年 | 16篇 |
2003年 | 17篇 |
2002年 | 11篇 |
2001年 | 2篇 |
2000年 | 2篇 |
1992年 | 1篇 |
1990年 | 1篇 |
排序方式: 共有196条查询结果,搜索用时 15 毫秒
31.
Astrid Wichmann Markus Kuhn Kay Hoeksema Ulrich Hoppe 《Cellular and molecular life sciences : CMLS》1992,48(1):1-3
Ethical principles and guidelines for scientific experiments on animals 相似文献
32.
Persistence of soil organic matter as an ecosystem property 总被引:65,自引:0,他引:65
Schmidt MW Torn MS Abiven S Dittmar T Guggenberger G Janssens IA Kleber M Kögel-Knabner I Lehmann J Manning DA Nannipieri P Rasse DP Weiner S Trumbore SE 《Nature》2011,478(7367):49-56
Globally, soil organic matter (SOM) contains more than three times as much carbon as either the atmosphere or terrestrial vegetation. Yet it remains largely unknown why some SOM persists for millennia whereas other SOM decomposes readily--and this limits our ability to predict how soils will respond to climate change. Recent analytical and experimental advances have demonstrated that molecular structure alone does not control SOM stability: in fact, environmental and biological controls predominate. Here we propose ways to include this understanding in a new generation of experiments and soil carbon models, thereby improving predictions of the SOM response to global warming. 相似文献
33.
34.
Anika M. Helferich Sarah J. Brockmann Jörg Reinders Dhruva Deshpande Karlheinz Holzmann David Brenner Peter M. Andersen Susanne Petri Dietmar R. Thal Jens Michaelis Markus Otto Steffen Just Albert C. Ludolph Karin M. Danzer Axel Freischmidt Jochen H. Weishaupt 《Cellular and molecular life sciences : CMLS》2018,75(23):4301-4319
35.
36.
37.
Chiow KH Tan Y Chua RY Huang D Ng ML Torta F Wenk MR Wong SH 《Cellular and molecular life sciences : CMLS》2012,69(9):1505-1521
Since being introduced globally as aspirin in 1899, acetylsalicylic acid has been widely used as an analgesic, anti-inflammation,
anti-pyretic, and anti-thrombotic drug for years. Aspirin had been reported to down-regulate surface expression of CD40, CD80,
CD86, and MHCII in myeloid dendritic cells (DC), which played essential roles in regulating the immune system. We hypothesized
that the down-regulation of these surface membrane proteins is partly due to the ability of aspirin in regulating trafficking/sorting
of endocytosed surface membrane proteins. By using an established epidermoid carcinoma cell line (A-431), which overexpresses
the epidermal growth factor receptor (EGFR) and transferrin receptor (TfnR), we show that aspirin (1) reduces cell surface
expression of EGFR and (2) accumulates endocytosed-EGFR and -TfnR in the early/sorting endosome (ESE). Further elucidation
of the mechanism suggests that aspirin enhances recruitment of SNX3 and SNX5 to membranes and consistently, both SNX3 and
SNX5 play essential roles in the aspirin-mediated accumulation of endocytosed-TfnR at the ESE. This study sheds light on how
aspirin may down-regulate surface expression of EGFR by inhibiting/delaying the exit of endocytosed-EGFR from the ESE and
recycling of endocytosed-EGFR back to the cell surface. 相似文献
38.
39.
Senderek J Krieger M Stendel C Bergmann C Moser M Breitbach-Faller N Rudnik-Schöneborn S Blaschek A Wolf NI Harting I North K Smith J Muntoni F Brockington M Quijano-Roy S Renault F Herrmann R Hendershot LM Schröder JM Lochmüller H Topaloglu H Voit T Weis J Ebinger F Zerres K 《Nature genetics》2005,37(12):1312-1314
SIL1 (also called BAP) acts as a nucleotide exchange factor for the Hsp70 chaperone BiP (also called GRP78), which is a key regulator of the main functions of the endoplasmic reticulum. We found nine distinct mutations that would disrupt the SIL1 protein in individuals with Marinesco-Sj?gren syndrome, an autosomal recessive cerebellar ataxia complicated by cataracts, developmental delay and myopathy. Identification of SIL1 mutations implicates Marinesco-Sj?gren syndrome as a disease of endoplasmic reticulum dysfunction and suggests a role for this organelle in multisystem disorders. 相似文献
40.
Patrick J. Shaw Bin Qu Markus Hoth Stefan Feske 《Cellular and molecular life sciences : CMLS》2013,70(15):2637-2656
Calcium (Ca2+) influx is required for the activation and function of all cells in the immune system. It is mediated mainly by store-operated Ca2+ entry (SOCE) through Ca2+ release-activated Ca2+ (CRAC) channels located in the plasma membrane. CRAC channels are composed of ORAI proteins that form the channel pore and are activated by stromal interaction molecules (STIM) 1 and 2. Located in the membrane of the endoplasmic reticulum, STIM1 and STIM2 have the dual function of sensing the intraluminal Ca2+ concentration in the ER and to activate CRAC channels. A decrease in the ER’s Ca2+ concentration induces STIM multimerization and translocation into puncta close to the plasma membrane where they bind to and activate ORAI channels. Since the identification of ORAI and STIM genes as the principal mediators of CRAC channel function, substantial advances have been achieved in understanding the molecular regulation and physiological role of CRAC channels in cells of the immune system and other organs. In this review, we discuss the mechanisms that regulate CRAC channel function and SOCE, the role of recently identified proteins and mechanisms that modulate the activation of ORAI/STIM proteins and the consequences of CRAC channel dysregulation for lymphocyte function and immunity. 相似文献