Amino-acid sequence of a Ca2+ + Mg2+-dependent ATPase from rabbit muscle sarcoplasmic reticulum, deduced from its complementary DNA sequence

We have cloned and sequenced complementary DNA encoding a Ca2+-ATPase of rabbit muscle sarcoplasmic reticulum. We propose a model of the protein which has 3 cytoplasmic domains joined to a set of 10 transmembrane helices by a narrow, penta-helical stalk. In this model, ATP bound to one cytoplasmic domain would phosphorylate an aspartate in an adjoining cytoplasmic domain, inducing translocation of Ca2+ from binding sites on the stalk.     

The minimal rank correlation,subject to order restrictions,with application to the weighted linear choice model

The weighted linear choice model is one of the most popular models in the social sciences. In this model the utility of a choice object is represented as a weighted sum of attribute-level desirabilities, where the weights are attribute importances. In many empirical contexts the choice objects are such that individuals are highly correlated in terms of their desirability ordering of levels within attribute (e.g., price levels, durability levels, etc.) but may differ appreciably in terms of their evaluations of each attribute's importance.In this paper we address the problem of how dissimilar two individuals may be, in a rank correlation sense, given that they agree completely on the desirability ordering of levels within attributes, but may disagree considerably regarding the importance they attach to the attributes themselves. The problem has interesting implications regarding the potential value of clustering individuals' utility functions for market segmentation or other such purposes.The authors would like to thank the editor and three anonymous reviewers for their excellent comments on an earlier draft of the paper.     

Generalized measures of association for ranked data with an application to prediction accuracy

A common practice in cross validation research in the behavioral sciences is to employ either the product moment correlation or a simple tabulation of first-choice “hits” for measuring the accuracy with which various preference models predict subjects’ responses to a holdout sample of choice objects. We propose a nonparametric approach for summarizing the accuracy of predicted rankings across a set of holdout-sample options. The methods that we develop contain a novel way to deal with ties and an approach to the different weighting of rank positions.     

Two new short-acting non-depolarizing neuromuscular blocking agents

Résumé Le chlorure de 1,1-octaméthylène et le méthylsulfate de 5,5-octaméthylènebis ont chez le chat un effet de blocage neuro-musculaire non dépolarisant, de courte durée. Les comparaisons faites avec des analogues voisins suggèrent que l'activité de ces composés est influencée par le degré d'empêchement stérique autour des atomes d'azote quaternaire. Les composés inhibent les acétylcholinestérases et s'opposent à des degrés divers aux effects muscariniques de l'acétylcholine.