全文获取类型
收费全文 | 143篇 |
免费 | 0篇 |
国内免费 | 1篇 |
专业分类
理论与方法论 | 2篇 |
现状及发展 | 29篇 |
研究方法 | 20篇 |
综合类 | 91篇 |
自然研究 | 2篇 |
出版年
2017年 | 1篇 |
2014年 | 1篇 |
2012年 | 4篇 |
2011年 | 8篇 |
2010年 | 4篇 |
2009年 | 5篇 |
2008年 | 9篇 |
2007年 | 4篇 |
2006年 | 5篇 |
2005年 | 5篇 |
2004年 | 8篇 |
2003年 | 5篇 |
2002年 | 4篇 |
2001年 | 8篇 |
2000年 | 9篇 |
1999年 | 3篇 |
1994年 | 2篇 |
1991年 | 1篇 |
1990年 | 2篇 |
1989年 | 3篇 |
1988年 | 1篇 |
1987年 | 3篇 |
1986年 | 2篇 |
1985年 | 1篇 |
1984年 | 4篇 |
1983年 | 1篇 |
1982年 | 3篇 |
1981年 | 1篇 |
1980年 | 4篇 |
1979年 | 7篇 |
1978年 | 2篇 |
1976年 | 4篇 |
1975年 | 3篇 |
1973年 | 2篇 |
1971年 | 5篇 |
1970年 | 2篇 |
1968年 | 1篇 |
1967年 | 3篇 |
1966年 | 2篇 |
1965年 | 2篇 |
排序方式: 共有144条查询结果,搜索用时 31 毫秒
131.
132.
Molecular model for elastin structure and function 总被引:2,自引:0,他引:2
133.
134.
Ali K Bilancio A Thomas M Pearce W Gilfillan AM Tkaczyk C Kuehn N Gray A Giddings J Peskett E Fox R Bruce I Walker C Sawyer C Okkenhaug K Finan P Vanhaesebroeck B 《Nature》2004,431(7011):1007-1011
Inflammatory substances released by mast cells induce and maintain the allergic response. Mast cell differentiation and activation are regulated, respectively, by stem cell factor (SCF; also known as Kit ligand) and by allergen in complex with allergen-specific immunoglobulin E (IgE). Activated SCF receptors and high-affinity receptors for IgE (FcvarepsilonRI) engage phosphoinositide 3-kinases (PI(3)Ks) to generate intracellular lipid second messenger signals. Here, we report that genetic or pharmacological inactivation of the p110delta isoform of PI(3)K in mast cells leads to defective SCF-mediated in vitro proliferation, adhesion and migration, and to impaired allergen-IgE-induced degranulation and cytokine release. Inactivation of p110delta protects mice against anaphylactic allergic responses. These results identify p110delta as a new target for therapeutic intervention in allergy and mast-cell-related pathologies. 相似文献
135.
Stephens P Hunter C Bignell G Edkins S Davies H Teague J Stevens C O'Meara S Smith R Parker A Barthorpe A Blow M Brackenbury L Butler A Clarke O Cole J Dicks E Dike A Drozd A Edwards K Forbes S Foster R Gray K Greenman C Halliday K Hills K Kosmidou V Lugg R Menzies A Perry J Petty R Raine K Ratford L Shepherd R Small A Stephens Y Tofts C Varian J West S Widaa S Yates A Brasseur F Cooper CS Flanagan AM Knowles M Leung SY Louis DN Looijenga LH Malkowicz B Pierotti MA Teh B Chenevix-Trench G 《Nature》2004,431(7008):525-526
The protein-kinase family is the most frequently mutated gene family found in human cancer and faulty kinase enzymes are being investigated as promising targets for the design of antitumour therapies. We have sequenced the gene encoding the transmembrane protein tyrosine kinase ERBB2 (also known as HER2 or Neu) from 120 primary lung tumours and identified 4% that have mutations within the kinase domain; in the adenocarcinoma subtype of lung cancer, 10% of cases had mutations. ERBB2 inhibitors, which have so far proved to be ineffective in treating lung cancer, should now be clinically re-evaluated in the specific subset of patients with lung cancer whose tumours carry ERBB2 mutations. 相似文献
136.
Chromosome aberrations in human solid tumors are hallmarks of gene deregulation and genome instability. This review summarizes current knowledge regarding aberrations, discusses their functional importance, suggests mechanisms by which aberrations may form during cancer progression and provides examples of clinical advances that have come from studies of chromosome aberrations. 相似文献
137.
138.
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells 总被引:44,自引:0,他引:44
A Ullrich L Coussens J S Hayflick T J Dull A Gray A W Tam J Lee Y Yarden T A Libermann J Schlessinger 《Nature》1984,309(5967):418-425
The complete 1,210-amino acid sequence of the human epidermal growth factor (EGF) receptor precursor, deduced from cDNA clones derived from placental and A431 carcinoma cells, reveals close similarity between the entire predicted v-erb-B mRNA oncogene product and the receptor transmembrane and cytoplasmic domains. A single transmembrane region of 23 amino acids separates the extracellular EGF binding and cytoplasmic domains. The receptor gene is amplified and apparently rearranged in A431 cells, generating a truncated 2.8-kilobase mRNA which encodes only the extracellular EGF binding domain. 相似文献
139.
140.