Control of cell growth: Rag GTPases in activation of TORC1

The target of rapamycin (TOR) is a central regulator controlling cell growth. TOR is highly conserved from yeast to mammals, and is deregulated in human cancers and diabetes. TOR complex 1 (TORC1) integrates signals from growth factors, cellular energy status, stress, and amino acids to control cell growth, mitochondrial metabolism, and lipid biosynthesis. The mechanisms of growth factors and cellular energy status in regulating TORC1 have been well established, whereas the mechanism by which amino acid induces TORC1 remains largely unknown. Recent studies revealed that Rag GTPases play a central role in the regulation of TORC1 activation in response to amino acids. In this review, we will discuss the recent progress in our understanding of Rag GTPase-regulated TORC1 activation in response to amino acids. Particular focus will be given to the function of Rag GTPases in TORC1 activation and how Rag GTPases are regulated by amino acids.     

一款超宽带陷波天线设计

为了很好地抑制5G通信系统(3.4～3.6 GHz)(中国电信:3.4～3.5 GHz;中国联通:3.5～3.6 GHz)对超宽带(Ultra-Wideband,UWB)系统的干扰,设计了一款超宽带陷波天线,超宽带陷波天线包括带有陷波缝隙辐射片、金属地板、介质板。先设计一款可以工作在超宽带频段的天线,然后在辐射片上采用陷波技术,即开U形缝隙,使得超宽带天线在3.4～3.6 GHz频段内实现陷波特性。仿真结果表明,该超宽带陷波天线方向图和增益特性良好,能够很好地抑制5G通信信号的干扰。     

高职生学业成就影响因素的实证研究

以浙江省5所高职院校《大学生心理健康教育》必修课的学生为研究对象,通过目标取向量表、学习策略量表、自我设限策略量表的调研,旨在探讨高职生成就目标取向、学习策略、自我设限及学业成就之间的关系.以研究结果为依据,提出以正确的成就目标为导向,减少自我设限行为,引导学生加强信息处理和元认知策略使用的实施途径.     

水平循环荷载引起的砂土沉陷-致密作用对刚性桩承载力的影响分析

为研究砂土中刚性桩基础在循环荷载作用下的承载力演化规律,提出了一种循环后单桩承载力的评估方法.首先,基于沉陷坑与致密区域土体的质量守恒原理,量化了由沉陷引起的土体参数变化;然后,根据API规范中的砂土水平土抗力-位移模型计算循环前后的单桩承载力;最后,提出了循环后单桩承载力的评估模型,并对沉陷坑尺寸、土体初始相对密实度和致密区域模式等因素进行对比分析.结果 表明:单桩承载力随沉陷坑的发展不断增大;对于松砂、中密砂和密砂,循环后的单桩承载力可分别提高约3.0、1.5、1.2倍,提高幅值随相对密实度的增大而降低;2种土体变形模式中,单锥模式相比于双锥模式更符合真实的致密区域形态.     

Secure Two-Party Distance Computation Protocol Based on Privacy Homomorphism and Scalar Product in Wireless Sensor Networks

Numerous privacy-preserving issues have emerged along with the fast development of the Internet of Things. In addressing privacy protection problems in Wireless Sensor Networks(WSN), secure multi-party computation is considered vital, where obtaining the Euclidian distance between two nodes with no disclosure of either side’s secrets has become the focus of location-privacy-related applications. This paper proposes a novel Privacy-Preserving Scalar Product Protocol(PPSPP) for wireless sensor networks. Based on PPSPP, we then propose a Homomorphic-Encryption-based Euclidean Distance Protocol(HEEDP) without third parties. This protocol can achieve secure distance computation between two sensor nodes. Correctness proofs of PPSPP and HEEDP are provided, followed by security validation and analysis. Performance evaluations via comparisons among similar protocols demonstrate that HEEDP is superior; it is most efficient in terms of both communication and computation on a wide range of data types, especially in wireless sensor networks.     

GLP-1R agonists therapy for type 2 diabetes

Glucagon-like peptide-1 receptor （GLP-1R） agonists are widely used for treating type 2 diabetes mellitus （T2DM） be- cause of their glucose-lowering and weight-losing effects, and low risk of hypoglycemia. Hence, there is considerable interest in understanding the mechanism underlying the beneficial effects of GLP-I and developing stable and effective GLP-1R agonists. Here, we summarize the presently known mechanism of GLP-I actions, which are mainly through regulating cAMP-PKA signaling pathway; the latest developments in novel clinical GLP-1R agonists are also introduced, which are characterized with multiple properties, such as extended half-life, reduced side-effects, lower production costs and more convenient drug dosing mode. The potential risk of GLP-I-based therapeutics, an often-ignored fact, is also discussed.     

高校图书馆开展讲座的调查与分析--以广州体育学院图书馆为例

在对广州体育学院图书馆进行读者调查的基础上，提出了高校图书馆进一步开展好讲座的对策，包括加大宣传力度、拓宽服务领域、维护文明秩序和建立健全讲座制度等。     

科学饮食 营造健康生活

饮食是人类生存的根本,是生命的源泉。伴随着人民生活水平的提高和对餐饮业需求的增长,饮食健康成了一道靓丽的风景。饮食文化、合理膳食、科学烹调和饮食习惯引起了人们广泛关注。     

地方高校“播音与主持艺术专业热”透视

新世纪以来,伴随着“艺考”的升温,中国高等教育出现了前所未有的“播音与主持艺术专业热”.具体表现在开设高校增多、报考学生数量庞大、专业规模迅速膨胀和专业培训红火等方面.专业门槛相对较低、专业收费相对较高、传媒业的迅猛发展、播音与主持人的明星效应等是导致“播音与主持艺术专业热”的主要原因.只有政府、学校、家长、学生共同面对,才能使“播音与主持艺术专业热”降温,从而回归正常轨道.     

地板上尿渍足迹的溴酚蓝溶液新型增强技术研究

目的探索一种新型地板表面尿渍足迹的溴酚蓝酒精溶液增强技术。方法使用BRWY-1雾化器对75%酒精溴酚蓝酒精溶液对地板表面上不同遗留时间和遗留量的尿渍足迹进行溴酚蓝增强处理。结果使用BRWY-1雾化器对75%酒精溴酚蓝溶液雾化喷涂,能够有效增强地板表面上的尿渍足迹,时间约为30 s,尿渍足迹纹线颜色为蓝色,特征清晰连贯、与地板反差明显。结论 BRWY-1雾化器雾化75%酒精溴酚蓝溶液能够有效增强地板表面与尿渍足迹的反差,可作为一种新型尿渍足迹显现和增强技术,有效提高该类痕迹的发现率、提取率和利用率。