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981.
Saleh M Vaillancourt JP Graham RK Huyck M Srinivasula SM Alnemri ES Steinberg MH Nolan V Baldwin CT Hotchkiss RS Buchman TG Zehnbauer BA Hayden MR Farrer LA Roy S Nicholson DW 《Nature》2004,429(6987):75-79
Caspases mediate essential key proteolytic events in inflammatory cascades and the apoptotic cell death pathway. Human caspases functionally segregate into two distinct subfamilies: those involved in cytokine maturation (caspase-1, -4 and -5) and those involved in cellular apoptosis (caspase-2, -3, -6, -7, -8, -9 and -10). Although caspase-12 is phylogenetically related to the cytokine maturation caspases, in mice it has been proposed as a mediator of apoptosis induced by endoplasmic reticulum stress including amyloid-beta cytotoxicity, suggesting that it might contribute to the pathogenesis of Alzheimer's disease. Here we show that a single nucleotide polymorphism in caspase-12 in humans results in the synthesis of either a truncated protein (Csp12-S) or a full-length caspase proenzyme (Csp12-L). The read-through single nucleotide polymorphism encoding Csp12-L is confined to populations of African descent and confers hypo-responsiveness to lipopolysaccharide-stimulated cytokine production in ex vivo whole blood, but has no significant effect on apoptotic sensitivity. In a preliminary study, we find that the frequency of the Csp12-L allele is increased in African American individuals with severe sepsis. Thus, Csp12-L attenuates the inflammatory and innate immune response to endotoxins and in doing so may constitute a risk factor for developing sepsis. 相似文献
982.
983.
Jaffe W Meisenheimer K Röttgering HJ Leinert Ch Richichi A Chesneau O Fraix-Burnet D Glazenborg-Kluttig A Granato GL Graser U Heijligers B Köhler R Malbet F Miley GK Paresce F Pel JW Perrin G Przygodda F Schoeller M Sol H Waters LB Weigelt G Woillez J De Zeeuw PT 《Nature》2004,429(6987):47-49
Active galactic nuclei (AGNs) display many energetic phenomena--broad emission lines, X-rays, relativistic jets, radio lobes--originating from matter falling onto a supermassive black hole. It is widely accepted that orientation effects play a major role in explaining the observational appearance of AGNs. Seen from certain directions, circum-nuclear dust clouds would block our view of the central powerhouse. Indirect evidence suggests that the dust clouds form a parsec-sized torus-shaped distribution. This explanation, however, remains unproved, as even the largest telescopes have not been able to resolve the dust structures. Here we report interferometric mid-infrared observations that spatially resolve these structures in the galaxy NGC 1068. The observations reveal warm (320 K) dust in a structure 2.1 parsec thick and 3.4 parsec in diameter, surrounding a smaller hot structure. As such a configuration of dust clouds would collapse in a time much shorter than the active phase of the AGN, this observation requires a continual input of kinetic energy to the cloud system from a source coexistent with the AGN. 相似文献
984.
The Madagascan fat-tailed dwarf lemur, Cheirogaleus medius, hibernates in tree holes for seven months of the year, even though winter temperatures rise to over 30 degrees C. Here we show that this tropical primate relies on a flexible thermal response that depends on the properties of its tree hole: if the hole is poorly insulated, body temperature fluctuates widely, passively following the ambient temperature; if well insulated, body temperature stays fairly constant and the animal undergoes regular spells of arousal. Our findings indicate that arousals are determined by maximum body temperatures and that hypometabolism in hibernating animals is not necessarily coupled to a low body temperature. 相似文献
985.
QU Yuangao XIE Guwei & GONG Yiming . Faculty of Earth Sciences China University of Geosciences Wuhan China . Nanjing Institute of Geology Paleontology Chinese Academy of Sciences Nanjing China 《科学通报(英文版)》2004,49(21):2288-2295
Stromatolitesareusuallyinterpretedastheorgano-sedimentarystructurescausedbythegrowthandmetabo-lismofmicro-organisms,principallycyanobacteriaandprecipitatedmineralgrainstrappedtothestickylay-ers[1—5].Asthesunlightisstrongindaytime,thealgaefila-mentsshowstrongactivityinphotosynthesisandgrowtowardsunlight.Ontheotherhand,asthesunlightisweakatnight,thealgaefilamentsshowinactivityinphotosyn-thesisandgrowhorizontally.Duringthecourseofgrowth,thealgaewillproducesomeglutinoussecretionwhichcancatchsedim… 相似文献
986.
浅谈如何做好高校图书馆的思想政治工作 总被引:1,自引:0,他引:1
总结、分析了当前高校图书馆思想政治工作所存在的主要问题,提出了进一步加强政治思想工作的思路,即针对图书馆思想政治工作的特点和要求,围绕“读者第一”这个中心,建立健全管理机制,突出图书馆的教育职能,加强精神文明的建设。 相似文献
987.
GongZhu-qian ZhuGuo-qiang 《武汉大学学报:自然科学英文版》2004,9(3):319-322
In this paper, a two-dimensional (2-D) finitedifference time-domain method (FDTD) scheme is used to simulate the transient scattering characteristics of buried objects, which are modeled by columns of arbitrary permittivities, conductivities, and sizes. The FDTD soil is modeled by isotropic, homogeneous and lossy media. The standing-traveling wave boundary condition (STWBC) that can simplify calculation and save CPU storage is used for modeling physical absorbers inside the FDTD computational dornairL Reflection of electromagnetic pulses incident on a layered medium and transient scattering by the ground and an underground airsqu are cylinder are computed. These results verify the validity of the FDTD scheme by comparisons with those shown in some references. Numerical results presented in the final part of this paper are desirable and meaningful, explicitly distinguishing echo waves stemming from the ground and the buried ohjects. 相似文献
988.
WUShi-jing GONGZhi-bo YINYong HUANGHe-chao LOUWei-hua 《武汉大学学报:自然科学英文版》2004,9(5):839-844
Making use of Microsoft Visual Studio. NET platform, hierarchical network planning is realized in working procedure time-optimization of the construction by TBM. and hierarchical network graph of the construction by TBM is drawn based on browser. Then the theory of system realization is discussed, six components of system that can be reused are explained emphatically. The realization of hierarchical network panning in Internet provides available guarantee for controlling rate of progress in large-scale or middle-sized projects. 相似文献
989.
Resumé Le développement embryonnaire du termiteKalotermes flavicollis dure 54 jours à une température de 26°C. Le germe appartient au «type court» (Kurzkeimtyp) selon la classification deKrause
2, mais se distingue de celui-ci par le fait qu'avant la blastocinèse il ne s'enfonce pas dans le vitellus, mais reste en position superficielle. A partir du 31e jour, il effectue d'importants déplacements (voir Fig. 2) qui mènent vers le 35e jour à son orientation définitive dans l'uf. 相似文献
990.
Zusammenfassung Elektronenmikroskopische Untersuchungen der Granulocyten anthropoider Affen ergaben Unterschiede in der Struktur der eosinophilen Granula und eine bisher unbekannte fibrilläre Granulationsform in Orangutan Neutrophilen.
These studies were supported by U.S. Public Health Service Grant No. FR 00165 from the National Institutes of Health and Atomic Energy Commission grant No. AT (30-1) 3808. 相似文献
These studies were supported by U.S. Public Health Service Grant No. FR 00165 from the National Institutes of Health and Atomic Energy Commission grant No. AT (30-1) 3808. 相似文献