Genome-wide association analysis identifies three psoriasis susceptibility loci

We carried out a meta-analysis of two recent psoriasis genome-wide association studies with a combined discovery sample of 1,831 affected individuals (cases) and 2,546 controls. One hundred and two loci selected based on P value rankings were followed up in a three-stage replication study including 4,064 cases and 4,685 controls from Michigan, Toronto, Newfoundland and Germany. In the combined meta-analysis, we identified three new susceptibility loci, including one at NOS2 (rs4795067, combined P = 4 × 10?11), one at FBXL19 (rs10782001, combined P = 9 × 10?1?) and one near PSMA6-NFKBIA (rs12586317, combined P = 2 × 10??). All three loci were also associated with psoriatic arthritis (rs4795067, combined P = 1 × 10??; rs10782001, combined P = 4 × 10??; and rs12586317, combined P = 6 × 1??) and purely cutaneous psoriasis (rs4795067, combined P = 1 × 10??; rs10782001, combined P = 2 × 10??; and rs12586317, combined P = 1 × 10??). We also replicated a recently identified association signal near RNF114 (rs495337, combined P = 2 × 10??).     

新疆甜菜上两个病毒分离物的研究

在新疆甜菜的根部和叶片分离到两种病毒分离物。回接到甜菜上均产生环斑和沿脉线纹。最后形成坏死斑。病毒粒体为20面体,平均直径28nm。除侵染甜菜外还侵染苋色藜,昆诺阿藜、番杏、菠菜等,引起局部坏死斑,在普通烟、心叶烟、菜豆、黄瓜、番茄上无症状侵染,病毒致死温度为70℃,10分钟,体外存活期13天以上,冻干病叶三年后仍有侵染力。通过PEG沉淀。差速离心,琼脂糖柱层折及蔗糖梯度离心,可得到较高浓度的纯化病毒,病毒的紫外吸收最低值在245nm,最高值在260nm。病毒外壳蛋白的分子量为54000道尔顿,病毒基因组核酸为两个组份。在琼脂双扩散实验中,能与番茄黑环病毒(TBRV)抗血清产生较弱的沉淀线,与黄瓜花叶病毒(CMV),烟草坏死病毒(TMV)。烟草环斑病毒(TRSV)不发生反应,从上述结果可以初步认为这两种分离物为番茄黑环病毒侵染甜菜的一个株系。     

量子系统科学的重要分支:量子控制论

本文针对量子通信和量子计算等量子信息学的发展趋势,全面阐述量子系统科学的重要研究方向——以研究微观世界系统量子态的控制问题的新兴边缘学科--量子控制论.文中先从量子信息论引出量子控制论,进而对量子控制的定义、特点、研究现状、研究内容进行了系统的阐述,并提出了一些新的研究思路。     

一种基于改进ASM的运动目标跟踪方法

ASM是一种应用于非刚体轮廓匹配的统计模型方法,由于匹配结果的可靠性依赖于先验的灰度模型,导致灰度信息发生动态变化时基于ASM的目标跟踪效果不佳.针对跟踪中轮廓匹配的鲁棒性问题,提出了一种基于改进ASM的目标跟踪方法,该方法采用一种在线提取和更新灰度模型的机制,摆脱对目标先验灰度的依赖;并结合强边缘特征和目标内部灰度信息,改进传统ASM方法的灰度模型和搜索算法,提高了运动过程中目标附近背景信息变化情况下轮廓匹配的鲁棒性和快速性;跟踪过程中利用卡尔曼滤波预测目标位置提高了运行效率.实验验证了方法的有效性和鲁棒性.     

Pattern recognition of quantum information based on patterndistance

1.INTRODUCTION In1980s’,thequantuminformationtheoryhas rapidlydevelopedbecauseoftheclosecombinationof quantumtheoryandinformationscience.Quantum informationhasmanyadvantagesoverclassicalinfor mation.Forexample,quantumcommunicationcan providemoresecurequantumcryptography[1]and quantumcomputationcanspeedupsolvingsome mathematicalproblems[2].Theseadvantagesarede rivedfromsomespecialquantumcharacteristics,such asuncertainty,quantumcoherenceandquantumen tanglement[3].Itistheseadvantagesthatma…     

Grey systems for intelligent sensors and information processing

In a measurement system,new representation methods are necessary to maintain the uncertainty and to supply more powerful ability for reasoning and transformation between numerical system and symbolic system.A grey measurement system is discussed from the point of view of intelligent sensors and incomplete information processing compared with a numerical and symbolized mea8urement system.The methods of grey representation and information processing are proposed for data collection and reasoning.As a case study,multi-ultrasonic sensor systems are demonstrated to verify the effectiveness of the proposed methods.     

Merlin--rapid analysis of dense genetic maps using sparse gene flow trees.

Efforts to find disease genes using high-density single-nucleotide polymorphism (SNP) maps will produce data sets that exceed the limitations of current computational tools. Here we describe a new, efficient method for the analysis of dense genetic maps in pedigree data that provides extremely fast solutions to common problems such as allele-sharing analyses and haplotyping. We show that sparse binary trees represent patterns of gene flow in general pedigrees in a parsimonious manner, and derive a family of related algorithms for pedigree traversal. With these trees, exact likelihood calculations can be carried out efficiently for single markers or for multiple linked markers. Using an approximate multipoint calculation that ignores the unlikely possibility of a large number of recombinants further improves speed and provides accurate solutions in dense maps with thousands of markers. Our multipoint engine for rapid likelihood inference (Merlin) is a computer program that uses sparse inheritance trees for pedigree analysis; it performs rapid haplotyping, genotype error detection and affected pair linkage analyses and can handle more markers than other pedigree analysis packages.     

西藏札达、噶尔地区侏罗—白垩纪双壳类化石新材料

文章描述了西藏最西南部札达、噶尔地区双壳类化石2新种和1新亚种,并刊出部分双壳类化石图版。