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91.
Summary After injection of microspheres into both renal arteries of rats, an irreversible shock syndrome develops, resulting in death within 4–12 h. Ligation of both renal pedicles after injection of microspheres prevents the shock. It is presumed that kininogenases released from the kidneys participate in the pathogenesis of the shock syndrome.These studies were supported in part by the Deutsche Forschungsgemeinschaft within the SFB 90, Cardiovasculäres System. 相似文献
92.
H. -J. Hess J. S. Bindra J. W. Constantine W. Elger O. Loge E. Schillinger W. Losert 《Cellular and molecular life sciences : CMLS》1977,33(8):1076-1077
Summary N-methanesulfonyl 16-phenoxy--tetranor PGE2 is a prostaglandin analog which is markedly more tissue selective than PGE2. This compound is 10–30 times more potent than PGE2 in animal models which are considered relevant to antifertility effects in humans. In pharmacological tests which are believed to be predictive for side effects in humans, the compound has potency either equal to or less than that of PGE2. 相似文献
93.
94.
Budiansky S 《Nature》1983,301(5896):101
Joseph Cort, a researcher at Mount Sinai Medical School in New York City from 1976 to 1980, has admitted fabricating data on the synthesis of hormone analogues. Cort's research at Mount Sinai was supported principally by a contract from Vega Biochemicals, though he received a small amount of support under a National Institutes of Health grant to his department. 相似文献
95.
Budiansky S 《Nature》1983,304(5927):572
The Environmental Protection Agency is asserting regulatory control over the commercial production of genetically-engineered microorganisms, such as oil-eating bacteria, intended for release into the environment. EPA's legally-complex claim that such organisms are "new chemical substances," and thus subject to the Toxic Substances Control Act (TSCA), raises a challenge to the adequacy of regulation by the National Institute of Health's Recombinant DNA Advisory Committee (RAC) over the commercial and ecological implications of environmental release. Industry, which has been voluntarily adhering to the RAC guidelines, is reluctant to challenge application of the relatively lenient TSCA requirements but eager to see the legal uncertainties resolved. 相似文献
96.
G. D. Ledney H. M. Gelston Jr S. R. Weinberg E. D. Exum 《Cellular and molecular life sciences : CMLS》1982,38(10):1228-1230
Summary Wound trauma-induced survival from radiation may be related to increased mitosis in hematopoietic cells. This is supported by the cell cycle-dependent drug hydroxyurea, which 1. blocked survival of wounded mice injected 2 or 3 days after 900 rad and 2. reduced the number of endogenous CFU-s in wounded mice injected shortly before 700 rad.Supported by the Armed Forces Radiobiology Research Institute, Defense Nuclear Agency, under Research Work Unit MJ00018. Views presented in this paper are those of the authors; no endorsement by the Defense Nuclear Agency has been given or should be inferred.Research was conducted according to the principles enunciated in the Guide for the Care and Use of Laboratory Animals prepared by the Institute of Laboratory Research, National Research Council. 相似文献
97.
G. Zamboni E. Perez P. L. Parmeggiani 《Cellular and molecular life sciences : CMLS》1982,38(10):1188-1189
Summary In rats adapted to a 1212 h light-dark (LD) schedule, cyclic AMP concentration in the preoptic region showed a L minimum and D maximum. No significant fluctuations were observed in the parietal cortex.Supported by grant No. 79.01946.04 awarded by the National Research Council (CNR), Rome, Italy. 相似文献
98.
Captopril (SQ 14,225): In vitro and in vivo influence on the proliferative response of rat lymphocytes 总被引:1,自引:0,他引:1
Lise Binderup E. Bramm E. Arrigoni-Martelli 《Cellular and molecular life sciences : CMLS》1982,38(3):399-401
Summary Captopril in vitro (50–500 g/ml) increased3H-TdR incorporation in unstimulated and mitogen-stimulated cultures of rat lymphocytes. Unseparated spleen and lymph node cells of rats orally treated with captopril (50 mg/kg/day×4) showed decreased basal and mitogen stimulated3H-TdR incorporation. The removal of macrophages abrogated this inhibitory effect. Leucine aminopeptidase activity of macrophages was reduced — in vivo and in vitro — by captopril.Acknowledgments. The authors thank the Squibb Institute for Medical Research for the gift of Captopril. The excellent technical assistance of Ms B. Hasselriis, Ms B. Rumler and Ms E. Greve Petersen is gratefully acknowledged. 相似文献
99.
Summary The defense secretion of soldiers ofReticulitermes lucifugus has been shown to contain, predominantly, (R)-(–)-(E,E)-geranyllinalool together with germacrene A and -farnesene.This report covers part of a collaborative study with J.-L. Clément, Lab. d'Evolution, Université P. et M. Curie, Paris, to whom we are grateful for supplies of material and discussions. We also thank Dr O.T. Jones for collections ofReticulitermes lucifugus. 相似文献
100.
Budiansky S 《Nature》1982,300(5888):95-96
An attorney for Stanford and the University of California has conceded that there is a serious error in the second Cohen-Boyer genetic engineering patent, but he argues that the patent is still valid. In an August decision to reject the patent, the U.S. Patent Office cited the error as one of several potential flaws. The same potential flaws are found in the original Cohen-Boyer patent, as well. Also in question is whether Robert Helling of the University of Michigan should be included as a co-inventor. Further appeals could delay a final decision until the summer of 1984 or beyond. 相似文献