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181.
LEONARD Michel 《中山大学学报(自然科学版)》2007,46(Z2):126-129
The science of services constitutes a breakthrough in the traditional way of thinking of the place of informatics in the economic development of a State,a Region,an enterprise and consequently in the teaching programs.The question is no more only a question of computer science.We are in front of a more complex situation,which requires not only a multidisciplinary approach,but an interoperable approach at the intellectual level.This paper is an introduction to this complexity and it is also an attempt to propose crucial questions about the new bachelor programs and master programs. 相似文献
182.
本书是法国埃库勒理工学院一套著名的教科书中的一本.是作者为高年级大学生讲授原子核物理相关的一些专题课发展而成的教材。作者们认为大多数核现象都可以从基于泡利原理与库仑势垒的一些简单的论证理解。因此本书并不打算对于核理论现代发展深人讨论,而是把重点放在核物理学各方面的实际应用。本书充分利用了从网上可以得到的大量核物理的实验数据资源。 相似文献
183.
Platelet shape change and aggregation 总被引:1,自引:0,他引:1
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185.
Summary A combined treatment involving a radio-sensitizing chemical and low doses of X-rays was investigated. Small quantities of iodoacetamide can cause an increase in the radiation damages of rat embryos. The possibility of inhibition of postirradiation repair mechanisms is discussed. 相似文献
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187.
Ramiro AR Jankovic M Callen E Difilippantonio S Chen HT McBride KM Eisenreich TR Chen J Dickins RA Lowe SW Nussenzweig A Nussenzweig MC 《Nature》2006,440(7080):105-109
Chromosomal translocations involving the immunoglobulin switch region are a hallmark feature of B-cell malignancies. However, little is known about the molecular mechanism by which primary B cells acquire or guard against these lesions. Here we find that translocations between c-myc and the IgH locus (Igh) are induced in primary B cells within hours of expression of the catalytically active form of activation-induced cytidine deaminase (AID), an enzyme that deaminates cytosine to produce uracil in DNA. Translocation also requires uracil DNA glycosylase (UNG), which removes uracil from DNA to create abasic sites that are then processed to double-strand breaks. The pathway that mediates aberrant joining of c-myc and Igh differs from intrachromosomal repair during immunoglobulin class switch recombination in that it does not require histone H2AX, p53 binding protein 1 (53BP1) or the non-homologous end-joining protein Ku80. In addition, translocations are inhibited by the tumour suppressors ATM, Nbs1, p19 (Arf) and p53, which is consistent with activation of DNA damage- and oncogenic stress-induced checkpoints during physiological class switching. Finally, we demonstrate that accumulation of AID-dependent, IgH-associated chromosomal lesions is not sufficient to enhance c-myc-Igh translocations. Our findings reveal a pathway for surveillance and protection against AID-dependent DNA damage, leading to chromosomal translocations. 相似文献
188.
Pouchard M 《Nature》2006,442(7105):878-879
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Biodiversity loss and its impact on humanity 总被引:10,自引:0,他引:10
Cardinale BJ Duffy JE Gonzalez A Hooper DU Perrings C Venail P Narwani A Mace GM Tilman D Wardle DA Kinzig AP Daily GC Loreau M Grace JB Larigauderie A Srivastava DS Naeem S 《Nature》2012,486(7401):59-67
The most unique feature of Earth is the existence of life, and the most extraordinary feature of life is its diversity. Approximately 9 million types of plants, animals, protists and fungi inhabit the Earth. So, too, do 7 billion people. Two decades ago, at the first Earth Summit, the vast majority of the world's nations declared that human actions were dismantling the Earth's ecosystems, eliminating genes, species and biological traits at an alarming rate. This observation led to the question of how such loss of biological diversity will alter the functioning of ecosystems and their ability to provide society with the goods and services needed to prosper. 相似文献