全文获取类型
收费全文 | 136篇 |
免费 | 0篇 |
国内免费 | 1篇 |
专业分类
丛书文集 | 2篇 |
理论与方法论 | 1篇 |
现状及发展 | 43篇 |
研究方法 | 3篇 |
综合类 | 86篇 |
自然研究 | 2篇 |
出版年
2022年 | 1篇 |
2016年 | 2篇 |
2015年 | 1篇 |
2014年 | 4篇 |
2012年 | 1篇 |
2011年 | 6篇 |
2010年 | 1篇 |
2009年 | 5篇 |
2008年 | 4篇 |
2007年 | 6篇 |
2006年 | 3篇 |
2005年 | 5篇 |
2004年 | 5篇 |
2003年 | 2篇 |
2002年 | 4篇 |
2001年 | 3篇 |
2000年 | 8篇 |
1999年 | 1篇 |
1992年 | 3篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1988年 | 1篇 |
1987年 | 2篇 |
1986年 | 1篇 |
1985年 | 3篇 |
1984年 | 5篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1979年 | 2篇 |
1978年 | 3篇 |
1977年 | 4篇 |
1976年 | 3篇 |
1975年 | 1篇 |
1974年 | 1篇 |
1973年 | 5篇 |
1972年 | 2篇 |
1971年 | 7篇 |
1970年 | 5篇 |
1969年 | 5篇 |
1968年 | 7篇 |
1967年 | 7篇 |
1966年 | 2篇 |
1962年 | 1篇 |
1954年 | 1篇 |
排序方式: 共有137条查询结果,搜索用时 15 毫秒
41.
42.
M. Adinolfi B. Gardner F. Giannelli M. McGuire 《Cellular and molecular life sciences : CMLS》1967,23(4):271-272
Zusammenfassung Es konnte gezeigt werden, dass sich menschliche periphere Lymphozyten, mit Antikörper gegen die H-Ketten des-Globulins behandelt, in Lymphoblasten umwandeln lassen und dass sie in vitro DNA synthetisieren. 相似文献
43.
F. Quagliata Philippa M. Sanders D. L. Gardner 《Cellular and molecular life sciences : CMLS》1968,24(10):1028-1029
Résumé Un nouveau composé anthracyclique à propriétés antibiotiques et cytotoxiques, la Rubidomycine (Daunomycine), a été administré à des rats peu après injection intra-dermique d'adjuvant complet de Freund. Par comparaison avec un groupe témoin qui a été traité avec un autre antibiotique, la tétracycline, non réputé cytotoxique, on a constaté une réduction marquée des lésions systémiques et de l'arthrite de la maladie provoquée par l'adjuvant.
Work conducted during the tenure of a Nuffield Research Fellowship.
Junior Fellow, Medical Research Council. 相似文献
Work conducted during the tenure of a Nuffield Research Fellowship.
Junior Fellow, Medical Research Council. 相似文献
44.
45.
46.
Conductances of single ion channels opened by nicotinic agonists are indistinguishable 总被引:1,自引:0,他引:1
Hypotheses concerning the mechanism by which acetylcholine-like agonists cause ion channels to open often suppose that the receptor-ionophore complex can exist in either of two discrete conformations, open and shut. On the basis of noise analysis it has been reported that certain agonists open ion channels of lower conductance than usual, though many potent agonists give similar conductances, and hence that differences in the conductance of ion channels opened by different agonists may contribute to differences in efficacy. Here we have reinvestigated this question by recording single ion channel currents evoked by acetylcholine-like agonists on embryonic rat muscle in tissue culture and on adult frog muscle endplate. Ten different agonists (Fig. 1) were tested, including several that noise analysis has suggested have a low conductance. The single-channel conductance was found to be the same, within a few per cent, for all 10 agonists. It seems that noise analysis has given erroneously low conductances in some cases. Therefore efficacy differences do not depend on differences in single-channel conductance evoked by various agonists but presumably on the position of the open-shunt equilibrium of the agonist-channel complexes. 相似文献
47.
C. R. Gardner E. A. Robson C. Stanford 《Cellular and molecular life sciences : CMLS》1978,34(12):1577-1578
Summary Preliminary observations of formaldehyde-induced fluorescence support the suggestion that monoamines such as noradrenaline, dopamine and 5-hydroxytryptamine are transmitter agents in the central nervous system of Onychophora.Acknowledgments. We wish to thank Dr M. Fillenz for valuable advice and for generously enabling this work to be carried out, and we are indebted to Dr V. van der Lande for material. 相似文献
48.
Summary Preparations of longitudinal muscle respond to catecholamines if the ventral nerve cords are present, and also to 5-hydroxytryptamine. The response to 5HT is complex if the central nervous system is present, but muscle alone is probably inhibited.Acknowledgments. It is a pleasure to thank Professor A.C. Brown for providing facilities in the Zoology Department, University of Cape Town, and Mr L.R. Alexander and his colleagues for help in obtaining materials. 相似文献
49.
Carlton JM Adams JH Silva JC Bidwell SL Lorenzi H Caler E Crabtree J Angiuoli SV Merino EF Amedeo P Cheng Q Coulson RM Crabb BS Del Portillo HA Essien K Feldblyum TV Fernandez-Becerra C Gilson PR Gueye AH Guo X Kang'a S Kooij TW Korsinczky M Meyer EV Nene V Paulsen I White O Ralph SA Ren Q Sargeant TJ Salzberg SL Stoeckert CJ Sullivan SA Yamamoto MM Hoffman SL Wortman JR Gardner MJ Galinski MR Barnwell JW Fraser-Liggett CM 《Nature》2008,455(7214):757-763
The human malaria parasite Plasmodium vivax is responsible for 25-40% of the approximately 515 million annual cases of malaria worldwide. Although seldom fatal, the parasite elicits severe and incapacitating clinical symptoms and often causes relapses months after a primary infection has cleared. Despite its importance as a major human pathogen, P. vivax is little studied because it cannot be propagated continuously in the laboratory except in non-human primates. We sequenced the genome of P. vivax to shed light on its distinctive biological features, and as a means to drive development of new drugs and vaccines. Here we describe the synteny and isochore structure of P. vivax chromosomes, and show that the parasite resembles other malaria parasites in gene content and metabolic potential, but possesses novel gene families and potential alternative invasion pathways not recognized previously. Completion of the P. vivax genome provides the scientific community with a valuable resource that can be used to advance investigation into this neglected species. 相似文献
50.
New cell lines from mouse epiblast share defining features with human embryonic stem cells 总被引:3,自引:0,他引:3
Tesar PJ Chenoweth JG Brook FA Davies TJ Evans EP Mack DL Gardner RL McKay RD 《Nature》2007,448(7150):196-199