证券投资组合的解析算法

给出了证券组合模型, 在其使对称矩阵与对角矩阵合同的可逆阵的一般规律基础上, 推导出证券投资组合给合权数的解析表达式, 并给出实例验证.     

取送货混排的车辆路径问题的模糊动态研究

通过增加车辆预留能力系数,保证在避免货物重新排列的情况下完成取送货.充分考虑物流运输行业的现状,重点研究相关参数模糊且各取货节点动态随机出现的问题.在求解方法上,首先为车辆路线中每一个节点、车辆以及相邻节点间的路径建立标签,并建立初始路径;其次,通过标签插入方法求解模糊动态问题;最后给出了方案应用失败后的处理方法.仿真实例验证了所提方法的有效性.     

Mutations in NMNAT1 cause Leber congenital amaurosis and identify a new disease pathway for retinal degeneration

Leber congenital amaurosis (LCA) is a blinding retinal disease that presents within the first year after birth. Using exome sequencing, we identified mutations in the nicotinamide adenine dinucleotide (NAD) synthase gene NMNAT1 encoding nicotinamide mononucleotide adenylyltransferase 1 in eight families with LCA, including the family in which LCA was originally linked to the LCA9 locus. Notably, all individuals with NMNAT1 mutations also have macular colobomas, which are severe degenerative entities of the central retina (fovea) devoid of tissue and photoreceptors. Functional assays of the proteins encoded by the mutant alleles identified in our study showed that the mutations reduce the enzymatic activity of NMNAT1 in NAD biosynthesis and affect protein folding. Of note, recent characterization of the slow Wallerian degeneration (Wld(s)) mouse model, in which prolonged axonal survival after injury is observed, identified NMNAT1 as a neuroprotective protein when ectopically expressed. Our findings identify a new disease mechanism underlying LCA and provide the first link between endogenous NMNAT1 dysfunction and a human nervous system disorder.     

多通道SAR-GMTI二维间歇采样延时转发干扰

为充分降低合成孔径雷达地面动目标显示(synthetic aperture radar-ground moving target indication, SAR-GMTI)对地面重要运动目标的威胁,本文在SAR间歇采样转发干扰技术基础上,针对多通道SAR-GMTI提出了二维间歇采样慢时间延时转发干扰方法。该方法利用二维间歇采样实现干扰信号的二维频谱周期性拓展,从而生成无法被SAR-GMTI完全对消的假目标群,并进一步提出采用慢时间延时转发来实现对假目标群方位向位移的控制。在此基础上,针对SAR-GMTI的对消特性给出了多组延时转发干扰应用模型。理论分析和仿真实验表明:该方法可对多通道SAR-GMTI产生二维假目标群,且假目标幅度受正弦调制函数的影响出现增强和削弱,多组延时转发干扰方法可以实现增强区与削弱区互补,从而形成分布更密集、覆盖范围更广的二维多假目标干扰效果。     

Forecasting for the LCD monitor market

The TFT‐LCD (thin‐film transistor–liquid crystal display) industry is one of the key global industries with products that have high clock speed. In this research, the LCD monitor market is considered for an empirical study on hierarchical forecasting (HF). The proposed HF methodology consists of five steps. First, the three hierarchical levels of the LCD monitor market are identified. Second, several exogenously driven factors that significantly affect the demand for LCD monitors are identified at each level of product hierarchy. Third, the three forecasting techniques—regression analysis, transfer function, and simultaneous equations model—are combined to forecast future demand at each hierarchical level. Fourth, various forecasting approaches and disaggregating proportion methods are adopted to obtain consistent demand forecasts at each hierarchical level. Finally, the forecast errors with different forecasting approaches are assessed in order to determine the best forecasting level and the best forecasting approach. The findings show that the best forecast results can be obtained by using the middle‐out forecasting approach. These results could guide LCD manufacturers and brand owners on ways to forecast future market demands. Copyright 2008 John Wiley & Sons, Ltd.     

Control of a key transition from prostrate to erect growth in rice domestication

The transition from the prostrate growth of ancestral wild rice (O. rufipogon Griff.) to the erect growth of Oryza sativa cultivars was one of the most critical events in rice domestication. This evolutionary step importantly improved plant architecture and increased grain yield. Here we find that prostrate growth of wild rice from Yuanjiang County in China is controlled by a semi-dominant gene, PROG1 (PROSTRATE GROWTH 1), on chromosome 7 that encodes a single Cys(2)-His(2) zinc-finger protein. prog1 variants identified in O. sativa disrupt the prog1 function and inactivate prog1 expression, leading to erect growth, greater grain number and higher grain yield in cultivated rice. Sequence comparison shows that 182 varieties of cultivated rice, including 87 indica and 95 japonica cultivars from 17 countries, carry identical mutations in the prog1 coding region that may have become fixed during rice domestication.     

Heritable germline epimutation of MSH2 in a family with hereditary nonpolyposis colorectal cancer

Epimutations in the germline, such as methylation of the MLH1 gene, may contribute to hereditary cancer syndrome in human, but their transmission to offspring has never been documented. Here we report a family with inheritance, in three successive generations, of germline allele-specific and mosaic hypermethylation of the MSH2 gene, without evidence of DNA mismatch repair gene mutation. Three siblings carrying the germline methylation developed early-onset colorectal or endometrial cancers, all with microsatellite instability and MSH2 protein loss. Clonal bisulfite sequencing and pyrosequencing showed different methylation levels in different somatic tissues, with the highest level recorded in rectal mucosa and colon cancer tissue, and the lowest in blood leukocytes. This mosaic state of germline methylation with different tissue distribution could act as the first hit and provide a mechanism for genetic disease inheritance that may deviate from the mendelian pattern and be overlooked in conventional leukocyte-based genetic diagnosis strategy.     

金融系统的资源配置功能与经济增长

建立内生增长模型研究金融系统资源配置功能如何促进经济增长 .结论 :通过提高“创新平均成功概率”,增加“创新投资比例”、“储蓄转化比例”和储蓄率 ,金融系统能够促进经济快速稳定增长 .另外本文还得到产出 -资本比“阶跃”增长图象.     

灵敏度分析在惯导平台误差参数辨识中的应用

为了解决传统的惯导平台测漂方案下,惯导平台上陀螺安装误差角的系统级辨识精度不高的问题,对平台漂移的非线性模型进行了灵敏度分析,找出了影响陀螺安装误差角辨识精度的主要因素,进而提出了转台相对地面存在角速率条件下的改进辨识方案.仿真结果表明,在改进的辨识方案下误差角的辨识精度获得了显著提高.     

南黄海现代沉积环境及动力沉积体系

基于南黄海600多个表层沉积物样品的研究和对前人大量沉积学资料及水文学资料的分析, 阐述了南黄海现代沉积环境和动力沉积体系特征, 对存在广泛争议的泥质沉积物形成机制进行了探讨. 南黄海陆架可分为弱动力(低能)沉积环境和强动力(高能)环境, 低能沉积环境进一步划分为气旋型和反气旋型涡旋两种环境;高能环境则分为高能沉积环境和高能侵蚀环境. 陆架低能环境发育了泥质沉积体系. 在南黄海中部, 受海域中尺度气旋型涡旋(冷涡)的控制, 发育了冷涡泥质沉积体系, 而在南黄海东南部受反气旋型涡旋(暖涡)控制则形成了反气旋型涡旋泥质沉积体系(暖涡沉积). 二者在粒度、沉积速率、沉积厚度和矿物学特征上有明显区别. 陆架高能沉积环境发育了砂质沉积, 集中分布在南黄海的西部、南部及东北部海区, 在高能侵蚀环境区分布着大量砂岩砾石. 高能沉积环境中原有的细粒物质(黏土、细粉砂等)逐渐被悬浮、搬运至低能区沉积. 还建立了气旋型涡旋和反气旋型涡旋泥质沉积作用模式, 对南黄海泥质沉积体系的成因给出了系统的解释.