2,4,5,7-取代芳基苯并[b]呋喃类化合物的合成及其抗肿瘤活性

利用3-甲氧基-4-苄氧基苯乙炔化亚铜(1)和3-甲氧基-4-羟基-5-溴肉桂酸甲酯在吡啶中进行缩合反应合成2-(3-甲氧基-4-苄氧基苯基)-5-[2-甲氧基羰基-(E)-乙烯基]-7-甲氧基苯并[b]呋喃(2),2经过催化氢化反应得到化合物3,3进一步通过胺化、乙酰化、还原、水解、Vilsmeier反应、烷基化以及部分去甲基化等反应合成一系列2,4,5,7-取代芳基苯并[b]呋喃类化合物4～15,并通过IR、NMR、MS和元素分析确证了结构.并采用四唑盐比色法试验对部分化合物进行了体外抗肿瘤活性和细胞毒性测试,所测试化合物均显示出明显的细胞毒作用,其中化合物(9)的细胞毒性在所测试化合物中最强,对人口腔上皮癌细胞KB-3-1 IC50为1.71 μg/mL,具有良好的研究前景.     

固体氧化物燃料电池系统零排放新思路研究

提出了固体氧化物燃料电池零排放新思路设计,该设计具有高发电效率、温室气体零排放、回收利用二氧化碳以及使用环境友好的可再生循环二氧化碳吸收材料等优点.此外,还介绍了电池构件材料以及二氧化碳吸收材料的制备,最后测试了材料的二氧化碳吸附性能.结果表明最大体积吸收比可高达993倍,最佳吸收温度为700 ℃,同时可实现在800 ℃以上2 h内将所吸附的二氧化碳完全解析.     

红曲色素生产中代谢调控的研究进展

红曲色素由红曲霉发酵而得,它的发酵质量直接影响红曲色素的产量和质量.文章对近几年红曲色素发酵中代谢调控的研究进展以及控制过程中建立的数学模型作一简单介绍.     

《雨中的猫》中的二元对立结构

<雨中的猫>在乐趣/无聊二元对立不断重复的基础上,生动地传达出了由于社会性别的不同,男女主人公无法沟通,爱情已死亡,婚姻关系不正常的生活.     

我国科技中介服务体系建设中的制度障碍分析

简述了我国科技中介服务组织的发展现状，分析了影响我国科技中介组织发展的制度障碍，并就加强科技中介服务体系的制度创新提出了建议。     

土壤中磷素的有效性及其循环转化机制研究

磷是动植物生长所必需的元素,特别是植物.本文阐述了磷素在土壤中的形态及分类,重点分析了磷素的植物营养学原理、对植物的有效性及其影响因素,进而分析磷在全球尺度和土壤—植物系统中的循环机制;对于磷素的分级方法进行了总结,最后对磷素的研究进展及发展趋势提出了自己的观点.     

施氮量对不同穗型水稻品种生理特性的影响

以不同穗型水稻品种为试材，研究不同氮素水平对水稻生理特性的影响，结果表明：高氮水平下，两品种叶片中叶绿素含量、剑叶含氮量、单叶及群体光合速率、叶面积指数均高于低氮处理，下降速度也比低氮处理慢．这可能是直立穗型品种抽穗后物质生产能力强的生理原因．     

Pattern formation in Rayleigh-Bénard convection: Numerical simulation with a coupled-map-lattice model

The various patterns formed in Rayleigh-Bénard convection under different conditions are numerically simulated with a coupled-map-lattice model. In the case of a lower aspect ratio (L/d=5), the simulations vividly depicted the main features of the transition process from a laminar state to a soft turbulence and then to a hard turbulence. In this case, the cellular structure in a horizontal section is also reproduced. In the case of a larger aspect ratio (L/d=30), the simulations successfully reproduced the spiral-defect chaos and target chaos in the initial stage of the pattern evolution which were recently found in experiments. In this case, for a fluid ofPr=1, it is verified in simulations that both the ideal straight rolls and spiral-defect chaos are stable attractors in the same parameter regime, and that the initial condition is a decisive factor for which one of the two is formed. In the same case, for a fluid ofPr=4, the target patterns are dominant instead of the spirals, the sizes and distributions of the target are also notably dependent on the initial condition.     

Atomic-scale computer simulation for early precipitation process of Ni75AlxV25-x alloy with intermediate Al composition

The microscopic phase-field approach is applied to model the early precipitation process of Ni75AlxV25-x alloy. Without any prior assumptions, this model can be used to simulate the temporal evolution of arbitrary morphologies and microstructures on atomic scale. By simulating the atomic pictures, and calculating the order parameters and volume fraction of the θ (Ni3V) and γ'(Ni3Al) ordered phases, we study Ni75AlxV25-x alloys with Al composition of 0.05, 0. 053 and 0. 055 (atom fraction). Our calculated results show that,for these alloys, θ and γ' phases precipitate at the same time; with the increase of Al content, the amount of γ' phase increases and that of θ phase decreases; the precipitation characteristic of γ' phase transforms from Non-Classical Nucleation and Growth (NCNG) to Congruent Ordering Spinodal Decomposition (CO SD) gradually; otherwise, the precipitation characteristic of θ phase transforms from Congruent Ordering Spinodal Decomposition (CO SD) to Non-Classical Nucleation and Growth (NCNG) mechanism gradually. Both θ and γ' phases have undergone the transition process of mixture precipitation mechanism characterized by both NCNG and CO SD mechanisms. No incontinuous transition of precipitation mechanism has been found.     

中学化学教学中的设疑提问艺术初探

设疑提问是教和学的全方位活动.分析了当前中学化学教学中设疑提问中存在的问题,从设疑提问的要求和方法等方面进行了探讨.化学教学中艺术性设疑提问,有利于调动学生的学习积极性;发展学生的智力和创造性思维;培养学生的探索精神和分析、解决问题的能力.