高校体育专业学生裁判能力的培养

阐述了培养学生体育运动竞赛裁判能力的意义、方法及手段．为更好提高体育专业学生裁判水平,提出了体育运动竞赛项目的裁判培训学习的建议：（1）选好具有潜质的裁判员苗子;（2）加强理论指导并积极引导学生参与社会临场实践;（3）及时培训竞赛规则新知识,积极鼓励学生参加裁判等级晋升考核等．     

UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals

The gut-derived hormone ghrelin exerts its effect on the brain by regulating neuronal activity. Ghrelin-induced feeding behaviour is controlled by arcuate nucleus neurons that co-express neuropeptide Y and agouti-related protein (NPY/AgRP neurons). However, the intracellular mechanisms triggered by ghrelin to alter NPY/AgRP neuronal activity are poorly understood. Here we show that ghrelin initiates robust changes in hypothalamic mitochondrial respiration in mice that are dependent on uncoupling protein 2 (UCP2). Activation of this mitochondrial mechanism is critical for ghrelin-induced mitochondrial proliferation and electric activation of NPY/AgRP neurons, for ghrelin-triggered synaptic plasticity of pro-opiomelanocortin-expressing neurons, and for ghrelin-induced food intake. The UCP2-dependent action of ghrelin on NPY/AgRP neurons is driven by a hypothalamic fatty acid oxidation pathway involving AMPK, CPT1 and free radicals that are scavenged by UCP2. These results reveal a signalling modality connecting mitochondria-mediated effects of G-protein-coupled receptors on neuronal function and associated behaviour.     

RUP和UML在软件体系结构建模中的应用研究

把UML与RUP作为软件体系结构建模的支持,以某公司销售管理系统为例,根据UML与RUP的通用建模过程逐步构建了销售管理系统的需求模型、用例动态模型、对象结构模型和实现模型。