排序方式: 共有104条查询结果,搜索用时 15 毫秒
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This paper reports on a study in which an interpretive systems-based approach to knowledge elicitation, the Appreciative Inquiry Method (AIM), is used to elicit and record the expertise of what is referred to as a ??knowledge guardian??. A ??knowledge guardian?? is an individual who is a current repository and representative of some culturally-embedded knowledge which, for generations, has been passed on through teaching and apprenticeship, and continues to be so. Such knowledge is rich, complex and precious and merits protection. The knowledge guardian in this study is a Portuguese rider and teacher of Classical Dressage. His expertise relies heavily upon the ability to ??feel?? and explain such feeling in his teaching. The view of Classical Dressage that emerges from the study emphasises the importance of the individual??s psychological development and motivation to participate in the art due to a desire to experience ??brilliance??. The paper describes the process undertaken during the elicitation sessions and provides the models developed and used to facilitate the discussion. These models (Root Definition and Conceptual Model) are of the type commonly associated with Soft Systems Methodology. The paper also provides comments on the use of AIM, the knowledge recorded about Classical Dressage and the reflections of the two collaborators involved in the study. 相似文献
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Enterotypes of the human gut microbiome 总被引:6,自引:0,他引:6
Arumugam M Raes J Pelletier E Le Paslier D Yamada T Mende DR Fernandes GR Tap J Bruls T Batto JM Bertalan M Borruel N Casellas F Fernandez L Gautier L Hansen T Hattori M Hayashi T Kleerebezem M Kurokawa K Leclerc M Levenez F Manichanh C Nielsen HB Nielsen T Pons N Poulain J Qin J Sicheritz-Ponten T Tims S Torrents D Ugarte E Zoetendal EG Wang J Guarner F Pedersen O de Vos WM Brunak S Doré J;MetaHIT Consortium Antolín M Artiguenave F Blottiere HM Almeida M Brechot C Cara C Chervaux C Cultrone A 《Nature》2011,473(7346):174-180
Our knowledge of species and functional composition of the human gut microbiome is rapidly increasing, but it is still based on very few cohorts and little is known about variation across the world. By combining 22 newly sequenced faecal metagenomes of individuals from four countries with previously published data sets, here we identify three robust clusters (referred to as enterotypes hereafter) that are not nation or continent specific. We also confirmed the enterotypes in two published, larger cohorts, indicating that intestinal microbiota variation is generally stratified, not continuous. This indicates further the existence of a limited number of well-balanced host-microbial symbiotic states that might respond differently to diet and drug intake. The enterotypes are mostly driven by species composition, but abundant molecular functions are not necessarily provided by abundant species, highlighting the importance of a functional analysis to understand microbial communities. Although individual host properties such as body mass index, age, or gender cannot explain the observed enterotypes, data-driven marker genes or functional modules can be identified for each of these host properties. For example, twelve genes significantly correlate with age and three functional modules with the body mass index, hinting at a diagnostic potential of microbial markers. 相似文献
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Cornelius F Boerkoel Hiroshi Takashima Joy John Jiong Yan Pawel Stankiewicz Lisa Rosenbarker Jean-Luc André Radovan Bogdanovic Antoine Burguet Sandra Cockfield Isabel Cordeiro Stefan Fründ Friederike Illies Mark Joseph Ilkka Kaitila Giuliana Lama Chantal Loirat D Ross McLeod David V Milford Elizabeth M Petty Francisco Rodrigo Jorge M Saraiva Beate Schmidt Graham C Smith Jürgen Spranger Anja Stein Hannelore Thiele Jane Tizard Rosanna Weksberg James R Lupski David W Stockton 《Nature genetics》2002,30(2):215-220
Schimke immuno-osseous dysplasia (SIOD, MIM 242900) is an autosomal-recessive pleiotropic disorder with the diagnostic features of spondyloepiphyseal dysplasia, renal dysfunction and T-cell immunodeficiency. Using genome-wide linkage mapping and a positional candidate approach, we determined that mutations in SMARCAL1 (SWI/SNF2-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a-like 1), are responsible for SIOD. Through analysis of data from persons with SIOD in 26 unrelated families, we observed that affected individuals from 13 of 23 families with severe disease had two alleles with nonsense, frameshift or splicing mutations, whereas affected individuals from 3 of 3 families with milder disease had a missense mutation on each allele. These observations indicate that some missense mutations allow retention of partial SMARCAL1 function and thus cause milder disease. 相似文献
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The Acceptance and Progress in Argentina of Multi-Modal Systems Thinking for Community Development 总被引:1,自引:1,他引:0
Francisco Alejandro Casiello Juan Manuel Villarruel 《Systemic Practice and Action Research》2011,24(6):523-531
This article describes the acceptance and development of multi-modal systems thinking in Argentina in the last 5 years, both
in theory and in practice. On the theoretical side, we show the efforts made to provide compatible epistemological doctrines
for different modalities, starting with ethics and aesthetics. This took place first through the phenomenology of values and
more recently in the context of Christian existentialism and continuing later on with the study of the relationship among
other modalities. On the practical side, we describe the applications of this framework to study the so-called “crisis of
the Argentine countryside”. This is a conflict between the community of farmers, the national government and the present situation
with cattle producers. Other applications include a programme to teach action-research and projects related to abandoned children
and education in indigenous communities. 相似文献
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吴尧 《合肥工业大学学报(自然科学版)》2010,33(2)
整体性原则是建筑文化遗产保护中的一项基本原则,对整体性原则概念与内容的分析是制定保护方法和政策的重要依据,此外,对此原则概念发展过程的分析为中国建筑遗产保护工作提供了经验借鉴,并可以促进中国与世界在文化遗产保护工作方面的协同一致。 相似文献
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Garcia-Vidal FJ 《Nature》2006,440(7083):431-433
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