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91.
After eating, the human brain senses a biochemical change and then signals satiation, but precisely when this occurs is unknown. Even for well-established physiological systems like glucose-insulin regulation, the timing of interaction between hormonal processes and neural events is inferred mostly from blood sampling. Recently, neuroimaging studies have provided in vivo information about the neuroanatomical correlates of the regulation of energy intake. Temporal orchestration of such systems, however, is crucial to the integration of neuronal and hormonal signals that control eating behaviour. The challenge of this functional magnetic resonance imaging study is to map not only where but also when the brain will respond after food ingestion. Here we use a temporal clustering analysis technique to demonstrate that eating-related neural activity peaks at two different times with distinct localization. Importantly, the differentiated responses are interacting with an internal signal, the plasma insulin. These results support the concept of temporal parcellation of brain activity, which reflects the different natures of stimuli and responses. Moreover, this study provides a neuroimaging basis for detecting dynamic processes without prior knowledge of their timing, such as the acute effects of medication and nutrition in the brain. 相似文献
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Gal-Yam A Fox DB Price PA Ofek EO Davis MR Leonard DC Soderberg AM Schmidt BP Lewis KM Peterson BA Kulkarni SR Berger E Cenko SB Sari R Sharon K Frail D Moon DS Brown PJ Cucchiara A Harrison F Piran T Persson SE McCarthy PJ Penprase BE Chevalier RA MacFadyen AI 《Nature》2006,444(7122):1053-1055
Over the past decade, our physical understanding of gamma-ray bursts (GRBs) has progressed rapidly, thanks to the discovery and observation of their long-lived afterglow emission. Long-duration (> 2 s) GRBs are associated with the explosive deaths of massive stars ('collapsars', ref. 1), which produce accompanying supernovae; the short-duration (< or = 2 s) GRBs have a different origin, which has been argued to be the merger of two compact objects. Here we report optical observations of GRB 060614 (duration approximately 100 s, ref. 10) that rule out the presence of an associated supernova. This would seem to require a new explosive process: either a massive collapsar that powers a GRB without any associated supernova, or a new type of 'engine', as long-lived as the collapsar but without a massive star. We also show that the properties of the host galaxy (redshift z = 0.125) distinguish it from other long-duration GRB hosts and suggest that an entirely new type of GRB progenitor may be required. 相似文献
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Kulkarni SR Ofek EO Rau A Cenko SB Soderberg AM Fox DB Gal-Yam A Capak PL Moon DS Li W Filippenko AV Egami E Kartaltepe J Sanders DB 《Nature》2007,447(7143):458-460
Historically, variable and transient sources have both surprised astronomers and provided new views of the heavens. Here we report the discovery of an optical transient in the outskirts of the lenticular galaxy Messier 85 in the Virgo cluster. With a peak absolute R magnitude of -12, this event is distinctly brighter than novae, but fainter than type Ia supernovae (which are expected in a population of old stars in lenticular galaxies). Archival images of the field do not show a luminous star at that position with an upper limit in the g filter of about -4.1 mag, so it is unlikely to be a giant eruption from a luminous blue variable star. Over a two-month period, the transient source emitted radiation energy of almost 10(47) erg and subsequently faded in the optical sky. It is similar to, but six times more luminous at peak than, an enigmatic transient in the galaxy M31 (ref. 1). A possible origin of M85 OT2006-1 is a stellar merger. If so, searches for similar events in nearby galaxies will not only allow study of the physics of hyper-Eddington sources, but also probe an important phase in the evolution of stellar binary systems. 相似文献
96.
Localization of a human system for sustained attention by positron emission tomography 总被引:32,自引:0,他引:32
Positron emission tomographic (PET) studies of human attention have begun to dissect isolable components of this complex higher brain function, including a midline attentional system in a region of the anterior cingulate cortex. The right hemisphere may play a special part in human attention; neglect, an important phenomenon associated with damage to attentional systems, is more severe, extensive and long-lasting after lesions to the right hemisphere. Here we use PET measurements of brain blood flow in healthy subjects to identify changes in regional brain activity during simple visual and somatosensory tasks of sustained attention or vigilance. We find localized increases in blood flow in the prefrontal and superior parietal cortex primarily in the right hemisphere, regardless of the modality or laterality of sensory input. The anterior cingulate was not activated during either task. These data localize the vigilance aspects of normal human attention to sensory stimuli, thereby clarifying the biology underlying asymmetries of attention to such stimuli that have been reported in clinical lesions. 相似文献
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Résumé Les masses communes des amino-acides libres chezTetracladium setigerum etHeliscus submersus ont été analysées par des méthodes chromatographiques utilisant une couche mince de cellulose. Elles sont typiques pour la plupart des mycètes. Les amino-acides libres n'apparaissant que rarement ont été: l'hydroxyproline chezT. setigerum cultivé sur de l'acide glutamique, l'éthanolamine chezT. setigerum etH. submersus cultivé sur l'acide glutamique et enfin l'acide -aminobutyrique chezH. submersus avec comme nutrition la tyrosine. 相似文献
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Zusammenfassung Bei überschuss von Glutamins?ure und Asparagins?ure werden zahlreiche Aminos?uren thermisch kopolymerisiert. Das Studium der
Reaktionen und Nebenreaktionen führt zu einer Theorie über den thermischen Ursprung biochemischer Systeme.
Presented at a symposium on Biochemical Origins at the 133rd meeting of the American Chemical Society, San Francisco, April 17 1958. The research has been aided by Grant C-3971 of the National Institutes of Health, U. S. Public Health Service, Grant G-4566 of the National Science Foundation, and by the General Foods Corporation. Contribution No. 109 of the Oceanographic Institute of The Florida State University. 相似文献
Presented at a symposium on Biochemical Origins at the 133rd meeting of the American Chemical Society, San Francisco, April 17 1958. The research has been aided by Grant C-3971 of the National Institutes of Health, U. S. Public Health Service, Grant G-4566 of the National Science Foundation, and by the General Foods Corporation. Contribution No. 109 of the Oceanographic Institute of The Florida State University. 相似文献