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Pounds JA Bustamante MR Coloma LA Consuegra JA Fogden MP Foster PN La Marca E Masters KL Merino-Viteri A Puschendorf R Ron SR Sánchez-Azofeifa GA Still CJ Young BE 《Nature》2006,439(7073):161-167
As the Earth warms, many species are likely to disappear, often because of changing disease dynamics. Here we show that a recent mass extinction associated with pathogen outbreaks is tied to global warming. Seventeen years ago, in the mountains of Costa Rica, the Monteverde harlequin frog (Atelopus sp.) vanished along with the golden toad (Bufo periglenes). An estimated 67% of the 110 or so species of Atelopus, which are endemic to the American tropics, have met the same fate, and a pathogenic chytrid fungus (Batrachochytrium dendrobatidis) is implicated. Analysing the timing of losses in relation to changes in sea surface and air temperatures, we conclude with 'very high confidence' (> 99%, following the Intergovernmental Panel on Climate Change, IPCC) that large-scale warming is a key factor in the disappearances. We propose that temperatures at many highland localities are shifting towards the growth optimum of Batrachochytrium, thus encouraging outbreaks. With climate change promoting infectious disease and eroding biodiversity, the urgency of reducing greenhouse-gas concentrations is now undeniable. 相似文献
43.
Chemical weathering of the continents is central to the regulation of atmospheric carbon dioxide concentrations, and hence global climate. On million-year timescales silicate weathering leads to the draw-down of carbon dioxide, and on millennial timescales chemical weathering affects the calcium carbonate saturation state of the oceans and hence their uptake of carbon dioxide. However, variations in chemical weathering rates over glacial-interglacial cycles remain uncertain. During glacial periods, cold and dry conditions reduce the rate of chemical weathering, but intense physical weathering and the exposure of carbonates on continental shelves due to low sea levels may increase this rate. Here we present high-resolution records of the lead isotope composition of ferromanganese crusts from the North Atlantic Ocean that cover the past 550,000 years. Combining these records with a simple quantitative model of changes in the lead isotope composition of the deep North Atlantic Ocean in response to chemical weathering, we find that chemical weathering rates were two to three times lower in the glaciated interior of the North Atlantic Region during glacial periods than during the intervening interglacial periods. This decrease roughly balances the increase in chemical weathering caused by the exposure of continental shelves, indicating that chemical weathering rates remained relatively constant on glacial-interglacial timescales. On timescales of more than a million years, however, we suggest that enhanced weathering of silicate glacial sediments during interglacial periods results in a net draw-down of atmospheric carbon dioxide, creating a positive feedback on global climate that, once initiated, promotes cooling and further glaciation. 相似文献
44.
WF Laurance DC Useche J Rendeiro M Kalka CJ Bradshaw SP Sloan SG Laurance M Campbell K Abernethy P Alvarez V Arroyo-Rodriguez P Ashton J Benítez-Malvido A Blom KS Bobo CH Cannon M Cao R Carroll C Chapman R Coates M Cords F Danielsen B De Dijn E Dinerstein MA Donnelly D Edwards F Edwards N Farwig P Fashing PM Forget M Foster G Gale D Harris R Harrison J Hart S Karpanty WJ Kress J Krishnaswamy W Logsdon J Lovett W Magnusson F Maisels AR Marshall D McClearn D Mudappa MR Nielsen R Pearson N Pitman 《Nature》2012,489(7415):290-294
The rapid disruption of tropical forests probably imperils global biodiversity more than any other contemporary phenomenon. With deforestation advancing quickly, protected areas are increasingly becoming final refuges for threatened species and natural ecosystem processes. However, many protected areas in the tropics are themselves vulnerable to human encroachment and other environmental stresses. As pressures mount, it is vital to know whether existing reserves can sustain their biodiversity. A critical constraint in addressing this question has been that data describing a broad array of biodiversity groups have been unavailable for a sufficiently large and representative sample of reserves. Here we present a uniquely comprehensive data set on changes over the past 20 to 30 years in 31 functional groups of species and 21 potential drivers of environmental change, for 60 protected areas stratified across the world’s major tropical regions. Our analysis reveals great variation in reserve ‘health’: about half of all reserves have been effective or performed passably, but the rest are experiencing an erosion of biodiversity that is often alarmingly widespread taxonomically and functionally. Habitat disruption, hunting and forest-product exploitation were the strongest predictors of declining reserve health. Crucially, environmental changes immediately outside reserves seemed nearly as important as those inside in determining their ecological fate, with changes inside reserves strongly mirroring those occurring around them. These findings suggest that tropical protected areas are often intimately linked ecologically to their surrounding habitats, and that a failure to stem broad-scale loss and degradation of such habitats could sharply increase the likelihood of serious biodiversity declines. 相似文献
45.
Churchland MM Cunningham JP Kaufman MT Foster JD Nuyujukian P Ryu SI Shenoy KV 《Nature》2012,487(7405):51-56
Most theories of motor cortex have assumed that neural activity represents movement parameters. This view derives from what is known about primary visual cortex, where neural activity represents patterns of light. Yet it is unclear how well the analogy between motor and visual cortex holds. Single-neuron responses in motor cortex are complex, and there is marked disagreement regarding which movement parameters are represented. A better analogy might be with other motor systems, where a common principle is rhythmic neural activity. Here we find that motor cortex responses during reaching contain a brief but strong oscillatory component, something quite unexpected for a non-periodic behaviour. Oscillation amplitude and phase followed naturally from the preparatory state, suggesting a mechanistic role for preparatory neural activity. These results demonstrate an unexpected yet surprisingly simple structure in the population response. This underlying structure explains many of the confusing features of individual neural responses. 相似文献
46.
Toll-like receptors (TLRs) induce a multi-component inflammatory response that must be tightly regulated to avoid tissue damage. Most known regulatory mechanisms target TLR signalling pathways and thus broadly inhibit multiple aspects of the inflammatory response. Given the functional diversity of TLR-induced genes, we proposed that additional, gene-specific regulatory mechanisms exist to allow individual aspects of the TLR-induced response to be differentially regulated. Using an in vitro system of lipopolysaccharide tolerance in murine macrophages, we show that TLR-induced genes fall into two categories on the basis of their functions and regulatory requirements. We demonstrate that representatives from the two classes acquire distinct patterns of TLR-induced chromatin modifications. These gene-specific chromatin modifications are associated with transient silencing of one class of genes, which includes pro-inflammatory mediators, and priming of the second class, which includes antimicrobial effectors. These findings illustrate an adaptive response in macrophages and reveal component-specific regulation of inflammation. 相似文献
47.
Random components in mutagenesis 总被引:18,自引:0,他引:18
The mutability of DNA varies enormously from one base pair to another. Part of this variation is due to the specificity of the reaction between mutagens and base, but much of the variation is due to unknown causes. A genetic system developed by Miller and colleagues allows the mutation frequencies of a large number of different base pairs in the lacI gene of Escherichia coli to be compared. For example, Coulondre and Miller found that the sites most readily mutated by UV light are almost 100 times more often mutated than the least susceptible sites. A recently completed study of mutagenesis with neocarzinostatin (NCS) in the lacI gene has prompted us to re-examine some previous studies, of mutagenesis in this gene. Our analysis, reported here, suggests that the mutations induced by certain mutagens fall into two classes: mutations in one class are clearly distributed non-randomly, that is, they are very common at some sites and significantly less common at others; mutations in the second class, however, occur at low frequency and appear to be randomly distributed. Both classes of mutations seem to occur only at damaged bases. 相似文献
48.
Sequences homologous to ZFY, a candidate human sex-determining gene, are autosomal in marsupials 总被引:7,自引:0,他引:7
A H Sinclair J W Foster J A Spencer D C Page M Palmer P N Goodfellow J A Graves 《Nature》1988,336(6201):780-783
Sexual differentiation in placental mammals results from the action of a testis-determining gene encoded by the Y chromosome. This gene causes the indifferent gonad to develop as a testis, thereby initiating a hormonal cascade which produces a male phenotype. Recently, a candidate for the testis-determining gene (ZFY, Y-borne zinc-finger protein) has been cloned. The ZFY probe detects a male-specific (Y-linked) sequence in DNA from a range of eutherian mammals, as well as an X-linked sequence (ZFX) which maps to the human X chromosome. In marsupials it is also the Y chromosome that seems to determine the fate of the gonad, but not all sexual dimorphisms. Using the ZFY probe we find, surprisingly, that the ZFY homologous sequences are not on either the X or the Y chromosome in marsupials, but map to the autosomes. This implies ZFY is not the primary sex-determining gene in marsupials. Either the genetic pathways of sex determination in marsupials and eutherians differ, or they are identical and ZFY is not the primary signal in human sex determination. 相似文献
49.
50.
K. J. Collins K. G. Foster J. L. Hubbard 《Cellular and molecular life sciences : CMLS》1970,26(12):1313-1314
Zusammenfassung Nachweis, dass Natriumretention bei der menschlichen Temperaturregulation und in den exokrinen Schweissdrüsen der Handflächen von Aldosteron verursacht wird; dies im Unterschied zu den Drüsen in Katzenpfoten, welche charakteristischerweise vom exokrinen Sekretionsprozess des duktalen Ionenwechsels nicht beeinflusst werden und weder auf Aldosteron noch auf Blutung reagieren. 相似文献