Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons

We report that Sir2 activation through increased sir-2.1 dosage or treatment with the sirtuin activator resveratrol specifically rescued early neuronal dysfunction phenotypes induced by mutant polyglutamines in transgenic Caenorhabditis elegans. These effects are dependent on daf-16 (Forkhead). Additionally, resveratrol rescued mutant polyglutamine-specific cell death in neuronal cells derived from HdhQ111 knock-in mice. We conclude that Sir2 activation may protect against mutant polyglutamines.     

Mutations in dynamin 2 cause dominant centronuclear myopathy

Autosomal dominant centronuclear myopathy is a rare congenital myopathy characterized by delayed motor milestones and muscular weakness. In 11 families affected by centronuclear myopathy, we identified recurrent and de novo missense mutations in the gene dynamin 2 (DNM2, 19p13.2), which encodes a protein involved in endocytosis and membrane trafficking, actin assembly and centrosome cohesion. The transfected mutants showed reduced labeling in the centrosome, suggesting that DNM2 mutations might cause centronuclear myopathy by interfering with centrosome function.     

Increase in muscle fibres in the lateralis muscle (white portion) of Mugilidae (Pisces,Teleostei)

Summary A cycle of postlarval growth is described in the white portion of the lateralis muscle of Mugilidae. The cycle was identified histochemically by the myosin-ATPase reaction.This work was supported by a CNR grant (Oceanografia e fondi marini project).     

Structure de la sarpédobiline,pigment biliaire de Lépidoptère

Summary On the basis of NMR studies, mass spectrometry, chemical reactions and correlations with phorcabilin1, the structure2 is proposed for sarpedobilin, a butterfly blue bile pigment first isolated fromPapilio graphium sarpedon. This structure represents a new natural heterocyclic system.

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Nous remercions les Professeurs E. Lederer et J. Bergerard pour leur intérêt et le CEA Saclay pour une subvention ayant facilité l'achat des molécules isotopiques. Nous remercions aussi le D^r H. J. Veith, Darmstadt (République fédérale d'Allemagne), pour les mesures en spectrométrie de masse par désorption de champ.