排序方式: 共有43条查询结果,搜索用时 15 毫秒
31.
T. J. Fitzgerald 《Cellular and molecular life sciences : CMLS》1976,32(5):619-620
Summary The effect of SKF-525A and phenobarbirtal on the LD50 values of vinblastine and vincristine suggests that the toxicity of these agents in mice does not arise from a toxic metabolite.This work was supported by PHS Grant No. GM 15956. The author wishes to thankMary-Lucille Mantz for her valuable technical assistance and the Eli Lilly Company for graciously providing generous samples of VLB and VCR. The ample gift of SKF-525A from Smith, Kline and French Laboratories is also gratefully acknowledged. 相似文献
32.
Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1 总被引:48,自引:0,他引:48
M A Navia P M Fitzgerald B M McKeever C T Leu J C Heimbach W K Herber I S Sigal P L Darke J P Springer 《Nature》1989,337(6208):615-620
The crystal structure of the protease of the human immunodeficiency virus type (HIV-1), which releases structural proteins and enzymes from viral polyprotein products, has been determined to 3 A resolution. Large regions of the protease dimer, including the active site, have structural homology to the family of microbial aspartyl proteases. The structure suggests a mechanism for the autoproteolytic release of protease and a role in the control of virus maturation. 相似文献
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Antibody directed at a surface structure inhibits cytolytic but not suppressor function of human T lymphocytes 总被引:11,自引:0,他引:11
E L Reinherz R E Hussey K Fitzgerald P Snow C Terhorst S F Schlossman 《Nature》1981,294(5837):168-170
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As lithospheric plates are subducted, rocks are metamorphosed under high-pressure and ultrahigh-pressure conditions to produce eclogites and eclogite facies metamorphic rocks. Because chemical equilibrium is rarely fully achieved, eclogites may preserve in their distinctive mineral assemblages and textures a record of the pressures, temperatures and deformation the rock was subjected to during subduction and subsequent exhumation. Radioactive parent-daughter isotopic variations within minerals reveal the timing of these events. Here we present in situ zircon U/Pb ion microprobe data that dates the timing of eclogite facies metamorphism in eastern Papua New Guinea at 4.3 +/- 0.4 Myr ago, making this the youngest documented eclogite exposed at the Earth's surface. Eclogite exhumation from depths of approximately 75 km was extremely rapid and occurred at plate tectonic rates (cm yr(-1)). The eclogite was exhumed within a portion of the obliquely convergent Australian-Pacific plate boundary zone, in an extending region located west of the Woodlark basin sea floor spreading centre. Such rapid exhumation (> 1 cm yr(-1)) of high-pressure and, we infer, ultrahigh-pressure rocks is facilitated by extension within transient plate boundary zones associated with rapid oblique plate convergence. 相似文献
36.
Iva Hafner-Bratkovi? Mojca Ben?ina Katherine A. Fitzgerald Douglas Golenbock Roman Jerala 《Cellular and molecular life sciences : CMLS》2012,69(24):4215-4228
Prion diseases are fatal transmissible neurodegenerative diseases, characterized by aggregation of the pathological form of prion protein, spongiform degeneration, and neuronal loss, and activation of astrocytes and microglia. Microglia can clear prion plaques, but on the other hand cause neuronal death via release of neurotoxic species. Elevated expression of the proinflammatory cytokine IL-1β has been observed in brains affected by several prion diseases, and IL-1R-deficiency significantly prolonged the onset of the neurodegeneration in mice. We show that microglial cells stimulated by prion protein (PrP) fibrils induced neuronal toxicity. Microglia and macrophages release IL-1β upon stimulation by PrP fibrils, which depends on the NLRP3 inflammasome. Activation of NLRP3 inflammasome by PrP fibrils requires depletion of intracellular K+, and requires phagocytosis of PrP fibrils and consecutive lysosome destabilization. Among the well-defined molecular forms of PrP, the strongest NLRP3 activation was observed by fibrils, followed by aggregates, while neither native monomeric nor oligomeric PrP were able to activate the NLRP3 inflammasome. Our results together with previous studies on IL-1R-deficient mice suggest the IL-1 signaling pathway as the perspective target for the therapy of prion disease. 相似文献
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Genetic Analysis of Psoriasis Consortium & the Wellcome Trust Case Control Consortium Strange A Capon F Spencer CC Knight J Weale ME Allen MH Barton A Band G Bellenguez C Bergboer JG Blackwell JM Bramon E Bumpstead SJ Casas JP Cork MJ Corvin A Deloukas P Dilthey A Duncanson A Edkins S Estivill X Fitzgerald O Freeman C Giardina E Gray E Hofer A Hüffmeier U Hunt SE Irvine AD Jankowski J Kirby B Langford C Lascorz J Leman J Leslie S Mallbris L Markus HS Mathew CG McLean WH McManus R 《Nature genetics》2010,42(11):985-990
To identify new susceptibility loci for psoriasis, we undertook a genome-wide association study of 594,224 SNPs in 2,622 individuals with psoriasis and 5,667 controls. We identified associations at eight previously unreported genomic loci. Seven loci harbored genes with recognized immune functions (IL28RA, REL, IFIH1, ERAP1, TRAF3IP2, NFKBIA and TYK2). These associations were replicated in 9,079 European samples (six loci with a combined P < 5 × 10?? and two loci with a combined P < 5 × 10??). We also report compelling evidence for an interaction between the HLA-C and ERAP1 loci (combined P = 6.95 × 10??). ERAP1 plays an important role in MHC class I peptide processing. ERAP1 variants only influenced psoriasis susceptibility in individuals carrying the HLA-C risk allele. Our findings implicate pathways that integrate epidermal barrier dysfunction with innate and adaptive immune dysregulation in psoriasis pathogenesis. 相似文献
38.
Deborah Fitzgerald 《Annals of science》2013,70(4):341-342
The last charcoal iron blast furnace in the United States shut down in 1945. The most obvious reason for the extraordinary longevity of this industry was the almost unlimited supply of virgin timber in the United States. Although an obvious explanation, it is deceptive. The much more crucial reason for the longevity of the American charcoal iron industry was the technical difficulties involved in adapting coke- and coal-smelted iron to existing industrial processes. Until these technological problems could be overcome, charcoal iron was able to preserve a place for itself in the industrial environment of the late 19th and early 20th centuries. By concentrating their attention on the rapid advance of coke-smelted iron from 1870 onward, historians of the American iron industry have neglected this ability of the older iron technology to adapt to the new industrial conditions. 相似文献
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Barnes C Plagnol V Fitzgerald T Redon R Marchini J Clayton D Hurles ME 《Nature genetics》2008,40(10):1245-1252
Copy number variation (CNV) is pervasive in the human genome and can play a causal role in genetic diseases. The functional impact of CNV cannot be fully captured through linkage disequilibrium with SNPs. These observations motivate the development of statistical methods for performing direct CNV association studies. We show through simulation that current tests for CNV association are prone to false-positive associations in the presence of differential errors between cases and controls, especially if quantitative CNV measurements are noisy. We present a statistical framework for performing case-control CNV association studies that applies likelihood ratio testing of quantitative CNV measurements in cases and controls. We show that our methods are robust to differential errors and noisy data and can achieve maximal theoretical power. We illustrate the power of these methods for testing for association with binary and quantitative traits, and have made this software available as the R package CNVtools. 相似文献
40.
Scott J. Fitzgerald 《西北部美国博物学家》2011,59(2)
Plecia akerionana , n. sp., is described from the Green River Formation, Colorado, and diagnosed with P. minutula Rice, P. myersi Peterson, and P. rhodopterina Cockerell. Plecia intermedia (Scudder), the genotype of Mycetophaetus , and Plecia creedensis James are transferred to the genus Penthetria , and Hesperinus immutabilis Melander is transferred to Plecia . 相似文献