Output Tracking for One-Dimensional Wave Equation with Non-Collocated Control and Output Configuration

This paper considers output tracking for a one-dimensional wave equation with general disturbance which includes both internal nonlinear uncertainty and external disturbance. The performance output is non-collocated to the control. The disturbance is estimated by an essentially extended state observer from active disturbance rejection control and the difficulty caused by the non-collocated configuration of control and output is overcome by a proper trajectory planning. An output feedback law is proposed to make the tracking error be convergent to zero exponentially as time goes to infinity.At the same time, all states of the closed-loop system are shown to be uniformly bounded. Numerical simulation is also presented to validate the theoretical results.     

基于单月期限的沪深300ETF期权定价实证研究

针对在2019年12月份上市的沪深300ETF期权,收集其在2020年1～9月9个单月的市场真实交易数据,使用期权定价模型进行实证研究.借助经典B-S-M模型和考虑支付已知股息率B-S-M模型2种期权定价模型分别计算每个单月期限的沪深300ETF看涨看跌期权理论价,并与市场价综合比较后可知,支付已知股息率的B-S-M模...     

基于GIS、GPS、GSM的救护车智能管理系统研究

文章提出了一种救护车智能管理系统。该系统基于GIS、GPS、GSM技术,它能在发生紧急事故时,提供救护车到达出事地点,再从出事地点到达最近医院的最佳路径,该系统能够使救护车始终处于监控之下。我们通过设计有效的数据结构和算法来实现系统的上述功能。     

简单导联的非侵入便携式胎儿心电监护系统研究

提出并验证了一种简单导联方式实现的非侵入便携式胎儿心电监护仪的设计方案:以仪表放大器AD8220为核心,构建了母体胸导心电信号和腹壁混合信号的调理电路;通过AD7658实现A/D转换;然后将所得数字信号送入DSP芯片TMS320F28335,井通过USB通信模块CP2101将得到的心电信号数据传送到PC机。设计出了基于径向基函数的神经网络模块;提取出清晰的胎儿心电信号;调用绘图函数实现信号的实时显示。     

Genome-wide association studies of 14 agronomic traits in rice landraces

Uncovering the genetic basis of agronomic traits in crop landraces that have adapted to various agro-climatic conditions is important to world food security. Here we have identified ～ 3.6 million SNPs by sequencing 517 rice landraces and constructed a high-density haplotype map of the rice genome using a novel data-imputation method. We performed genome-wide association studies (GWAS) for 14 agronomic traits in the population of Oryza sativa indica subspecies. The loci identified through GWAS explained ～ 36% of the phenotypic variance, on average. The peak signals at six loci were tied closely to previously identified genes. This study provides a fundamental resource for rice genetics research and breeding, and demonstrates that an approach integrating second-generation genome sequencing and GWAS can be used as a powerful complementary strategy to classical biparental cross-mapping for dissecting complex traits in rice.     

韩国科技管理体制发展与演变探析

自20世纪60年代以来,韩国的科技发展取得了巨大的成就,其科技管理体制发挥了重要的作用.针对韩国科技管理体制形成与发展演变过程中经历的科技管理体系初步形成,以科技部为宏观管理决策部门的集中协调型管理体制,以及李明博政府对科技管理体制的重大调整等三个重要阶段进行了系统的分析研究,并对韩国科技管理体制的特点进行了总结和讨论.     

Maize HapMap2 identifies extant variation from a genome in flux

Whereas breeders have exploited diversity in maize for yield improvements, there has been limited progress in using beneficial alleles in undomesticated varieties. Characterizing standing variation in this complex genome has been challenging, with only a small fraction of it described to date. Using a population genetics scoring model, we identified 55 million SNPs in 103 lines across pre-domestication and domesticated Zea mays varieties, including a representative from the sister genus Tripsacum. We find that structural variations are pervasive in the Z. mays genome and are enriched at loci associated with important traits. By investigating the drivers of genome size variation, we find that the larger Tripsacum genome can be explained by transposable element abundance rather than an allopolyploid origin. In contrast, intraspecies genome size variation seems to be controlled by chromosomal knob content. There is tremendous overlap in key gene content in maize and Tripsacum, suggesting that adaptations from Tripsacum (for example, perennialism and frost and drought tolerance) can likely be integrated into maize.     

Genome-wide association study of flowering time and grain yield traits in a worldwide collection of rice germplasm

A high-density haplotype map recently enabled a genome-wide association study (GWAS) in a population of indica subspecies of Chinese rice landraces. Here we extend this methodology to a larger and more diverse sample of 950 worldwide rice varieties, including the Oryza sativa indica and Oryza sativa japonica subspecies, to perform an additional GWAS. We identified a total of 32 new loci associated with flowering time and with ten grain-related traits, indicating that the larger sample increased the power to detect trait-associated variants using GWAS. To characterize various alleles and complex genetic variation, we developed an analytical framework for haplotype-based de novo assembly of the low-coverage sequencing data in rice. We identified candidate genes for 18 associated loci through detailed annotation. This study shows that the integrated approach of sequence-based GWAS and functional genome annotation has the potential to match complex traits to their causal polymorphisms in rice.     

A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis

To identify susceptibility loci for ankylosing spondylitis, we performed a two-stage genome-wide association study in Han Chinese. In the discovery stage, we analyzed 1,356,350 autosomal SNPs in 1,837 individuals with ankylosing spondylitis and 4,231 controls; in the validation stage, we analyzed 30 suggestive SNPs in an additional 2,100 affected individuals and 3,496 controls. We identified two new susceptibility loci between EDIL3 and HAPLN1 at 5q14.3 (rs4552569; P = 8.77 × 10(-10)) and within ANO6 at 12q12 (rs17095830; P = 1.63 × 10(-8)). We also confirmed previously reported associations in Europeans within the major histocompatibility complex (MHC) region (top SNP, rs13202464; P < 5 × 10(-324)) and at 2p15 (rs10865331; P = 1.98 × 10(-8)). We show that rs13202464 within the MHC region mainly represents the risk effect of HLA-B*27 variants (including HLA-B*2704, HLA-B*2705 and HLA-B*2715) in Chinese. The two newly discovered loci implicate genes related to bone formation and cartilage development, suggesting their potential involvement in the etiology of ankylosing spondylitis.     

A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia

Non-obstructive azoospermia (NOA) is one of the most severe forms of male infertility. Its pathophysiology is largely unknown, and few genetic influences have been defined. To identify common variants contributing to NOA in Han Chinese men, we performed a three-stage genome-wide association study of 2,927 individuals with NOA and 5,734 controls. The combined analyses identified significant (P < 5.0 × 10(-8)) associations between NOA risk and common variants near PRMT6 (rs12097821 at 1p13.3: odds ratio (OR) = 1.25, P = 5.7 × 10(-10)), PEX10 (rs2477686 at 1p36.32: OR = 1.39, P = 5.7 × 10(-12)) and SOX5 (rs10842262 at 12p12.1: OR = 1.23, P = 2.3 × 10(-9)). These findings implicate genetic variants at 1p13.3, 1p36.32 and 12p12.1 in the etiology of NOA in Han Chinese men.