Specific binding of antigenic peptides to cell-associated MHC class I molecules

T lymphocytes recognize antigen in the form of peptides that associate with specific alleles of class I or class II major histocompatibility (MHC) molecules. By contrast with the clear MHC allele-specific binding of peptides to purified class II molecules purified solubilized class I molecules either bind relatively poorly or show degenerate specificity. Using photo-affinity labelling, we demonstrate here the specific interaction of peptides with cell-associated MHC class I molecules and show that this involves metabolically active processes.     

Genetic and photoperiodic control of an avian reproductive cycle

European blackcaps,Sylvia atricapilla, with one breeding season per year, have a single-peaked annual testes cycle. However, African conspecifics from the Cape Verde Islands with two breeding seasons per annum demonstrate a two-peaked cycle. Both population-specific cycles reflect differences in the respective endogenous circannual rhythms. Experimental hybridization of birds of the two populations resulted in an intermediate pattern of testes cycle, thus demonstrating that there are genetic components for some temporal aspects in an avian reproductive cycle. Another characteristic of the African birds, their extremely rapid juvenile development and early sexual maturity (at an age of 5–6 months) proved largely to be a photoperiodic (short-day) effect in birds hatched in autumn. The same effect could also be induced in European conspecifics exposed to correspondingly short day-lengths.     

Characterization of the rough endoplasmic reticulum ribosome-binding activity.

The rough endoplasmic reticulum membranes of mammalian cells contain specific ribosome-binding sites. A purification to apparent homogeneity of a negatively charged protein (ERp180) of relative molecular mass 180,000 (180 K) was reported which was proposed to function as a rough endoplasmic reticulum ribosome receptor. We report here that ribosome-binding site activity quantitatively solubilized from rough endoplasmic reticulum membranes does not cofractionate with ERp180. By contrast, ribosome-binding site activity fractionates as a much smaller, positively charged protein.     

磁控式异步电动机软起动器的开发与应用

详细介绍了将传统磁放大器用于异步电机降压起动、实现软起动功能的原理以及实际实现线路，是异步电机减压软起动技术领域的一项创新。     

预应力梁板施工中病害分析与对策

针对预应力梁板施工中常遇到的一些病害,对其中产生的原因进行了分析与探讨,并提出了具体的预防措施和处理方法。     

"看不见的手"与科学的繁荣

“看不见的手”在科学中扮演着重要的角色,科学家个人的自利行为可以增进科学共同体的利益。要发挥“看不见的手”的神奇作用,制度的设计与安排不可或缺。唯有科学制度有效地发挥作用,科学家个人的自我目标与科学的制度目标融为一体,私人利益与公共利益和谐一致,科学才会获得真正的成功与繁荣。     

现代工程图学教学方法及教学手段的研究与实践

根据现代工程图学课程特点及学生学习本门课程存在的问题,通过对传统教学和多媒体教学的利弊分析,提出了传统教学与多媒体教学有机结合是现代工程图学课堂教学有效的教学模式的观点,介绍了适应课堂教学的多媒体课件的制作方法.同时,提出了网络教学是远程学习、选修课学习和课外学习有效的教学模式的观点,介绍了网络教学的特点、教学方法及现代工程图学网络教学系统的内容.     

山西省部分非试点县农村新型合作医疗的调查

建立推广新型合作医疗的要点是:加大宣传力度;加强领导,发挥政府主导作用;强化监督,加强管理,确保基金安全平稳运行;创新服务机制,完善便民措施,实现服务管理一体化。