The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

The recycling of the amyloid precursor protein (APP) from the cell surface via the endocytic pathways plays a key role in the generation of amyloid beta peptide (Abeta) in Alzheimer disease. We report here that inherited variants in the SORL1 neuronal sorting receptor are associated with late-onset Alzheimer disease. These variants, which occur in at least two different clusters of intronic sequences within the SORL1 gene (also known as LR11 or SORLA) may regulate tissue-specific expression of SORL1. We also show that SORL1 directs trafficking of APP into recycling pathways and that when SORL1 is underexpressed, APP is sorted into Abeta-generating compartments. These data suggest that inherited or acquired changes in SORL1 expression or function are mechanistically involved in causing Alzheimer disease.     

非最小相位系统传递函数的演化模型降阶

针对非最小相位系统传递函数的模型降阶工作,通过对频域误差平方和加权的形式,提出了同时考虑频域幅值与相位因素的多目标参数优化指标。针对传统的求解多目标优化方法的不足,提出应用演化算法对此复杂的目标函数进行优化的策略。计算实例说明,使用演化优化方法可以获得幅值与相位特性均较好的降阶模型。     

基于构件建造信息系统的自适应体系结构

本文基于Ｈ．Ａ．Ｓｉｍｏｎ的决策认知过程分析,提出了一种用构件组装方式产生适应不同需求的信息系统。为了提高研制效率,给出了信息系统及其构件的形式化描述。在软件集成块 Ｓｏｆｔｗａｒｅ－ＩＣ的思路影响下提出了一种系统构成的自组织方法。     

An Adaptive Identification and Control Scheme Using Radial Basis Function Networks

1.INTaODUCTIONThemultilayerfeedforwardneuralnetworks(MFNN)hasbeenwidelyappliedinmanyfieldssuchaspatternrecognition,nonlinearoptimization,systemidentificationandcontrol.Thesimpleback-propagation(BP)learningalgorithmisusuallyadoptedtoupdateitsweights.TheBPalgorithm,however,suffersdrawbacksofslowconvergenceandunpredictablesolutionsduringlearning.Althoughmailyapproachessuchasvariablestepsize,conjugategradient,pseudo-Newtonmethods[4]andothermethods[3,10],havebeendevelopedtoovercometheproble…     

MetaOJ: A Massive Distributed Online Judge System

Online Judge(OJ) systems are a basic and important component of computer education. Here, we present MetaOJ, an OJ system that can be used for holding massive programming tests online. MetaOJ is designed to create a distributed, fault-tolerant, and easy-to-scale OJ system from an existing ordinary OJ system by adding several interfaces into it and creating multiple instances of it. Our case on modifying the TUOJ system shows that the modification adds no more than 3% lines of code and the performance loss on a single OJ instance is no more than 12%. We also introduce mechanisms to integrate the system with cloud infrastructure to automate the deployment process. MetaOJ provides a solution for those OJ systems that are designed for a specific programming contest and are now facing performance bottlenecks.     

A new method for uniform local heating deep in body using ultrasound phased-array system

A new method for targeted heating of deep tissue was developed by using an ultrasound phased-array system which can generate various multiple foci patterns by electronically changing its amplitude or phase pattern. This method involves using a technique of combining switching and rotating of multiple foci patterns to create a uniform temperature over tissue volumes in various size. Using this method, the target tissue deep in the body can be heated to a specified temperature, which gives conditions for thermo-sensitive liposomes release. A simulation study for a 108-element, spherically sectioned array was performed to determine an optimal heating scheme from a set of multiple focus fields which were produced by inputting different combinations of phases and amplitudes. Comparisons of a static multiple foci field, the switched fields and the switched-rotated fields indicated that the technique of combining switching and rotating of multiple foci patterns has advantages of both lowering the peak temperature and evening the temperature distribution. The simulation results also show that the therapeutic heating zones in various size employing the combined method. These results offer significant data for designing thermotherapy equipment for tumor-specific drug release with thermo-sensitive liposomes.     

Triazolotriazine-based thermally activated delayed fluorescence materials for highly efficient fluorescent organic light-emitting diodes (TSF-OLEDs)

Thermally activated delayed fluorescence (TADF) sensitized fluorescent organic light-emitting diodes (TSF-OLEDs) have shown great potential for the realization ...     

相对于一对代数集的局部上同调

设R为含幺交换环,X,y(∪)spec(R).在本文中,我们引入了相对于X,Y的广义局部上同调,并研究了它与一般局部上同调的关系及它的消失性.     

Attentional negativity bias moderated by positive mood arousal

Automatically allocation of more attention to negative stimuli is called emotional negativity bias. An event-related potentials (ERPs) experiment investigated whether or not this bias was altered by positive mood arousal. The results suggested that the attention bias towards negative stimuli was attenuated when positive information was accessible.     

文献检索与基于影响的摘要系统设计与实现

构建了一种新型文献检索系统,能够摘要一篇文献中引起读者研究工作关注的那些内容,并返回读者对这些内容的评论,从而帮助用户快速了解该文献的学术价值及不足之处等重要信息。利用文献间的引用关系从其他文献中找到指向一篇文献的评论上下文,借鉴查询-检索模式,将评论转化为一元语言模型所生成的查询,并将原文献划分为句子所构成的文档集,基于KL-divergence检索模型找到原文献中与评论对应的句子。选取得分最高的若干句子构成体现原文献对外影响的摘要。系统基于北京大学研制的智能搜索引擎平台Platform for Applying,Researching And Developing Intelligent Search Engine(PARADISE),具有快速构建可扩展好的优点。