KBe_2BO_3F_2的晶体角度调谐

基于三波耦合的能量、动量守恒条件和KBe2BO3F2(KBBF)晶体最新的色散方程,研究了共线Ⅰ类、Ⅱ类相位匹配和非共线Ⅰ类相位匹配KBBF晶体的角度调谐曲线;并比较了共线相位匹配和非共线相位匹配的特点.     

浅谈混凝土的温度与裂缝

通过多年的现场观察及查阅有关混凝土内部应力方面的专著,对混凝土温度裂缝产生的原因、现场混凝土温度的控制和预防裂缝的措施等进行了简单的阐述。     

脯氨酸-水二聚体分子间相互作用的理论研究

在B3LYP/6-311＋G（d,p）水平下优化得到了脯氨酸-水二聚体势能面上的4种低能优化构型。利用MP2/6-311＋G（d,p）方法计算脯氨酸-水二聚物平衡结构的偶极矩,原子电荷布居和分子间相互作用能。经BSSE校正后的相互作用能依次增强的顺序为Ⅳ〈Ⅱ〈Ⅰ〈Ⅲ,最稳定结构Ⅲ的相互作用能为-33.74 KJ/mol。     

PBL教学法在生物技术制药教学中的实践

生物技术制药是高等院校药学类专业的一门重要的专业课,为激发学生学习兴趣,提高教学质量,对生物技术制药课程教学作出改革,在教学过程中运用PBL教学模式。经过教学实践,取得了较好的教学效果。     

大学生网络消费行为影响因素的研究

为了引导大学生正确的网络消费,同时也为商家提供合理的网上营销策略,通过网上问卷的形式,对466名在校大学生进行网络消费调查,对回收的数据进行描述性统计分析,对量表进行效度与信度分析,分析结果表明,大多数大学生认为网络购物的可信度在60%~90%,商家信誉与产品质量是大学生最为关注的。     

Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration

The neuropathological hallmarks of Alzheimer's disease and other tauopathies include senile plaques and/or neurofibrillary tangles. Although mouse models have been created by overexpressing specific proteins including beta-amyloid precursor protein, presenilin and tau, no model has been generated by gene knockout. Phosphorylation of tau and other proteins on serine or threonine residues preceding proline seems to precede tangle formation and neurodegeneration in Alzheimer's disease. Notably, these phospho(Ser/Thr)-Pro motifs exist in two distinct conformations, whose conversion in some proteins is catalysed by the Pin1 prolyl isomerase. Pin1 activity can directly restore the conformation and function of phosphorylated tau or it can do so indirectly by promoting its dephosphorylation, which suggests that Pin1 is involved in neurodegeneration; however, genetic evidence is lacking. Here we show that Pin1 expression is inversely correlated with predicted neuronal vulnerability and actual neurofibrillary degeneration in Alzheimer's disease. Pin1 knockout in mice causes progressive age-dependent neuropathy characterized by motor and behavioural deficits, tau hyperphosphorylation, tau filament formation and neuronal degeneration. Thus, Pin1 is pivotal in protecting against age-dependent neurodegeneration, providing insight into the pathogenesis and treatment of Alzheimer's disease and other tauopathies.     

管理咨询业的发展历程及其动因分析

介绍了管理咨询业的发展历程,从社会经济与技术的发展、企业经营管理的专业化、管理理论与实践的发展、社会需求的发展等方面分析了管理咨询业发展的动因。     

A New Method with High Confidence for Validation of Computer Simulation Models of Flight Systems

Computer simulation models may by used to gain further information about missile performance variability. Model validation is an important aspect of the test program for a missile system. Validation provides a basis for confidence in the model's results and is a necessary step if the model is to be used to draw inference about the behavior of the real missile. This paper is a review of methods useful for validation of computer simulation models of missile systems and provides a new method with high degree of confidence for validation of computer simulation models of missile systems. Some examples of the use of the new method in validating computer simulation models are given.     

长纤维高速过滤器的运行动力学研究

为对长纤维高速过滤器的模拟分析、运行控制及效果预测提供理论依据,在深入分析长纤维高速过滤器深层过滤机理及积泥形态的基础上,结合试验观察,借鉴半经验、半理论模型,建立了用以表征长纤维高速过滤器运行特性的水头损失方程及传质动力学模型.通过大量试验测定和对初始滤速为30 m/h时的模型计算与实测结果的比较表明,除沉淀出水过滤前期滤出水浊度计算值与实测值误差较大外,其余各范围计算值均吻合良好,证明了假设的合理性及模型的有效性.     

高铬白口铸铁抗磨粒磨损耐磨性与断裂韧性的研究

本文研究了两种基体组织状态及碳化物体积分数对高铬白口铸铁抗磨粒磨损耐磨性、断裂韧性K_(IC)、K_(Id)及亚临界裂纹扩展速率da/dN的影响。结果表明:高铬白口铸铁耐磨性与磨损系统有关;而其断裂韧性及亚临界裂纹扩展速率与基体组织状态、碳化物体积分数及其形态与分布有关。综合研究结果,从高铬白口铸铁耐磨性与断裂韧性最优化角度考虑,如果用软磨料,宜选用马氏体基体;采用硬磨料,则宜选用奥氏体基体。