Finding finer functions for partially characterized proteins by protein-protein interaction networks

Based on high-throughput data, numerous algorithms have been designed to find functions of novel proteins. However, the effectiveness of such algorithms is currently limited by some fundamental factors, including (1) the low a-priori probability of novel proteins participating in a detailed function; (2) the huge false data present in high-throughput datasets; (3) the incomplete data coverage of functional classes; (4) the abundant but heterogeneous negative samples for training the algorithms; and (5) the lack of detailed functional knowledge for training algorithms. Here, for partially characterized proteins, we suggest an approach to finding their finer functions based on protein interaction sub-networks or gene expression patterns, defined in function-specific subspaces. The proposed approach can lessen the above-mentioned problems by properly defining the prediction range and functionally filtering the noisy data, and thus can efficiently find proteins’ novel functions. For thousands of yeast and human proteins partially characterized, it is able to reliably find their finer functions (e.g., the translational functions) with more than 90% precision. The predicted finer functions are highly valuable both for guiding the follow-up wet-lab validation and for providing the necessary data for training algorithms to learn other proteins.     

信息技术环境下儿童语言发展促进研究

在儿童语言发展特征与人类语言习得理论的基础上,探讨信息技术环境下,利用信息技术促进儿童口语、书面语发展的方法和策略以及要注意的问题。     

CGPSS-F仿真系统数据的采集与分析

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H—列闭空间与H—序列闭空间

本文引进了θ-聚点,II-列闭空间与II-序列闭空间的概念,并对II-可数闭空间、II-列闭空间、II-序列闭空间建立了一些关系.     

部分充满介质的理想螺线管条件

一般教科书中都提到，理想螺线管（指内部磁场均匀，无漏磁）的条件是无限长（相对而言），绕线蜂蜜。但对绕线是否应该均匀则未做详细论述。本文试图指出，在无介质情况下理想螺线管的绕线都是均匀的，但在部分充满介质的情况下，均匀的绕线反而会破坏“理想”的条件。     

均匀带电圆环的电势

从电势的一般概念出发得出均匀带电圆环的公式，并讨论在极限情况下约化为均匀带电细圆环的电势公式。     

GIANT MAGNETORESISTANCE EFFECTS IN Co／Cu （111） SUPERLATTICE

We present a spin-dependent scattering theory to explain the new type of magnetoresistance effect and magnetization in Co/Cu(111) su-perlattice with atomically smooth interfaces. Our model is simple, but the calculated results are consistent with the experimental ones.     

维哈柯汉英多媒体触摸咨询应用系统的研制

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