排序方式: 共有37条查询结果,搜索用时 929 毫秒
11.
Sahin E Colla S Liesa M Moslehi J Müller FL Guo M Cooper M Kotton D Fabian AJ Walkey C Maser RS Tonon G Foerster F Xiong R Wang YA Shukla SA Jaskelioff M Martin ES Heffernan TP Protopopov A Ivanova E Mahoney JE Kost-Alimova M Perry SR Bronson R Liao R Mulligan R Shirihai OS Chin L DePinho RA 《Nature》2011,470(7334):359-365
12.
最新的研究显示,黑洞也能成为明亮的辐射源——在吸积周围物质的过程中,当吸积盘中的气体盘旋着掉入黑洞时会释放出大量的引力能,这些辐射为我们认识黑洞边缘的秘密提供了一条途径。 黑洞的辐射主要来自吸积盘的热辐射。其中的幂律硬X射线是来自吸积盘的光子和吸积盘冕中热电子互相作用的结果。这一光谱已经在恒星质量黑洞中 相似文献
13.
Manfred Breit Manfred Vogel Fritz Hubi Fabian Mrki Micheal Raps iDs University of Applied Sciences Northwestern Switzerland Steinackerstrasse CH- Windisch Switzerland 《清华大学学报》2008,13(Z1):179-184
The objective of this ongoing joint research program is to determine how 3D/4D modeling, simulation and visualization of Products (buildings), Organizations and Processes (POP) can support lean construction. Initial findings suggest that Process Design Pattern may have the potential to intuitively support ICT based lean construction. We initiated a "Process Archeology" in order to reveal the requirements for tools that can support the planning, simulation and control of lean construction methods. First findings show that existing tools provide only limited support and therefore, we started to develop new methodologies and technologies to overcome these shortcomings. Through the introduction of Process Design Patterns, we intent to establish process thinking in the interdisciplinary POP design. Optimized construction processes may be synthesized with semi-automatic methods by applying Process Design Patterns on building structures. By providing process templates that integrate problem solution and expert knowledge, Process Design Patterns may have the potential to ensure high quality process models. 相似文献
14.
The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae
Kurz T Ozlü N Rudolf F O'Rourke SM Luke B Hofmann K Hyman AA Bowerman B Peter M 《Nature》2005,435(7046):1257-1261
SCF-type E3 ubiquitin ligases are multi-protein complexes required for polyubiquitination and subsequent degradation of target proteins by the 26S proteasome. Cullins, together with the RING-finger protein Rbx1, form the catalytic core of the ligase, and recruit the substrate-recognition module. Cycles of covalent modification of cullins by the ubiquitin-like molecule Nedd8 (neddylation) and removal of Nedd8 by the COP9 signalosome (deneddylation) positively regulate E3 ligase activity. Here we report the identification and analysis of a widely conserved protein that is required for cullin neddylation in the nematode Caenorhabditis elegans and the yeast Saccharomyces cerevisiae. C. elegans DCN-1 and S. cerevisiae Dcn1p (defective in cullin neddylation) are characterized by a novel UBA-like ubiquitin-binding domain and a DUF298 domain of unknown function. Consistent with their requirements for neddylation, DCN-1 and Dcn1p directly bind Nedd8 and physically associate with cullins in both species. Moreover, overexpression of Dcn1p in yeast results in the accumulation of Nedd8-modified cullin Cdc53p. Both in vivo and in vitro experiments indicate that Dcn1p does not inhibit deneddylation of Cdc53p by the COP9 signalosome, but greatly increases the kinetics of the neddylation reaction. 相似文献
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16.
Fabian AC Johnstone RM Sanders JS Conselice CJ Crawford CS Gallagher JS Zweibel E 《Nature》2008,454(7207):968-970
The giant elliptical galaxy NGC 1275, at the centre of the Perseus cluster, is surrounded by a well-known giant nebulosity of emission-line filaments, which are plausibly in excess of 10(8) years old. The filaments are dragged out from the centre of the galaxy by radio-emitting 'bubbles' rising buoyantly in the hot intracluster gas, before later falling back. They act as markers of the feedback process by which energy is transferred from the central massive black hole to the surrounding gas. The mechanism by which the filaments are stabilized against tidal shear and dissipation into the surrounding extremely hot (4 x 10(7) K) gas has been unclear. Here we report observations that resolve thread-like structures in the filaments. Some threads extend over 6 kpc, yet are only 70 pc wide. We conclude that magnetic fields in the threads, in pressure balance with the surrounding gas, stabilize the filaments, so allowing a large mass of cold gas to accumulate and delay star formation. 相似文献
17.
Fabian Fernandez Viviana Torres Pedro Zamorano 《Cellular and molecular life sciences : CMLS》2010,67(11):1751-1754
Presynaptic differentiation takes place over three interrelated acts involving the biogenesis and trafficking of molecular
complexes of active zone material, the “trapping” or stabilization of active zone sites, and the subsequent development of
mature synapses. Although the identities of proteins involved with establishing presynaptic specializations have been increasingly
delineated, the exact functional mechanisms by which the active zone is assembled remain poorly understood. Here, we discuss
a theoretical model for how the trapping stage of presynaptic differentiation might occur in developing neurons. We suggest that subsets of active zone proteins containing
polyglutamine domains undergo concentration-dependent prion-like conversions as they accumulate at the plasma membrane. This
conversion might serve to aggregate the proteins into a singular structure, which is then able to recruit scaffolding agents
necessary for regulated synaptic transmission. A brief informatics analysis in support of this ‘Q’ assembly hypothesis—across
commonly used models of synaptogenesis—is presented. 相似文献
18.
In this paper we propose a new method for evaluating image recording strategies for limited angle tomography.In limited angle tomography exact three-dimensional(3-D) reconstruction is not achievable.With this method a metric for the reachable reconstruction quality by defined X-ray source trajectories is calculated.The result of our method is independent of reconstruction algorithms.Our approach is based on the gradients of the scanned volume and their grade of determinability.Compared to simulated reconstr... 相似文献
19.
Miller JM Raymond J Fabian A Steeghs D Homan J Reynolds C van der Klis M Wijnands R 《Nature》2006,441(7096):953-955
Although disk accretion onto compact objects-white dwarfs, neutron stars and black holes-is central to much of high-energy astrophysics, the mechanisms that enable this process have remained observationally difficult to determine. Accretion disks must transfer angular momentum in order for matter to travel radially inward onto the compact object. Internal viscosity from magnetic processes and disk winds can both in principle transfer angular momentum, but hitherto we lacked evidence that either occurs. Here we report that an X-ray-absorbing wind discovered in an observation of the stellar-mass black hole binary GRO J1655 - 40 (ref. 6) must be powered by a magnetic process that can also drive accretion through the disk. Detailed spectral analysis and modelling of the wind shows that it can only be powered by pressure generated by magnetic viscosity internal to the disk or magnetocentrifugal forces. This result demonstrates that disk accretion onto black holes is a fundamentally magnetic process. 相似文献
20.
低碳锰钢中周期性带状组织 总被引:6,自引:0,他引:6
用扫描电镜和电子探针研究了低碳锰钢中的周期性带状组织,结果表明,在全部研究用钢中,钢锭经热轧后均出现这种组织,其严重程度随钢的成分而异,并随坯带加工顺序而增加,带状组织与锰的显微偏析等因素有关,适当的调整碳锰以及形成模跨铁素体带的转变产物可降低带状组织的严重程度。 相似文献