A PPARγ-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis

Although feast and famine cycles illustrate that remodelling of adipose tissue in response to fluctuations in nutrient availability is essential for maintaining metabolic homeostasis, the underlying mechanisms remain poorly understood. Here we identify fibroblast growth factor 1 (FGF1) as a critical transducer in this process in mice, and link its regulation to the nuclear receptor PPARγ (peroxisome proliferator activated receptor γ), which is the adipocyte master regulator and the target of the thiazolidinedione class of insulin sensitizing drugs. FGF1 is the prototype of the 22-member FGF family of proteins and has been implicated in a range of physiological processes, including development, wound healing and cardiovascular changes. Surprisingly, FGF1 knockout mice display no significant phenotype under standard laboratory conditions. We show that FGF1 is highly induced in adipose tissue in response to a high-fat diet and that mice lacking FGF1 develop an aggressive diabetic phenotype coupled to aberrant adipose expansion when challenged with a high-fat diet. Further analysis of adipose depots in FGF1-deficient mice revealed multiple histopathologies in the vasculature network, an accentuated inflammatory response, aberrant adipocyte size distribution and ectopic expression of pancreatic lipases. On withdrawal of the high-fat diet, this inflamed adipose tissue fails to properly resolve, resulting in extensive fat necrosis. In terms of mechanisms, we show that adipose induction of FGF1 in the fed state is regulated by PPARγ acting through an evolutionarily conserved promoter proximal PPAR response element within the FGF1 gene. The discovery of a phenotype for the FGF1 knockout mouse establishes the PPARγ–FGF1 axis as critical for maintaining metabolic homeostasis and insulin sensitization.     

Observation of robust edge superconductivity in Fe(Se,Te) under strong magnetic perturbation

The iron-chalcogenide high temperature superconductor Fe(Se,Te) (FST) has been reported to exhibit complex magnetic ordering and nontrivial band topology which ...     

红桤木花粉生活力及其贮藏方法的研究

以红桤木花粉为试材,用TTC染色法和离体培养法对其生活力进行了测定,同时探讨了不同贮藏方法对花粉生活力的影响。结果表明：TTC法不适于红桤木花粉生活力的测定;花粉在10 %蔗糖+0.1 %硼酸的培养基上培养8 h后萌发率最高;随着贮藏时间的延长红桤木花粉生活力下降,其适宜贮藏温度为-20 ℃;超低温保存中花粉以自来水冲洗解冻效果最好,但超低温保存并没有延长花粉保存时间。     

5′—硝基水杨基荧光酮—N—氯化十六烷基吡啶分光光度法测定微量铜

详细研究了 5′-硝基水杨基荧光酮 -CPC与铜形成三元络合物的显色反应条件和光度性质 ,结果表明 :在 p H6.55的缓冲溶液中 ,铜与试剂形成三元络合物 ,其最大波长在 563 nm,表观摩尔吸光系数为 1 .3 6× 1 0 5L· m ol-1· cm-1,铜含量在 0～ 7μg/2 5ml范围内符合比耳定律 ,本法通过巯基棉分离 ,测定了环境水样中铜的含量 ,结果较好     

谈同步检波

通过对同步检波的分析,论述其原理类型及实现方法,使读者对同步检波有更加清楚的理解和认识.     

关于序进应力加速寿命试验中若干问题的探讨

采用若干基本假定,用分段函数连续化方法,给出了在恒定应力条件下寿命服从指数分布或威氏分布的产品,在序进应力加速寿命试验中的寿命分布;并给出了在加速寿命方程满足逆幂律且等速加载情况下的具体分布形式.文中还利用序进应力试验中所获得的数据,应用极大似然估计法估计加速寿命方程与寿命分布中的参数,并对参数估计值的性质进行了讨论.     

解放CA-141型汽车最优二级维护周期研究

结合CA－141型汽车运行生产实际，在计划预防方针指导下，借助于可靠性理论、更新理论、优化理论等，建立确定汽车最优维护周期的数学模型．并具体求出CA－141型汽车的最优二级维护周期里程．本文提供方法亦可应用于其它国产和进口汽车最优维护周期的确定。     

医学图像分割技术新进展

医学影像技术已成为医学技术中发展最快的领域之一,医学图像分割技术是医学图像处理和分析中的关键技术.在大量阅读国内外近期文献的基础上,对近年来医学图像分割技术的发展进行了分类综述,分别阐述了基于模糊算法、基于知识、基于神经网络、基于遗传算法、基于小波变换、基于数学形态学的分割算法,并根据最新文献介绍了其最新发展情况.     

芡实生物学特性的研究

试验采用对角线取样法,每点取5株芡实作为研究对象,从幼苗期开始对芡实的植物学特征,生长状况以及农艺性状等方面进行研究．结果表明,芡实叶柄长156．5cm,直径2．6cm,单茎重0．94kg,单株叶柄数10个,产量为20848．4kg·hm-2;芡实种子单粒重0．22g,直径6mm,单株果数15个,产量647．1kg．hm-2,每公顷可为农民增收99572．1元,具有非常高的经济价值和广阔的发展前景．     

一种公钥密码体制下指纹识别与数字水印的身份认证协议

在公钥密码PKI(Public Key Infrastructure)安全体制下,结合指纹识别与数字水印的各自特性,提出了一种基于指纹特征作为数字水印的网络身份认证协议。由数据交互过程的分析可见,此协议方案能充分保证用户密钥和指纹信息的保密性和真实性,并能有效抵抗Stolen-verifier和Replay Attack两种攻击,可用于电子商务环境下高安全性的身份认证系统。