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991.
F. Ajmar G. F. Gaetani C. Garrè G. F. Paravidino E. Salvidio 《Cellular and molecular life sciences : CMLS》1972,28(5):572-574
Riassunto L'incubazione di lisati piastrinici con NADP provoca inattivazione della 6PGD e ne modifica la migrazione elettroforetica. Non si osserva invece attivazione della GSSG-R.
Supported by a grant from the Consiglio Nazionale delle Ricerche Contratto No 70.00378/18/115.3565. Roma (Italy). 相似文献
Supported by a grant from the Consiglio Nazionale delle Ricerche Contratto No 70.00378/18/115.3565. Roma (Italy). 相似文献
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Résumé L'incorporation des atomes radioactifs de 1-14C-pyruvate dans le cerveau des souris est plus marquée quand les animaux ont soumis à un isolement prolongé.
This study was supported by the United States Public Health Service (FVD) and by MH No. 15352 (RMP). 相似文献
This study was supported by the United States Public Health Service (FVD) and by MH No. 15352 (RMP). 相似文献
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A single human gene encoding multiple tyrosine hydroxylases with different predicted functional characteristics 总被引:21,自引:0,他引:21
Catecholaminergic systems in discrete regions of the brain are thought to be important in affective psychoses, learning and memory, reinforcement and sleep-wake cycle regulation. Tyrosine hydroxylase (TH) is the first enzyme in the pathway of catecholamine synthesis. Its importance is reflected in the diversity of the mechanisms that have been described which control its activity; TH levels vary both during development and as a function of the activity of the nervous system. Recently, we deduced the complete amino-acid sequence of rat TH from a complementary DNA clone encoding a functional enzyme. Here we demonstrate that, in man, TH molecules are encoded by at least three distinct messenger RNAs. The expression of these mRNAs varies in different parts of the nervous system. The sequence differences observed are confined to the 5' termini of the messengers and involve alternative splicing events. This variation has clear functional consequences for each putative form of the enzyme and could represent a novel means of regulating catecholamine levels in normal and pathological neurons. 相似文献
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In early embryonic development the basic body plan arises because cells in different regions become programmed to follow different developmental pathways. We have proposed that in the early amphibian embryo this process of regional specification arises from the action of three different inducing factors, or morphogens, but we have not until now had any idea of their chemical nature. In this paper we report that pure basic fibroblast growth factor (bFGF), at very low concentrations and with high specificity, closely mimics the effect of the ventrovegetal (VV) signal and that the transmission of the natural VV signal can be blocked by heparin, suggesting that it may be a heparin-binding factor such as bFGF. 相似文献
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