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141.
Two classes of metabolites fromTheonella swinhoei are localized in distinct populations of bacterial symbionts 总被引:7,自引:0,他引:7
C. A. Bewley N. D. Holland D. J. Faulkner 《Cellular and molecular life sciences : CMLS》1996,52(7):716-722
The marine spongeTheonella swinhoei (lithistid Family Theonellidae, Order Astrophorida) has yielded many important, bioactive natural products, most of which share structural features with bacterial natural products. The presence of microbial symbionts inT. swinhoei has been reported, and it was originally suggested that the cytotoxic macrolide swinholide A and many of the bioactive cyclic peptides fromT. swinhoei were all produced by symbiotic cyanobacteria. By transmission electron microscopy, we found four distinct cell populations to be consistently present inT. swinhoei: eukaryotic sponge cells, unicellular heterotrophic bacteria, unicellular cyanobacteria and filamentous heterotrophic bacteria. Purification and chemical analyses of each cell type showed the macrolide swinholide A to be limited to the mixed population of unicellular heterotrophic bacteria, and an anti-fungal cyclic peptide occurred only in the filamentous heterotrophic bacteria. Contrary to prior speculation, no major metabolites were located in the cyanobacteria or sponge cells. 相似文献
142.
李少霞 《国外科技新书评介》2006,(1):22-22
本书属于矿物物理领域,重点是矿物的发光光谱。本书使用的实验手段主要是激光激发矿物质和对其发射和散射结果进行时间分辨的探测。全书共11章。第1章简介,介绍了主要科学术语的定义以及激光诱导时间分辨技术和稳态发光等内容;第2章理论背景,解释了激发能的吸收、辐射跃迁等发光中的主要过程;第3章实验方法,描述了实验设备的主要部分; 相似文献
143.
侯力群 《国外科技新书评介》2006,(10):7-7
本书是2003年春季美国化学工程协会召开的“气体水合物讨论会”的论文集,共收录16篇论文。气体水合物是一种非常特殊的化学组成,它是由水分子(主体分子)包裹着气体分子(客体分子)在低温高压条件下形成的一种无化学键的晶体物质。通常的气体水合物是甲烷水合物,在常温常压下,甲烷水合物中包含的甲烷气体是甲烷水化物本身的180倍。作为一种替补能源,气体水合物的研究已经越来越受到人们的重视。 相似文献
144.
钱桂安 《国外科技新书评介》2006,(10):13-13
本书是关于城市交通管理的一本论文集,是根据2003年在瑞典召开的“未来城市交通:如何应对城市交通发展的复杂性”学术会议上宣读的论文编著而成。这次会议是由沃尔沃研究教育基金资助。本书阐述了多个城市交通的特点、复杂性的概念、如何应对复杂性、汽车交通系统的作用。并对亚洲、非洲、欧洲等多国的交通系统模型做出了分析,提出了解决交通问题的一些措施。 相似文献
145.
The pericratonic sedimentary Jaisalmer Basin, west of the Aravalli Ranges, on the westerly dipping eastern flank of the Indus Shelf, is a principal structural element of Rajasthan. Jurassic sediments in the SE comprise non-marine sandstones and conglomerates to nearshore, brackish to marine sands, silts, clays and carbonates, grouped lithostratigraphically into the Lathi, Jaisalmer, Baisakhi, and Bhadasar formations. The Late Bajocian to Oxfordian Jaisalmer Formation is divided, in ascending order, into the Hamira, Joyan, Fort, Badabag, Kuldhar, and Jajiya members. Fossil records providing a Bajocian to Bathonian age for the lower and middle parts of the formation include: a Late Bajocian coral Isastraea bernardiana (d’Orbigny) in the uppermost Joyan Member; Bathonian ammonite Clydoniceras in the basal part of the Badabag Member; Bathonian foraminiferal/bivalve assemblages in the Fort Member. The topmost bed of the Joyan Member represents the peak of first marine transgression of the Jaisalmer Basin, probably contemporaneous with the Late Bajocian one in the neighbouring Kachchh Basin. Based on faunal studies Bajocian to Bathonian sediments of the Jaisalmer Basin can be broadly correlated with those of the Kachchh Basin. The Fort and Badabag members represent the following depositional environments, in chronological order: (a) brackish to shallow fully marine; (b) fully marine with rapidly fluctuating water energy and sedimentation rates; (c) near-shore to lower shoreface with fluctuating energy conditions, salinity and sedimentation rates; (d) near-shore to shoreface channels and storm-dominated marine above fair-weather wave-base; (e) lagoon with fluctuating low to moderate energy, salinity and sedimentation rates; (f) stormdominated shelf to lower shoreface. 相似文献
146.
中西方管理文化比较分析 总被引:4,自引:0,他引:4
贾冬莉 《科技情报开发与经济》2004,14(6):224-226
阐述了企业管理文化概念以及中西方管理文化的形成及其差异,通过中西方管理文化差异形成原因的分析,指出了社会上普遍存在的“中国企业的出路就是按照西方管理来运作”的认识的不合理性,得出“中国管理文化并不会被西方管理文化所取代”的结论,并借助海尔企业文化案例,提出了中国企业文化的发展方向。 相似文献
147.
韩德宏 《科技情报开发与经济》2004,14(6):83-84
在对山西省水资源开发利用所面临的问题进行剖析的基础上。提出了合理开发地下水资源、拉制水资源污染、发展节水工程和实行水资源的统一管理等科学、合理开发利用水资源的对策。 相似文献
148.
红豆杉细胞培养生产紫杉醇的研究进展 总被引:9,自引:0,他引:9
综述了近年来红豆杉细胞培养生产紫杉醇的研究进展, 包括红豆杉细胞培养生产紫杉醇的代谢调节、无机盐、植物生长调节因子、糖分及其它因素对红豆杉细胞生长和紫杉醇生产的影响等.着重介绍了前体饲喂、添加抑制剂和添加诱导子对红豆杉细胞生长及紫杉醇生产的影响. 相似文献
149.
As a newly developed precision technology, casting-forging complex near net forming process is utilized to produce complex components with a short lead time, low cost and high precision, thus to accelerate the response speed of the market and enhance the competitive power of products. In this paper, the casting-forging complex near net forming process of alternator claw pole was developed and investigated with a combination of experimental and numerical simulation method. Qualified near net workpiece was manufactured, mechanical parameter and relative field information during the forming process was also obtained. While the alternator claw-pole is processed with this technology, the forming force is small, the process is short and the quality of forgings is perfect. Therefore, the complex casting-forging near net forming process of claw-pole is an energy and material saving technology, which will have a vast developing and application prospect in the future. 相似文献
150.
Purification and cloning of amyloid precursor protein beta-secretase from human brain 总被引:40,自引:0,他引:40
Sinha S Anderson JP Barbour R Basi GS Caccavello R Davis D Doan M Dovey HF Frigon N Hong J Jacobson-Croak K Jewett N Keim P Knops J Lieberburg I Power M Tan H Tatsuno G Tung J Schenk D Seubert P Suomensaari SM Wang S Walker D Zhao J McConlogue L John V 《Nature》1999,402(6761):537-540
Proteolytic processing of the amyloid precursor protein (APP) generates amyloid beta (Abeta) peptide, which is thought to be causal for the pathology and subsequent cognitive decline in Alzheimer's disease. Cleavage by beta-secretase at the amino terminus of the Abeta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated carboxy-terminal fragment. Cleavage of the C-terminal fragment by gamma-secretase(s) leads to the formation of Abeta. The pathogenic mutation K670M671-->N670L671 at the beta-secretase cleavage site in APP, which was discovered in a Swedish family with familial Alzheimer's disease, leads to increased beta-secretase cleavage of the mutant substrate. Here we describe a membrane-bound enzyme activity that cleaves full-length APP at the beta-secretase cleavage site, and find it to be the predominant beta-cleavage activity in human brain. We have purified this enzyme activity to homogeneity from human brain using a new substrate analogue inhibitor of the enzyme activity, and show that the purified enzyme has all the properties predicted for beta-secretase. Cloning and expression of the enzyme reveals that human brain beta-secretase is a new membrane-bound aspartic proteinase. 相似文献