Cyclosporine is angiostatic

The systemic effect of the immunosuppressive drug cyclosporine (CS) on formation of new blood vessels was studied quantitatively in rats using the mesenteric-window assay. Angiogenesis was induced by i.p. injection of saline. CS at a s.c. dose of 4 mg/kg/day, which is in the range used clinically, suppressed angiogenesis (inhibiting branching or tortuosity more than spatial expansion), and appeared to be non-toxic. This is the first report on an apparently selective angiostatic effect of CS. The finding is likely to have implications for the clinical use of CS, not only in certain types of organ transplantation but possibly also in psoriasis and other angiogenesis-dependent diseases.     

地理学科在综合文科专业人才培养中的作用

高师综合文科教育专业是一门新兴的专业。地理、历史、政治学科在综合文科教育专业人才培养中,各自应发挥什么作用,这是专业建设和发展必须回答的重大理论问题。本文论述了地理学科在综合文科教育专业人才培养中的地位与作用。地理学科除了可为中学培养“历史与社会”课教师和地理教师外,还能够对学生进行地理素质教育、人文精神教育、环境教育、可持续发展教育和全球观念教育。     

重组pET30a/hsBLyS质粒在BL21(DE3)菌株中的稳定性观察

将构建的含有pET30a/hsBLyS重组质粒的BL21 (DE3)菌种,在含硫酸卡那霉素的平板培养基划线连续传代至 100代 100代次菌种经显微观察,为典型的革兰氏阴性大肠杆菌,生化特性没有改变 提取0、50、100代质粒DNA限制性内切酶切割检查,酶切图谱没有改变,DNA测序未见hsBLyS基因变异 传代前后菌种诱导表达hsBLyS,表达水平和hsBLyS生物学和免疫学活性均无明显差异     

关于简化Newton方法收敛性的注记

在假设算子方程解存在的前提下,给出了以解为中心的一个球域,证明了当初始点落到这个球域时,用于判断简化Newton方法收敛性的Kantorovich定理的条件必然满足,从而由简化Newton方法产生的迭代序列收敛.     

缩合型硅橡胶与金属的粘接研究

在以南大α系列硅烷偶联剂为基础的交联增粘体系中,引入某些γ系列硅烷偶联剂及增粘助剂,制成单组分室温硫化型粘合剂,并测定了其与铝、铜及不锈钢的粘接性能关系.研究表明:在既定的体系中加入KH-550、KH-792、WD-30以及KH-550与KH570的反应物可有效提高粘合剂对铝合金、黄铜及不锈钢的内聚破坏率,而且KH-550、KH-792还有助于改善粘合剂的贮存稳定性.     

异步DS-CDMA最优混沌序列集的性能分析

为了获得异步DS—CDMA系统的最优扩谱序列，给出了一套用来选取混沌二值序列的优化准则。基于这一优化准则，我们从Chebyshev映射生成的混沌序列中选取并构造出最优混沌二值序列集合。利用该集合作为异步DS-CDMA系统的扩谱序列，所得到的系统仿真结果符合最优扩谱序列的理论分析值，因此可以被认为是异步DS-CDMA系统的一个最优扩谱序列集合。     

数字图书馆发展与展望

介绍了网络时代数字图书馆的概念以及目前国内外数字图书馆的发展情况，展望了数字图书馆的发展趋势和未来。     

工时充值法在生产管理中的应用

根据企业生产管理的需要,创新性地总结出了“工时充值法”,并对工时充值法的指导思想、内容、适用范围、操作程序、意义、实际工作中应注意的问题等进行了诠释和探讨。     

Mutation of the matrix metalloproteinase 2 gene (MMP2) causes a multicentric osteolysis and arthritis syndrome.

The inherited osteolyses or 'vanishing bone' syndromes are a group of rare disorders of unknown etiology characterized by destruction and resorption of affected bones. The multicentric osteolyses are notable for interphalangeal joint erosions that mimic severe juvenile rheumatoid arthritis (OMIMs 166300, 259600, 259610 and 277950). We recently described an autosomal recessive form of multicentric osteolysis with carpal and tarsal resorption, crippling arthritic changes, marked osteoporosis, palmar and plantar subcutaneous nodules and distinctive facies in a number of consanguineous Saudi Arabian families. We localized the disease gene to 16q12-21 by using members of these families for a genome-wide search for homozygous-by-descent microsatellite markers. Haplotype analysis narrowed the critical region to a 1.2-cM region that spans the gene encoding MMP-2 (gelatinase A, collagenase type IV; (ref. 3). We detected no MMP2 enzymatic activity in the serum or fibroblasts of affected family members. We identified two family-specific homoallelic MMP2 mutations: R101H and Y244X. The nonsense mutation effects a deletion of the substrate-binding and catalytic sites and the fibronectin type II-like and hemopexin/TIMP2 binding domains. Based on molecular modeling, the missense mutation disrupts hydrogen bond formation within the highly conserved prodomain adjacent to the catalytic zinc ion.     

全球气候变化与塔里木盆地古城绿洲演变关系

我国西部地区地形复杂,气候的地域差异性大.特别是青藏高原的突起给塔里木盆地的环境带来了巨大的变化,导致盆地气温降水的突变.从而使塔里木盆地水流分布状态发生改变,导致盆地中原有的古绿洲的蜕变,进而直接影响到整个人类的发展历史.历史研究表明,塔里木盆地气候服从于全球气候变化,并且与某些人文事件,特别是古城绿洲兴盛与消亡有着十分一致的耦合关系.所以,全球环境变化对古城绿洲发展影响重大.