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排序方式: 共有173条查询结果,搜索用时 15 毫秒
11.
Vivek S. Peche Tad A. Holak Bhagyashri D. Burgute Kosmas Kosmas Sushant P. Kale F. Thomas Wunderlich Fatiha Elhamine Robert Stehle Gabriele Pfitzer Klaus Nohroudi Klaus Addicks Florian Stöckigt Jan W. Schrickel Julia Gallinger Michael Schleicher Angelika A. Noegel 《Cellular and molecular life sciences : CMLS》2013,70(3):527-543
Cyclase-associated proteins are highly conserved proteins that have a role in the regulation of actin dynamics. Higher eukaryotes have two isoforms, CAP1 and CAP2. To study the in vivo function of CAP2, we generated mice in which the CAP2 gene was inactivated by a gene-trap approach. Mutant mice showed a decrease in body weight and had a decreased survival rate. Further, they developed a severe cardiac defect marked by dilated cardiomyopathy (DCM) associated with drastic reduction in basal heart rate and prolongations in atrial and ventricular conduction times. Moreover, CAP2-deficient myofibrils exhibited reduced cooperativity of calcium-regulated force development. At the microscopic level, we observed disarrayed sarcomeres with development of fibrosis. We analyzed CAP2’s role in actin assembly and found that it sequesters G-actin and efficiently fragments filaments. This activity resides completely in its WASP homology domain. Thus CAP2 is an essential component of the myocardial sarcomere and is essential for physiological functioning of the cardiac system, and a deficiency leads to DCM and various cardiac defects. 相似文献
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J. A. Edgar M. Boppré D. Schneider 《Cellular and molecular life sciences : CMLS》1979,35(11):1447-1448
Summary 8 species of African and Australian danaid butterflies, captured in the field, were analyzed and found to contain pyrrolizidine alkaloids. It is suggested that these alkaloids, which are gathered by the adults from plants, contribute significantly to the chemical defences of the danaids. 相似文献
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L. Selmeci E. Pósch Julia Mosonyi L. Hársing 《Cellular and molecular life sciences : CMLS》1981,37(1):24-25
Summary Unilateral ureteral obstruction in rats, resulted in considerable alterations of polyamine levels in the obstructed kidney during a 72-h observation period, as compared with respective values for the contralateral control kidney.This work was supported in part by the Ministry of Health, Hungary (1-04-0301-03-02/H). The skilful technical assistance of Ms G. Mayer and Mrs I. Harmos is highly appreciated. 相似文献
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Peroxiredoxins are conserved markers of circadian rhythms 总被引:1,自引:0,他引:1
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