全文获取类型
收费全文 | 39057篇 |
免费 | 104篇 |
国内免费 | 192篇 |
专业分类
系统科学 | 202篇 |
丛书文集 | 650篇 |
教育与普及 | 70篇 |
理论与方法论 | 170篇 |
现状及发展 | 17888篇 |
研究方法 | 1591篇 |
综合类 | 18150篇 |
自然研究 | 632篇 |
出版年
2013年 | 331篇 |
2012年 | 549篇 |
2011年 | 1177篇 |
2010年 | 243篇 |
2008年 | 717篇 |
2007年 | 760篇 |
2006年 | 767篇 |
2005年 | 735篇 |
2004年 | 748篇 |
2003年 | 674篇 |
2002年 | 671篇 |
2001年 | 1154篇 |
2000年 | 1082篇 |
1999年 | 763篇 |
1992年 | 744篇 |
1991年 | 530篇 |
1990年 | 598篇 |
1989年 | 612篇 |
1988年 | 591篇 |
1987年 | 653篇 |
1986年 | 592篇 |
1985年 | 785篇 |
1984年 | 622篇 |
1983年 | 477篇 |
1982年 | 444篇 |
1981年 | 468篇 |
1980年 | 580篇 |
1979年 | 1166篇 |
1978年 | 981篇 |
1977年 | 953篇 |
1976年 | 808篇 |
1975年 | 842篇 |
1974年 | 1129篇 |
1973年 | 1019篇 |
1972年 | 1054篇 |
1971年 | 1157篇 |
1970年 | 1468篇 |
1969年 | 1178篇 |
1968年 | 1175篇 |
1967年 | 1137篇 |
1966年 | 977篇 |
1965年 | 693篇 |
1964年 | 233篇 |
1959年 | 388篇 |
1958年 | 679篇 |
1957年 | 457篇 |
1956年 | 403篇 |
1955年 | 368篇 |
1954年 | 395篇 |
1948年 | 285篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
951.
The purpose of this study was to determine whether the western rattlesnake ( Crotalus viridis ) aims its predatory strike at the head/thorax region of mice primarily on the basis of cues related to the direction of prey movement. We hypothesized that when rattlesnakes strike at anesthetized, backward-moving mice, most strikes would be aimed at the forward-most-moving region, i.e., the posterior (abdomen/tail) region of prey. However, most mice were struck in the anterior (head/thorax) region, implying that the visual-infrared image of mice, rather than directional movement, guides the aim of predatory strikes. 相似文献
952.
953.
The activation of ubiquitin and related protein modifiers is catalysed by members of the E1 enzyme family that use ATP for the covalent self-attachment of the modifiers to a conserved cysteine. The Escherichia coli proteins MoeB and MoaD are involved in molybdenum cofactor (Moco) biosynthesis, an evolutionarily conserved pathway. The MoeB- and E1-catalysed reactions are mechanistically similar, and despite a lack of sequence similarity, MoaD and ubiquitin display the same fold including a conserved carboxy-terminal Gly-Gly motif. Similar to the E1 enzymes, MoeB activates the C terminus of MoaD to form an acyl-adenylate. Subsequently, a sulphurtransferase converts the MoaD acyl-adenylate to a thiocarboxylate that acts as the sulphur donor during Moco biosynthesis. These findings suggest that ubiquitin and E1 are derived from two ancestral genes closely related to moaD and moeB. Here we present the crystal structures of the MoeB-MoaD complex in its apo, ATP-bound, and MoaD-adenylate forms, and highlight the functional similarities between the MoeB- and E1-substrate complexes. These structures provide a molecular framework for understanding the activation of ubiquitin, Rub, SUMO and the sulphur incorporation step during Moco and thiamine biosynthesis. 相似文献
954.
Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} Carebareia, n. gen., and its type - species, C. johnstoni, n. sp., are described. The genus Quadraseta Brennan, 1970, is redefined and a key to the 11 included species given. Four new species, Quadraseta tachirensis, holotype ex Akodon sp., Q. rotstieri, ex Proechimys guyannensis, Q. mirandae, holotype ex Oryzomys albigularis, and Q. falconensis, ex Sylvilagus floridanus, are described. 相似文献
955.
Richard L. Wallace J. S. Griffith Jr. D. M. Daley Patrick J. Connolly G. B. Beckham 《西北部美国博物学家》2011,44(2)
Cottus greenei, a potentially threatened species endemic to Idaho, was collected from 49 localities in 25 springs/streams in south central Idaho. Most localities were along the north bank of the Snake River in waters of the Thousand Springs formation, Gooding County. One population was found in a spring in the main Snake River. Another sculpin, Cottus bairdi, was collected with C. greenei at 23 locations in 16 springs/streams. Confusion concerning the type locality of Cottus greenei is discussed. 相似文献
956.
L. Vanderkelen J. M. Van Herreweghe K. G. A. Vanoirbeek G. Baggerman B. Myrnes P. J. Declerck I. W. Nilsen C. W. Michiels L. Callewaert 《Cellular and molecular life sciences : CMLS》2011,68(6):1053-1064
Lysozymes are antibacterial effectors of the innate immune system in animals that hydrolyze peptidoglycan. Bacteria have evolved
protective mechanisms that contribute to lysozyme tolerance such as the production of lysozyme inhibitors, but only inhibitors
of chicken (c-) and invertebrate (i-) type lysozyme have been identified. We here report the discovery of a novel Escherichia coli inhibitor specific for goose (g-) type lysozymes, which we designate PliG (periplasmic lysozyme inhibitor of g-type lysozyme).
Although it does not inhibit c- or i-type lysozymes, PliG shares a structural sequence motif with the previously described
PliI and MliC/PliC lysozyme inhibitor families, suggesting a common ancestry and mode of action. Deletion of pliG increased the sensitivity of E. coli to g-type lysozyme. The existence of inhibitors against all major types of animal lysozyme and their contribution to lysozyme
tolerance suggest that lysozyme inhibitors may play a role in bacterial interactions with animal hosts. 相似文献
957.
Nam Q Nguyen Laura K Bryant Carly M Burgstad Robert J Fraser Daniel Sifrim Richard H Holloway 《河南科技》2010,(3)
AIM: To assess the impact of bolus volume on the characteristics of small intestinal (SI) impedance signals.METHODS: Concurrent SI manometry-impedance measurements were performed on 12 healthy volunteers to assess the pattern of proximal jejunal fluid bolus movement over a 14 cm-segment.Each subject was given 34 boluses of normal saline (volume from 1 to 30 mL) via the feeding tube placed immediately above the proximal margin of the studied segment.A bolus-induced impedance event occurred if there was > 12%... 相似文献
958.
G. E. Callander R. A. D. Bathgate 《Cellular and molecular life sciences : CMLS》2010,67(14):2327-2341
Since its discovery in the 1920s, relaxin has enjoyed a reputation as a peptide hormone of pregnancy. However, relaxin and
other relaxin family peptides are now associated with numerous non-reproductive physiologies and disease states. The new millennium
bought with it the sequence of the human genome and subsequently new directions for relaxin research. In 2002, the ancestral
relaxin gene RLN3 was identified from genome databases. The relaxin-3 peptide is highly expressed in a small region of the brain and in species
from teleost to primates and has both conserved sequence and sites of expression. Combined with the discovery of the relaxin
family peptide receptors, interest in the role of the relaxin family peptides in the central nervous system has been reignited.
This review explores the relaxin family peptides that are expressed in or act upon the brain, the receptors that mediate their
actions, and what is currently known of their functions. 相似文献
959.
Ponderosa pine cones from 10 areas in Arizona were collected prior to natural seed dispersal and dissected to determine the number of sound, hollow, and insect-damaged seeds in each cone. Total and sound seed yields per cone did not vary significantly among areas but did vary significantly among trees within each area. Numbers of hollow and Megastigmus -infested (Hymenoptera: Torymidae) seeds varied significantly among areas and trees within areas. Numbers of sound seed increased significantly with increasing cone length but did not change with increasing numbers of cones per cluster. The percentages of Megastigmus -infested seed did not change significantly with increasing cone length or number of cones per cluster. 相似文献
960.
Dorald M. Allred 《西北部美国博物学家》2011,40(2)
A bite by Chiracanthium mildei L. Koch is described. 相似文献