A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis

To identify susceptibility loci for ankylosing spondylitis, we performed a two-stage genome-wide association study in Han Chinese. In the discovery stage, we analyzed 1,356,350 autosomal SNPs in 1,837 individuals with ankylosing spondylitis and 4,231 controls; in the validation stage, we analyzed 30 suggestive SNPs in an additional 2,100 affected individuals and 3,496 controls. We identified two new susceptibility loci between EDIL3 and HAPLN1 at 5q14.3 (rs4552569; P = 8.77 × 10(-10)) and within ANO6 at 12q12 (rs17095830; P = 1.63 × 10(-8)). We also confirmed previously reported associations in Europeans within the major histocompatibility complex (MHC) region (top SNP, rs13202464; P < 5 × 10(-324)) and at 2p15 (rs10865331; P = 1.98 × 10(-8)). We show that rs13202464 within the MHC region mainly represents the risk effect of HLA-B*27 variants (including HLA-B*2704, HLA-B*2705 and HLA-B*2715) in Chinese. The two newly discovered loci implicate genes related to bone formation and cartilage development, suggesting their potential involvement in the etiology of ankylosing spondylitis.     

Transient receptor potential canonical channels in angiogenesis and axon guidance

Wiring of vascular and neural networks requires precise guidance of growing blood vessels and axons, respectively, to reach their targets during development. Both of the processes share common molecular signaling pathways. Transient receptor potential canonical (TRPC) channels are calcium-permeable cation channels and gated via receptor- or store-operated mechanisms. Recent studies have revealed the requirement of TRPC channels in mediating guidance cue-induced calcium influx and their essential roles in regulating axon navigation and angiogenesis. Dissecting TRPC functions in these physiological processes may provide therapeutic implications for suppressing pathological angiogenesis and improving nerve regeneration.     

耗能连梁采用新型复合阻尼器后对剪力墙结构性能的影响

研究一种震后可替换的新型复合阻尼器置于连梁跨中以实现保护连梁并提高连梁耗能能力的目标.在ABAQUS有限元软件平台上根据复合阻尼器的特点提出一种可以有效反映其特征的等效简化模型,并与仿真模型进行对比验证;将等效简化模型应用于高层剪力墙结构的连梁中,进行罕遇地震下的剪力墙结构动力时程分析;以混凝土连梁为参照,研究安装了复...     

高弹性合金Cu-Ni-Sn的研究与发展

阐述了Cu-Ni-Sn合金依靠其良好的力学性能和环保等特点,作为一种有望替代铍青铜的新型铜基弹性合金,被广泛应用于制作各种接插件、弹簧件和开关等弹性元件.文章介绍了该合金国内外研究现状和制备工艺,分析了Ti、Si、Cr、Al、Co、Fe、In和Mn等元素对合金组织和性能的影响,指出了Cu-Ni-Sn合金未来研究的重点应集中在降低合金偏析程度、优化加工工艺和添加适当微量元素提升其性能等方面.     

动车组车体底边梁用6005A铝型材检验分析

6005A铝合金大截面复杂制品作为轨道车体的边梁或枕梁,对轨道车体的整体起连接和承重作用,是动车组车体的关键部位。采用电子万能试验机、铝型材压力试验机、光学显微镜等研究了速度达400 km·h^-1动车组车体底边梁用6005A铝型材的强度、显微组织和断口形貌等,旨在为动车组用铝挤压型材产品检验和工艺制度制定提供技术支持与指导。     

Ti-1300钛合金挤压管材组织性能研究

通过室温拉伸测试和显微组织观察,研究了挤压温度和热处理工艺对Ti-1300钛合金挤压管材显微组织和力学性能的影响,讨论了热加工工艺、显微组织和力学性能之间的关系。结果表明：Ti-1300钛合金在两相区挤压后的横向组织均匀细小,纵向组织沿挤压加工流线破碎均匀;其拉伸强度高达1 445 MPa。管材在相变点以上的高温固溶组织主要由等轴β相晶粒组成,具有较好的塑性。合金两相区挤压后具有较好的强度和塑性的匹配,两相区挤压的塑性明显优于β单相区挤压,尤其面缩。试样经过固溶时效处理后显微组织明显细化,强度大幅度提高,可达1 300 MPa以上。     

离子交换色谱柱上橙皮苷分离与配位反应的一体化

提出并实现了橙皮苷分离及其与Cu2 配位反应一体化的新设想,并借助离子交换色谱、紫外可见光谱、X-射线衍射、傅立叶红外光谱和核磁共振等分析手段探讨其作用机理.结果表明,在离子交换色谱柱上能有效实现配体分离与配位反应的一体化,制备高生物活性中药配合物新药.其反应机理在于树脂相中软碱橙皮苷与溶液相中交界酸Cu2 间存在库仑力,容易发生配位反应,配体的分子状态和疏水状态因Cu2 对橙皮素的"集中效应"和芸香二糖对橙皮素的"包埋效应"而改变,故再生剂阴离子易穿过能斯特层与橙皮苷交换,并因电子云重叠而排斥橙皮苷至液相中,从而有助于分离、反应一体化.