一类奇异微分方程边值问题的数值方法

在再生核空间中讨论一类二阶奇异微分方程两点边值问题.研究方程解存在的充分性和解唯一的必要性,建立解的精确表达式,获得近似解的求解方法,数值模拟结果说明该方法的有效性.     

多目标规划纯量化问题的Lipschitz稳定性

利用Kojima函数的正则性质研究了多目标规划问题的纯量化问题解的强Lipschitz稳定性．     

木果楝挥发油成分的GC-MS分析

采用气相色谱-质谱联用技术,首次对木果楝叶子和果实挥发油进行了成分分析,从木果楝叶子和果实分别鉴定出了33和36种化合物,分别占挥发油的99.11%和97.63%.两个部位中挥发油化学组成各有异同,但其主要成分均是倍半萜类化合物b-桉叶烯和γ-桉叶烯.本研究结果可为木果楝的综合开发利用提供理论依据.     

国家自然科学基金3+X同行评议方式的初步探讨

本文通过对植物学科2003、2004年度自由申请项目的同行评议结果随机抽样进行统计处理,并结合2005、2006年度3位专家的实际评议情况,初步探讨了3位专家评议结果与5位专家评议结果对比的变化规律及植物学科今后如何针对3位专家评议后的结果进行" X"(1或2位专家)选择的具体做法。     

股票市场普适性规律的分析与研究

分析了国内外许多学者近年来对不同国家或地区股票市场波动规律的研究,提出了股票市场存在普适性,并论述了普适性在收益的概率分布、波动率的变化规律和收益的多重分形分布中的存在,为进一步研究股票市场波动的动力学规律提供了依据.     

Synthesis and characterization of bifunctional terbium complex-based nanoparticles

Novel bifunctional terbium complex-based nanoparticles were developed using a modified Stber method and a layer-by-layer assembly process. A magnetic core of Fe3O4 nanoparticles was coated with a silica shell to form the first layer. Then a ternary Tb3+ complex (TESPPA-Tb), which acted as a luminescent marker, was covalently bound to the silica surface by stable Si-O-Si bonds. The TESPPA monomer was synthesized by binding pyridine 2,6-dicarboxylic acid to 3-aminopropyltriethoxysilane, which was used as a ligand for coordination with the Tb3+ ions. An outer shell of silica was applied to the nanoparticles to allow for versatility with surface functionalization. The nanoparticles were characterized by X-ray powder diffraction, transmission electron microscopy, Fourier transform infrared spectroscopy, ultravioletvisible spectroscopy, vibration sample magnetometer, and photoluminescence spectroscopy. The bifunctional nanoparticles exhibited favorable superparamagnetic behavior and photoluminescence properties of Tb3+. These nanoparticles have potential applications in biolabeling, bioseparation, immunoassays, and pathogenic diagnosis.     

Electromagnetic modification of faceted-faceted Ni<Subscript>31</Subscript>Si<Subscript>12</Subscript>-Ni<Subscript>2</Subscript>Si eutectic alloy

In an electromagnetic field, the morphology of a binary faceted-faceted (FF) Ni31Si12-Ni2Si eutectic microstructure and the alloy’s mechanical properties were investigated. Hardness experiments demonstrated that the solidified ingots were significantly strengthened, and the hardness was improved to 63.1 and 786.6 on the Rockwell hardness C and Vickers hardness scales, respectively. Tests of friction and wear in stirred FF eutectic alloys showed excellent anti-fatigue and anti-adhesion wear performance. Alloy changed from an anomalous microstructure to a refined quasi-regular structure, and there was an increase in the lamellar microstructure fraction. The formation process of the refined quasi-regular microstructure and the resulting mechanical properties were investigated.     

Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

Drug resistance presents a challenge to the treatment of cancer patients. Many studies have focused on cell-autonomous mechanisms of drug resistance. By contrast, we proposed that the tumour micro-environment confers innate resistance to therapy. Here we developed a co-culture system to systematically assay the ability of 23 stromal cell types to influence the innate resistance of 45 cancer cell lines to 35 anticancer drugs. We found that stroma-mediated resistance is common, particularly to targeted agents. We characterized further the stroma-mediated resistance of BRAF-mutant melanoma to RAF inhibitors because most patients with this type of cancer show some degree of innate resistance. Proteomic analysis showed that stromal cell secretion of hepatocyte growth factor (HGF) resulted in activation of the HGF receptor MET, reactivation of the mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-OH kinase (PI(3)K)-AKT signalling pathways, and immediate resistance to RAF inhibition. Immunohistochemistry experiments confirmed stromal cell expression of HGF in patients with BRAF-mutant melanoma and showed a significant correlation between HGF expression by stromal cells and innate resistance to RAF inhibitor treatment. Dual inhibition of RAF and either HGF or MET resulted in reversal of drug resistance, suggesting RAF plus HGF or MET inhibitory combination therapy as a potential therapeutic strategy for BRAF-mutant melanoma. A similar resistance mechanism was uncovered in a subset of BRAF-mutant colorectal and glioblastoma cell lines. More generally, this study indicates that the systematic dissection of interactions between tumours and their micro-environment can uncover important mechanisms underlying drug resistance.     

戈塘矿区层滑构造研究

戈塘金矿存在多层次层滑动构造系统，其主滑面位于茅口灰岩之上的岩溶不整合面上，矿区内不同构造层的变形型式，变形强度差异很大，变形不协调，强硬岩层以脆性变形为主，软弱层则以塑性变形的为特征，对矿区内层滑构造的研究可以从一个侧面揭示戈塘金矿的成因并进而指导找矿。     

复合滤池-人工湿地组合工艺对城市高污染水的处理

采用复合滤池-人工湿地组合工艺处理城市高污染水,考察了组合工艺对污染物的去除效果及稳定性的影响。结果表明,有机物的降解和硝化主要在滤池中完成,氮、磷则通过人工湿地进一步去除。温度的季节性变化对磷的去除效果有少许影响,碳源不足限制了脱氮效果,组合工艺对污染物的处理效果稳定,出水中COD、TP、NH4+-N、TN平均质量浓度分别为16.39、0.38、1.44、16.38 mg/L,出水水质可达到城市杂用水水质标准。