建国初期党对私营文化事业的改造与管理——从陋俗文化改造的视角

建国初期,私营文化事业在一定时期内满足了人民群众对精神文化的需求,但同时也成为陋俗文化得以蔓延的土壤。党和政府对私营文化事业的政策经历了由扶植到改造的变迁。在这一政策的指导下,我国顺利完成了对私营文化的社会主义改造,为党和政府开展对陋俗文化的改造提供了良好的社会条件。对这段历史进行梳理,对于当前正确处理发展国有文化事业与民营文化事业的关系具有重要的启示。     

过度自信委托代理人间的薪酬合同研究

委托-代理模型中，委托人委托代理人销售产品并付给代理人一定的报酬. 委托人和代理人对随机需求的均值或方差的估计存在误差，由此产生绝对过度自信和相对过度自信. 委托人可提供的薪酬合同有两种：线性合同和阈值合同. 在委托人和代理人持有的不同自信度组合中，分别给出了线性合同和阈值合同下的最优参数. 研究得出：对委托人而言，当且仅当其关于不确定性需求方差的信念较代理人悲观，并且对市场需求位于零点附近的可能性的估计较代理人小时，阈值合同优于线性合同；否则，在线性合同和阈值合同下，委托人的均衡期望收益相等.     

Melatonin transport into mitochondria

Melatonin is a well-known, nighttime-produced indole found in bacteria, eukaryotic unicellulars, animals or vascular plants. In vertebrates, melatonin is the major product of the pineal gland, which accounts for its increase in serum during the dark phase, but it is also produced by many other organs and cell types. Such a wide distribution is consistent with its multiple and well-described functions which include from the circadian regulation and adaptation to seasonal variations to immunomodulatory and oncostatic actions in different types of tumors. The discovery of its antioxidant properties in the early 1990s opened a new field of potential protective functions in multiple tissues. A special mention should be made regarding the nervous system, where the indole is considered a major neuroprotector. Furthermore, mitochondria appear as one of the most important targets for the indole’s protective actions. Melatonin’s mechanisms of action vary from the direct molecular interaction with free radicals (free radical scavenger) to the binding to membrane (MLT1A and MLT1B) or nuclear receptors (RZR/RORα). Receptor binding has been associated with some, but not all of the indole functions reported to date. Recently, two new mechanisms of cellular uptake involving the facilitative glucose transporters GLUT/SLC2A and the proton-driven oligopeptide transporter PEPT1/2 have been reported. Here we discuss the potential importance that these newly discovered transport systems could have in determining the actions of melatonin, particularly in the mitochondria. We also argue the relative importance of passive diffusion vs active transport in different parts of the cell.     

Products Ranking Through Aspect-Based Sentiment Analysis of Online Heterogeneous Reviews

With the rapid growth of online shopping platforms, more and more customers intend to share their shopping experience and product reviews on the Internet. Both large quantity and various forms of online reviews bring difficulties for potential consumers to summary all the heterogenous reviews for reference. This paper proposes a new ranking method through online reviews based on different aspects of the alternative products, which combines both objective and subjective sentiment values. Firstly, weights of these aspects are determined with LDA topic model to calculate the objective sentiment value of the product. During this process, the realistic meaning of each aspect is also summarized. Then, consumers’ personalized preferences are taken into consideration while calculating total scores of alternative products. Meanwhile, comparative superiority between every two products also contributes to their final scores. Therefore, a directed graph model is constructed and the final score of each product is computed by improved PageRank algorithm. Finally, a case study is given to illustrate the feasibility and effectiveness of the proposed method. The result demonstrates that while considering only objective sentiment values of the product, the ranking result obtained by our proposed method has a strong correlation with the actual sales orders. On the other hand, if consumers express subjective preferences towards a certain aspect, the final ranking is also consistent with the actual performance of alternative products. It provides a new research idea for online customer review mining and personalized recommendation.     

河南省产业转移的创新响应区际差异研究

以产业转移的创新响应系数作为测度产业转移创新响应强度的变量指标,根据标准差和变异系数、相对发展率(Nich)以及离差(Di)和比率(Gi)等方法分析了河南省产业转移创新响应强度的区际差异及其影响因素。结果发现:(1)2007—2015年河南省产业转移的创新响应强度呈现不断增大的态势并呈现出阶段变化的特征。(2)河南省产业转移的创新响应强度从静态格局和动态变化上都呈现出明显的时空差异性,并根据各市的区域特点及产业转移的创新响应强度将河南省18个地市划分为强、较强、中等、较弱以及弱等5种区域类型;(3)创新能力、人才密集度、科技投入对产业转移的创新效应作用较大,技术市场需求和信息化作用相对较小。     

基于电刺激的多模式康复系统设计和研究

针对脑卒中后肢体功能障碍、褥疮及疼痛,分析了临床上常用的治疗参数,设计了多模式电刺激治疗系统。该系统通过触摸屏与主芯片STM32L152RCT6进行通信,控制升压和极性转换电路产生幅值、频率及脉宽均可连续调节的双极性电刺激脉冲,验证了系统的稳定性和镇痛的效果。通过试验验证了系统能稳定工作,且电脉冲幅值与电阻值的变化无关,且能提高受试者的疼痛阈值。能产生临床使用的电刺激疗法的各类参数,有利于临床实验和相关科研的开展。电刺激技术能够缓解人体疼痛,提高疼痛阈值。     

基于正态分布概率模型的渗滤液回灌影响分析

渗滤液回灌能有效加速填埋场的稳定并处理多余的渗滤液, 而预测回灌过程中渗滤液的运移规律对于合理设置回灌井的间距和数量具有重要的意义. 考虑了垃圾体的非均质性, 建立了垃圾体的渗透系数随空间正态分布变化的概率模型. 利用 COMSOL Multiphysics^® 软件, 首先对单孔隙度的横纵向均质模型和正态分布模型的 渗透系数以及压力水头进行了比较, 其次研究了在横纵向渗透系数比值、回灌速率和回灌时间等不同 影响因素下, 均质模型和正态分布模型的含水率以及横向影响范围的变化规律. 结果表明, 随着横纵向渗透系数比值的增加, 最终在 100 d 时: 均质模型的含水率由 0.609 增加到 0.68, 横向影响范围从4.842 m 增加到 6.79 m; 正态分布模型的含水率由 0.573 增加到 0.610, 横向影响范围从4.097 m 变为 4.04 m. 这说明横纵向渗透系数比值对正态分布模型的含水 率和渗滤液横向影响范围的影响明显高于均质模型. 而当回灌速率和回灌时间相同时, 正态分布模型渗滤液的渗流速度更快, 易于优先达到饱和含水率, 并在短暂的峰值后迅速下降, 且随着回灌速率和回灌时间的增加, 达到饱和含水率和峰值的时间也逐渐增加.     

基于高效液相色谱法的牛黄解毒制剂中胆红素含量测定

利用高效液相色谱法建立牛黄解毒制剂中胆红素的含量测定方法,色谱柱为Agilent Zorbax SB-C18色谱柱,流动相为乙腈—1%冰醋酸(95∶5),检测波长为450 nm.结果显示,胆红素进样量在0.8321~208.032 ng范围内具有良好的线性关系,r=0.9995,牛黄解毒片平均回收率为105.6%,RSD为1.42%,牛黄解毒丸平均回收率为96.2%,RSD为1.83%.结果表明,方法准确、简便,可作为牛黄解毒片及牛黄解毒丸等制剂中胆红素含量的测定方法.