Induction of multi-epitopespecific antibodies against HIV-1 by multi-epitopevaccines

Some neutralizing antibodies against HIV-1 envelope proteins were highly effective to inhibit the infection of different strainsin vitro, and existed in the infected individuals with very low levels. We suggested multi-epitope-vaccine as a new strategy to increase levels of neutralizing antibodies and the abilities against HIV mutationin vivo. Two candidate multi-epitope-vaccines induced antibodies with predefined multi-epitope-specificity in rhesus macaque. These antibodies recognized corresponding neutralizing epitopes on epitope-peptides, gp41 peptides, V3 loop peptide, rsgp41 and rgp120. Besides, three candidate epitope-vaccines in combination (another kind of multi-epitopevaccines) showed similar potency to induce predefined multiple immune responses in rabbits. These results suggest that multi-epitope-vaccines may be a new strategy to induce multi-antiviral activities against HIV-1 infection and mutations.     

Ground settlement of Chek Lap Kok Airport, Hong Kong, detected by satellite synthetic aperture radar interferometry

Satellite synthetic aperture radar (SAR) interferometry is used to investigate the slowly accumulating ground settlement at the new Chek Lap Kok Airport in Hong Kong. Most of the land occupied by the airport was reclaimed from the sea and therefore certain ground settlement in the area has been expected. A pair of ERS-2 SAR images spanning nearly a year is used in the study. The high spatial resolution (20 mx20 m) ground settlement map derived indicates that the settlement that occurred in the area over the time period is as large as 50 mm. The SAR measurement results agree with the levelling measurements at some benchmarks in the area to well within 1 cm(rms error), and the overall correlation between the two types of results is 0.89. The paper presents some brief background of interferometric SAR, and outlines the data processing methods and results.     

Sex-related gene and sex identification of Crested IbisNipponia nippon (Ciconiiformes: Threskiornithidae)

The Crested Ibis (Nipponia nippon) is a critical endangered species of the world. At present, a reintroduction program will be conducted to save this species essentially. However, because the Crested Ibise is a sexual alike bird, it is very difficult to identify the sex from the morphological character. In order to identify the sex easily and select the right individuals for captive breeding and reintroduction, the sex related gene on W chromosome was amplified and the sex of three Crested Ibises were also identified in the present study. The 262bp fragment was also sequenced, and we found that there were 13 different nucleotide sites with 2.25 of transition/transversion based on the comparison with that of the Oriental White Stork. The sequence will also provide a theoretic base for further designing specific primer for sex related gene in the Crested Ibis.     

TS求解多机成组工件调度

讨论并行多机成组工件的极小化最大通过时间调度问题·它是一个非常复杂的组合优化问题,是NP难题·为了解决此类问题,采用了两种智能优化算法方法·通过大量的仿真实验,将两种方法进行了比较·结果证明:禁忌搜索结合启发式的智能优化算法可靠性高、运算速度快,有能力有效地解决大规模实际问题·     

略谈藏医学的饮食养生

本就西藏医学发展史上,人们对饮食养生的认识为出发点,就不同季节的食养和食养与饮食卫生进行了探讨。并结合现代医学和养生理论作了论述,使人们对饮食养生在增进人体健康方面有一较为科学的认识。     

面向对象的土地定级特征模型

采用面向对象技术的特征建模方法,通过建立土地定级的特征对象模型、特征字典模型、作用分值计算模型和定级的数据库模型,不但集成了定级因素来自几何和非几何两方面的信息,数据得到更有效的组织,数据完整性也更易于维护,而且不同土地用途类型的定级数据可混合处理,用地类型可变,系统的开放性得到保证,面向对象技术的应用不但提高了系统的通用性和可复用性,而且简化了作用分值的计算过程,提高了计算效率。该模型应用于“宗地评估与地价查询系统”的研究开发和实践,优越性显著。     

沥青混合料动态模量试验的仿真和验证

为了能对沥青混合料单轴压缩动态模量试验进行合理的仿真,文章建立了可表征骨料截面真实形态的四相体数值试件和虚拟加载试验.通过对大量的骨料截面轮廓进行分形维数的统计分析,得到该指标的正态分布规律,并结合中点位移法重构数值试件所需的骨料截面.基于柱坐标系的特征,将圆柱形试件转化为二维试件.基于瓦拉文公式,获得对应于Fulle...     

连栽杉木人工林生产力的模拟与预测

应用森林生态系统管理与预测模型（ＦＯＲＴＯＯＮ）对连栽杉木人工林不同经营措施进行模拟。通过对结果的对比分析表明,三代连栽的杉木林在生物量和立地质量方面呈逐代下降的趋势;选用下层疏伐法对林分生长较有利;施用有机肥效果明显,可以迅速提高林地有效养分含量和林分生物量;清除枯落物会明显降低林分生物量。模拟结果与实际情况比较相符,证明了模型的有效性,可作为进一步模拟研究的基础,以便得到一个最佳的经营方案,为     

Geologic relationships and geochronology of the Cenozoic volcanoes and interbedded weathered mantles of Yulinshan in Qiangtang, North Tibet

The Yulinshan accumulations of volcanic rocks and interbedded weathered mantles provide a unique chance for studying the processes and environment of the formation of the planation surface in central Tibetan Plateau. Geochemical,⁴⁰Ar/³⁹Ar and K/Ar geochronologic investigations of the weathered mantles and high-potassium volcanic rocks reveal that the volcano-weathered mantle accumulations formed under arid or semi-arid subtropic environment in 30–24 Ma. The sole planation surface of the Qiangtang region finally formed in about 20 Ma.     

Orogen-parallel extension in Himalays:Is it the indicator of collapse or the product in process of compressive uplift?

Extensional structures developed extensively in Himalaya with their strikes perpendicular to that of the orogenic belt. The studies of such structures in Qusum, Burang, Lhozhag, Nyalam and Yadong show that they represent an orogen-parallel extension. The basins produced by the extension experienced orogen-perpendicular compression during their formation. The ages of the extension rang from 16 to 13 Ma and coincide with the intensive compressive stage in Southeastern Asia. Therefore, the extension is syn-shortening and the dominate tectonic movement in Himalaya was compression and uplift during the extension. The extension was the partition of compressive deformation rather than the indicator for the collapse and falling of the Tibetan Plateau.