Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly but reproducibly influence risk of type 2 diabetes (T2D). Established associations to common and rare variants explain only a small proportion of the heritability of T2D. As previously published analyses had limited power to identify variants with modest effects, we carried out meta-analysis of three T2D GWA scans comprising 10,128 individuals of European descent and approximately 2.2 million SNPs (directly genotyped and imputed), followed by replication testing in an independent sample with an effective sample size of up to 53,975. We detected at least six previously unknown loci with robust evidence for association, including the JAZF1 (P = 5.0 x 10(-14)), CDC123-CAMK1D (P = 1.2 x 10(-10)), TSPAN8-LGR5 (P = 1.1 x 10(-9)), THADA (P = 1.1 x 10(-9)), ADAMTS9 (P = 1.2 x 10(-8)) and NOTCH2 (P = 4.1 x 10(-8)) gene regions. Our results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D.     

参数辨识法对半实物仿真系统进行精度分析

仿真精度是国内外系统仿真工作者正在进行研究的课题。以现有的红外制导空间半实物仿真系统为对象进行精度分析,首先采用参数辨识法建立各仿真设备的精确数学模型,然后对一种具体产品的制导回路进行数学仿真,把数学仿真结果与各仿真设备模型加入后的数学仿真结果进行比较,定量地得出了各仿真设备影响的结果,最后,对各仿真设备影响的误差结果进行了置信度计算及分析。     

A Method on Non-Linear Correction of Broadband LFMCW Signal Utilizing Its Relative Sweep Non-Linear Error

1. INTaODUCTIONLinear frequency modulation continuous wave (LFMCW) radar with broadband has a high range Precisinlland high resollltion because of its large time bandwidth product and has no blind range at the'sarne take.LFMCW radax has more extensive applications in many fields such as microwave ranging, crashworthy car, andmissile's terminal guidance because broadband LFMCW devices are being miniaturized and integrated with therapid developmellt of microwave and millimeter wave ill…     

能量存储:基于全新原理的“纳米弹簧”

许多机械装置如钟表、玩具等都采用弹簧来驱动,其能量的存储与释放是通过弹簧内部原子间距的变化来实现的。但是这种原子间距的变化(即弹性变形)所能存储的体能量密度相对很低,如何提高能量的转换效率以及材料存储的能量密度是当前材料科学理论和实验研究共同关注的一个问题。本研究利用金属钨单晶纳米线在加载时独特的孪晶变形行为,提出了一个可以在纳米尺度下高效存储与释放机械能的新原理,并据此设计了相应的纳米装置——纳米弹簧。与块体弹簧不同,本文提出的纳米弹簧通过表面原子的重构来实现能量的存储与释放。进一步的计算还表明,由于金属钨孪晶界面的移动阻力非常小,金属钨纳米弹簧的能量转换效率可以达到98%;同时该纳米弹簧存储的体能量密度可以超过钟表发条的1600倍,并具有30%的应变以及3GPa的驱动应力。     

HSLWAC梁收缩和徐变预应力损失试验

对5根高强轻骨料混凝土梁、1根低强轻骨料混凝土梁和1根普通混凝土梁进行了持续1年的预应力损失试验,并进行了与普通混凝土对比的收缩和徐变材性试验.试验结果表明,相同强度的轻骨料混凝土的早期收缩小于普通混凝土,后期收缩大于普通混凝土;相同强度的轻骨料混凝土徐变系数小于普通混凝土;轻骨料混凝土梁的预应力损失比普通混凝土梁的预应力损失大.结合编制的混凝土结构时随性能分析程序,基于材料收缩徐变试验进行分析,计算结果与试验结果吻合较好.采用多种规范方法对所做试验和文献的预应力损失进行了分析对比,建议了高强轻骨料混凝土梁预应力损失计算公式.     

灰色关联度在甜高粱材料筛选中的应用

对甘肃省兰州市榆中县中试基地种植的11种甜高粱材料进行试验,以筛选出适合在兰州榆中地区种植的甜高粱材料。采用灰色关联度对材料的茎干鲜重、生物产量、茎杆平均含糖量进行分析,同时参考株高、穗长、穗颈长、物候期等指标,选定适合榆中地区不同用途的甜高粱材料。灰色关联度分析结果:茎秆鲜重、生物产量、茎秆平均含糖量三个指标中,茎秆平均含糖量灰色关联度最大,对结果影响最大;灰色综合评判排序显示08-2、2043、09-1、雅津43号分别排列前4位。08-2、2043、09-1、雅津43号综合表现最好,适合兰州榆中地区种植,可用于饲料生产和生物质能源储备种植。     

单质对低碳钢A-TIG焊焊缝成形的影响

以Ti粉、Si粉和Te粉作为活性剂,研究了单质对低碳钢直流正接A-TIG焊焊缝成形的影响,分析了单质影响熔深的机理.在试验条件下,传统TIG焊的焊缝深宽比为0.24.添加三种活性剂后,焊缝表面都成形良好,Te粉使得焊缝余高增大.Ti粉和Te粉能显著增加熔深,Si粉对焊缝熔深影响则相对较小.Ti和Si粉能使熔宽收缩,而Te粉对熔宽几乎没有影响.在活性剂作用下,Ti粉的焊缝深宽比为0.43;而Te粉的为0.40,Si粉的只有0.35.Si粉、Ti粉、Te粉三者的焊缝熔深排序与其原子半径的大小顺序相同,焊缝熔深变化与单质原子半径大小关系密切.     

Spatial prisoner’s dilemma games with increasing size of the interaction neighborhood on regular lattices

We studied the evolution of cooperation in the prisoner’s dilemma game on a square lattice where the size of the interaction neighborhood is considered. Firstly, the effects of noise and the cost-to-benefit ratio on the maintenance of cooperation were investigated. The results indicate that the cooperation frequency depends on the noise and cost-to-benefit ratio: cooperation reaches a climax as noise increases, but it monotonously decreases and even vanishes with the ratio increasing. Furthermore, we investigated how the size of the interaction neighborhood affects the emergence of cooperation in detail. Our study demonstrates that cooperation is remarkably enhanced by an increase in the size of the interaction neighborhood. However, cooperation died out when the size of the interaction neighborhood became too large since the system was similar to the mean-field system. On this basis, a cluster-forming mechanism acting among cooperators was also explored, and it showed that the moderate range of the neighborhood size is beneficial for forming larger cooperative clusters. Finally, large-scale Monte Carlo simulations were carried out to visualize and interpret these phenomena explicitly.     

Pedigree transmission disequilibrium test for quantitative traits in farm animals

General pedigrees are very common in farm animals,and the recent availability of large panels of SNPs in domestic species has given new momentum to the search for the mutations underlying variation in quantitative traits.In this paper,we proposed a new transmission disequilibrium test approach,called the pedigree transmission disequilibrium test,which deals with general pedigrees and quantitative traits in farm animals.Compared with the existing pedigree disequilibrium test (PDT) and general linear model-based method QTDT,our approach performed better with higher power and lower type I error,especially in scenarios where the quantitative trait locus (QTL) effect was small.We also investigated the application of our approach in selective genotyping design.Our simulation studies indicated that it was plausible to implement a selective genotyping strategy in the proposed pedigree transmission disequilibrium test.We found that our approach performed equally well or better when only some proportion of the individuals in the two tails were genotyped compared with its performance when all the individuals in the pedigree were genotyped.     

Biosorption and biodegradation of polycyclic aromatic hydrocarbons by Phanerochaete chrysosporium in aqueous solution

Biosorption and biodegradation of phenanthrene and pyrene by live and heat-killed Phanerochaete chrysosporium are investigated to elucidate the bio-dissipation mechanisms of polycyclic aromatic hydrocarbons(PAHs) in aqueous solution and its regulating factors.The effects of nutrient conditions(carbon source and nitrogen source concentrations),the co-existing Cu 2+,and repeated-batch feed of PAHs on the biosorption and biodegradation are systematically studied.The removal of PAHs by dead bodies of P.chrysosporium is attributed to biosorption only,and the respective partition coefficients of phenanthrene and pyrene are 4040 and 17500 L/kg.Both biosorption and biodegradation contribute to the dissipation of PAHs by live P.chrysosporium in water.After a 3-d incubation,the removal percentage via biosorption are 19.71% and 52.21% for phenanthrene and pyrene,respectively.With the increase of the incubation time(3 40 d),biodegradation gradually increases from 20.40% to 60.62% for phenanthrene,and from 15.55% to 49.21% for pyrene.Correspondingly,the stored-PAHs in the fungal bodies decrease.Under the carbon-rich and nitrogen-limit nutrient conditions,the removal efficiency and biodegradation of phenanthrene and pyrene are significantly promoted,i.e.99.55% and 92.77% for phenanthrene,and 99.47% and 83.97% for pyrene after a 60-d incubation.This phenomenon is ascribed to enhanced-biosorption due to the increase of fungal biomass under carbon-rich condition,and to stimulated-biodegradation under nitrogen-limit condition.For the repeated-batch feed of phenanthrene,the pollutant is continuously removed by live P.chrysosporium,and the contribution of biodegradation is enhanced with the repeated cycles.After 3 cycles,the biodegradation percentage is up to 90% with each cycle of a 6-d incubation.