排序方式: 共有44条查询结果,搜索用时 0 毫秒
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Dickinson WR 《Nature》1971,232(5305):41-42
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赵照 《国外科技新书评介》2006,(2):19-20
本书是一本传记性著作,记述了20世纪最伟大的科学家之一爱因斯坦的生平。与其他传记体文学不同的是,本书别出心裁的以字母表的顺序,以关键词的方式记录了爱因斯坦的生活、科研、理想等等。从第一个单词大大咧咧的(Absentmindeness),一直到最后一个单词犹太复国主义(Zionism)。每个单词作为一章的标题引出了一段或惊险、或平淡的故事。从本书中读者可以了解爱因斯坦在科学方面的天才想法,可以读到他作为普通人生活的一面——一个可怜的丈夫和父亲,还有他在核武器方面的影响,他创造了相对论却拒绝接受量子力学…… 相似文献
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J R Dorin P Dickinson E W Alton S N Smith D M Geddes B J Stevenson W L Kimber S Fleming A R Clarke M L Hooper 《Nature》1992,359(6392):211-215
Cystic fibrosis is a fatal genetic disorder which afflicts 50,000 people worldwide. A viable animal model would be invaluable for investigating and combating this disease. The mouse cystic fibrosis transmembrane conductance regulator gene was disrupted in embryonal stem cells using an insertional gene targeting vector. Germ-line chimaeras were derived and the offspring of heterozygous crosses studied. These homozygous mutant mice survive beyond weaning. In vivo electrophysiology demonstrates the predicted defect in chloride ion transport in these mice and can distinguish between each genotype. Histological analysis detects important hallmarks of human disease pathology, including abnormalities of the colon, lung and vas deferens. This insertional mouse mutation provides a valid model system for the development and testing of therapies for cystic fibrosis patients. 相似文献
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Kote-Jarai Z Olama AA Giles GG Severi G Schleutker J Weischer M Campa D Riboli E Key T Gronberg H Hunter DJ Kraft P Thun MJ Ingles S Chanock S Albanes D Hayes RB Neal DE Hamdy FC Donovan JL Pharoah P Schumacher F Henderson BE Stanford JL Ostrander EA Sorensen KD Dörk T Andriole G Dickinson JL Cybulski C Lubinski J Spurdle A Clements JA Chambers S Aitken J Gardiner RA Thibodeau SN Schaid D John EM Maier C Vogel W Cooney KA Park JY Cannon-Albright L Brenner H Habuchi T Zhang HW Lu YJ Kaneva R 《Nature genetics》2011,43(8):785-791
Prostate cancer (PrCa) is the most frequently diagnosed male cancer in developed countries. We conducted a multi-stage genome-wide association study for PrCa and previously reported the results of the first two stages, which identified 16 PrCa susceptibility loci. We report here the results of stage 3, in which we evaluated 1,536 SNPs in 4,574 individuals with prostate cancer (cases) and 4,164 controls. We followed up ten new association signals through genotyping in 51,311 samples in 30 studies from the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortium. In addition to replicating previously reported loci, we identified seven new prostate cancer susceptibility loci on chromosomes 2p11, 3q23, 3q26, 5p12, 6p21, 12q13 and Xq12 (P = 4.0 × 10(-8) to P = 2.7 × 10(-24)). We also identified a SNP in TERT more strongly associated with PrCa than that previously reported. More than 40 PrCa susceptibility loci, explaining ~25% of the familial risk in this disease, have now been identified. 相似文献
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Crustacean neuropeptides 总被引:2,自引:0,他引:2
Andrew E. Christie Elizabeth A. Stemmler Patsy S. Dickinson 《Cellular and molecular life sciences : CMLS》2010,67(24):4135-4169
Crustaceans have long been used for peptide research. For example, the process of neurosecretion was first formally demonstrated
in the crustacean X-organ–sinus gland system, and the first fully characterized invertebrate neuropeptide was from a shrimp.
Moreover, the crustacean stomatogastric and cardiac nervous systems have long served as models for understanding the general
principles governing neural circuit functioning, including modulation by peptides. Here, we review the basic biology of crustacean
neuropeptides, discuss methodologies currently driving their discovery, provide an overview of the known families, and summarize
recent data on their control of physiology and behavior. 相似文献
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Abbot P Abe J Alcock J Alizon S Alpedrinha JA Andersson M Andre JB van Baalen M Balloux F Balshine S Barton N Beukeboom LW Biernaskie JM Bilde T Borgia G Breed M Brown S Bshary R Buckling A Burley NT Burton-Chellew MN Cant MA Chapuisat M Charnov EL Clutton-Brock T Cockburn A Cole BJ Colegrave N Cosmides L Couzin ID Coyne JA Creel S Crespi B Curry RL Dall SR Day T Dickinson JL Dugatkin LA El Mouden C Emlen ST Evans J Ferriere R Field J Foitzik S Foster K Foster WA Fox CW Gadau J Gandon S 《Nature》2011,471(7339):E1-4; author reply E9-10
Arising from M. A. Nowak, C. E. Tarnita & E. O. Wilson 466, 1057-1062 (2010); Nowak et al. reply. Nowak et al. argue that inclusive fitness theory has been of little value in explaining the natural world, and that it has led to negligible progress in explaining the evolution of eusociality. However, we believe that their arguments are based upon a misunderstanding of evolutionary theory and a misrepresentation of the empirical literature. We will focus our comments on three general issues. 相似文献
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Pathogenesis of scrapie in the mouse: the role of the spleen 总被引:12,自引:0,他引:12